Ameliorative effects of Artemisia pallens in a murine model of ovalbumin-induced allergic asthma via modulation of biochemical perturbations
•Airway hyperresponsiveness (AHR) was induced in rats by ovalbumin (OVA).•APME significantly attenuated OVA-induced alteration in lung functions.•APME inhibited serum IgE, TNF-α, IL’s, TGF-β levels and decreased lung fibrosis.•APME significantly inhibited oxido-nitrosative stress and increased lung...
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| Veröffentlicht in: | Biomedicine & pharmacotherapy 2017-10, Vol.94, p.880-889 |
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| creator | Mukherjee, Anwesha A. Kandhare, Amit D. Rojatkar, Supada R. Bodhankar, Subhash L. |
| description | •Airway hyperresponsiveness (AHR) was induced in rats by ovalbumin (OVA).•APME significantly attenuated OVA-induced alteration in lung functions.•APME inhibited serum IgE, TNF-α, IL’s, TGF-β levels and decreased lung fibrosis.•APME significantly inhibited oxido-nitrosative stress and increased lung Nrf2 level.•Artemisia pallens exhibits its anti-asthmatic potential in OVA-induced AHR.
Asthma is a chronic, heterogeneous airway disorder characterized by airway inflammatory and remodeling. Artemisia pallens has been reported to possess antioxidant, anti-inflammatory and Anti-allergic potential.
To evaluate the anti-asthmatic effects of methanolic extract of Artemisia pallens (APME) against ovalbumin (OVA)-induced airway hyperresponsiveness (AHR) in rats.
AHR was induced in male Sprague-Dawley rats (180–200g) by intraperitoneal (i.p.) injection of OVA and boosted with an identical OVA solution (s.c.) on day 7. Rats were either treated orally with vehicle (10mg/kg), montelukast (10mg/kg) or APME (100, 200 and 400mg/kg) for next 28days. At the end treatments, various biochemical, molecular (RT-PCR and ELISA analysis) and histological parameters were evaluated.
APME (200 and 400mg/kg) significantly attenuated (p |
| doi_str_mv | 10.1016/j.biopha.2017.08.017 |
| format | Article |
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Asthma is a chronic, heterogeneous airway disorder characterized by airway inflammatory and remodeling. Artemisia pallens has been reported to possess antioxidant, anti-inflammatory and Anti-allergic potential.
To evaluate the anti-asthmatic effects of methanolic extract of Artemisia pallens (APME) against ovalbumin (OVA)-induced airway hyperresponsiveness (AHR) in rats.
AHR was induced in male Sprague-Dawley rats (180–200g) by intraperitoneal (i.p.) injection of OVA and boosted with an identical OVA solution (s.c.) on day 7. Rats were either treated orally with vehicle (10mg/kg), montelukast (10mg/kg) or APME (100, 200 and 400mg/kg) for next 28days. At the end treatments, various biochemical, molecular (RT-PCR and ELISA analysis) and histological parameters were evaluated.
APME (200 and 400mg/kg) significantly attenuated (p<0.05) OVA-induced alteration in lung functions measured by Whole-body plethysmography. Increased Bronchoalveolar Lavage (BAL) fluid differential cell count, as well as total protein and albumin in BAL fluid and lungs, was significantly decreased (p<0.05) by APME. It also significantly attenuated (p<0.05) elevated lung oxido-nitrosative stress, myeloperoxidase, and serum IgE levels. OVA-induced down-regulation in lung Nrf2 and upregulation in TNF-α, IL-1β, IL-4, IL-6, TGF-β mRNA expression was significantly attenuated (p<0.05) by APME (200 and 400mg/kg) treatment. Histopathological analysis of lung tissue showed that APME treatment reduced OVA-induced inflammatory influx and fibrosis.
Artemisia pallens simultaneously orchestrate plethora of mechanisms viz. modulations of IgE, TGF-β, TNF-α, IL’s and Nrf-2 levels to exhibit its anti-asthmatic potential in OVA-induced AHR in rats.</description><identifier>ISSN: 0753-3322</identifier><identifier>EISSN: 1950-6007</identifier><identifier>DOI: 10.1016/j.biopha.2017.08.017</identifier><identifier>PMID: 28810518</identifier><language>eng</language><publisher>France: Elsevier Masson SAS</publisher><subject><![CDATA[Airway hyperresponsiveness ; Animals ; Anti-Allergic Agents - administration & dosage ; Anti-Allergic Agents - isolation & purification ; Anti-Allergic Agents - pharmacology ; Anti-Asthmatic Agents - administration & dosage ; Anti-Asthmatic Agents - isolation & purification ; Anti-Asthmatic Agents - pharmacology ; Anti-Inflammatory Agents - administration & dosage ; Anti-Inflammatory Agents - isolation & purification ; Anti-Inflammatory Agents - pharmacology ; Artemisia - chemistry ; Artemisia pallens ; Asthma ; Asthma - drug therapy ; Asthma - immunology ; Bronchoalveolar Lavage Fluid ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Down-Regulation ; IgE ; IL’s ; Male ; Nrf-2 ; Ovalbumin ; Ovalbumin - immunology ; Plant Extracts - administration & dosage ; Plant Extracts - pharmacology ; Rats ; Rats, Sprague-Dawley ; Respiratory Function Tests ; Respiratory Hypersensitivity - drug therapy ; Respiratory Hypersensitivity - immunology ; TGF-β ; TNF-α]]></subject><ispartof>Biomedicine & pharmacotherapy, 2017-10, Vol.94, p.880-889</ispartof><rights>2017 Elsevier Masson SAS</rights><rights>Copyright © 2017 Elsevier Masson SAS. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c362t-4b667d5dc83c9b77112ab134d4b3f72e69ac00ec4d316b07cc60f298102a60bd3</citedby><cites>FETCH-LOGICAL-c362t-4b667d5dc83c9b77112ab134d4b3f72e69ac00ec4d316b07cc60f298102a60bd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.biopha.2017.08.017$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28810518$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mukherjee, Anwesha A.</creatorcontrib><creatorcontrib>Kandhare, Amit D.</creatorcontrib><creatorcontrib>Rojatkar, Supada R.</creatorcontrib><creatorcontrib>Bodhankar, Subhash L.</creatorcontrib><title>Ameliorative effects of Artemisia pallens in a murine model of ovalbumin-induced allergic asthma via modulation of biochemical perturbations</title><title>Biomedicine & pharmacotherapy</title><addtitle>Biomed Pharmacother</addtitle><description>•Airway hyperresponsiveness (AHR) was induced in rats by ovalbumin (OVA).•APME significantly attenuated OVA-induced alteration in lung functions.•APME inhibited serum IgE, TNF-α, IL’s, TGF-β levels and decreased lung fibrosis.•APME significantly inhibited oxido-nitrosative stress and increased lung Nrf2 level.•Artemisia pallens exhibits its anti-asthmatic potential in OVA-induced AHR.
