Ameliorative effects of Artemisia pallens in a murine model of ovalbumin-induced allergic asthma via modulation of biochemical perturbations

•Airway hyperresponsiveness (AHR) was induced in rats by ovalbumin (OVA).•APME significantly attenuated OVA-induced alteration in lung functions.•APME inhibited serum IgE, TNF-α, IL’s, TGF-β levels and decreased lung fibrosis.•APME significantly inhibited oxido-nitrosative stress and increased lung...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2017-10, Vol.94, p.880-889
Hauptverfasser:	Mukherjee, Anwesha A., Kandhare, Amit D., Rojatkar, Supada R., Bodhankar, Subhash L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Airway hyperresponsiveness Animals Anti-Allergic Agents - administration & dosage Anti-Allergic Agents - isolation & purification Anti-Allergic Agents - pharmacology Anti-Asthmatic Agents - administration & dosage Anti-Asthmatic Agents - isolation & purification Anti-Asthmatic Agents - pharmacology Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - isolation & purification Anti-Inflammatory Agents - pharmacology Artemisia - chemistry Artemisia pallens Asthma Asthma - drug therapy Asthma - immunology Bronchoalveolar Lavage Fluid Disease Models, Animal Dose-Response Relationship, Drug Down-Regulation IgE IL’s Male Nrf-2 Ovalbumin Ovalbumin - immunology Plant Extracts - administration & dosage Plant Extracts - pharmacology Rats Rats, Sprague-Dawley Respiratory Function Tests Respiratory Hypersensitivity - drug therapy Respiratory Hypersensitivity - immunology TGF-β TNF-α
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