Asthma is a chronic, heterogeneous airway disorder characterized by airway inflammatory and remodeling. Artemisia pallens has been reported to possess antioxidant, anti-inflammatory and Anti-allergic potential.
To evaluate the anti-asthmatic effects of methanolic extract of Artemisia pallens (APME) against ovalbumin (OVA)-induced airway hyperresponsiveness (AHR) in rats.
AHR was induced in male Sprague-Dawley rats (180–200g) by intraperitoneal (i.p.) injection of OVA and boosted with an identical OVA solution (s.c.) on day 7. Rats were either treated orally with vehicle (10mg/kg), montelukast (10mg/kg) or APME (100, 200 and 400mg/kg) for next 28days. At the end treatments, various biochemical, molecular (RT-PCR and ELISA analysis) and histological parameters were evaluated.
APME (200 and 400mg/kg) significantly attenuated (p<0.05) OVA-induced alteration in lung functions measured by Whole-body plethysmography. Increased Bronchoalveolar Lavage (BAL) fluid differential cell count, as well as total protein and albumin in BAL fluid and lungs, was significantly decreased (p<0.05) by APME. It also significantly attenuated (p<0.05) elevated lung oxido-nitrosative stress, myeloperoxidase, and serum IgE levels. OVA-induced down-regulation in lung Nrf2 and upregulation in TNF-α, IL-1β, IL-4, IL-6, TGF-β mRNA expression was significantly attenuated (p<0.05) by APME (200 and 400mg/kg) treatment. Histopathological analysis of lung tissue showed that APME treatment reduced OVA-induced inflammatory influx and fibrosis.
Artemisia pallens simultaneously orchestrate plethora of mechanisms viz. modulations of IgE, TGF-β, TNF-α, IL’s and Nrf-2 levels to exhibit its anti-asthmatic potential in OVA-induced AHR in rats.</description><subject>Airway hyperresponsiveness</subject><subject>Animals</subject><subject>Anti-Allergic Agents - administration & dosage</subject><subject>Anti-Allergic Agents - isolation & purification</subject><subject>Anti-Allergic Agents - pharmacology</subject><subject>Anti-Asthmatic Agents - administration & dosage</subject><subject>Anti-Asthmatic Agents - isolation & purification</subject><subject>Anti-Asthmatic Agents - pharmacology</subject><subject>Anti-Inflammatory Agents - administration & dosage</subject><subject>Anti-Inflammatory Agents - isolation & purification</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Artemisia - chemistry</subject><subject>Artemisia pallens</subject><subject>Asthma</subject><subject>Asthma - drug therapy</subject><subject>Asthma - immunology</subject><subject>Bronchoalveolar Lavage Fluid</subject><subject>Disease Models, Animal</subject><subject>Dose-Response Relationship, Drug</subject><subject>Down-Regulation</subject><subject>IgE</subject><subject>IL’s</subject><subject>Male</subject><subject>Nrf-2</subject><subject>Ovalbumin</subject><subject>Ovalbumin - immunology</subject><subject>Plant Extracts - administration & dosage</subject><subject>Plant Extracts - pharmacology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Respiratory Function Tests</subject><subject>Respiratory Hypersensitivity - drug therapy</subject><subject>Respiratory Hypersensitivity - immunology</subject><subject>TGF-β</subject><subject>TNF-α</subject><issn>0753-3322</issn><issn>1950-6007</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc2O1DAQhC0EYoeFN0DIRy4JbTtxkgvSaLX8SCtxgbPlnw7jkRMHOxmJd-ChcZiFI6c6-KtuVxchrxnUDJh8d66Nj8tJ1xxYV0NfF3lCDmxooZIA3VNygK4VlRCc35AXOZ8BoJWif05ueN8zaFl_IL-OEwYfk179BSmOI9o10zjSY1px8tlruugQcM7Uz1TTaUt-RjpFh2HH4kUHs01-rvzsNouO7nT67i3VeT1Nml7KiIJvoayI8-4p_7anMtzqQBdM65bMn7f8kjwbdcj46lFvybcP91_vPlUPXz5-vjs-VFZIvlaNkbJzrbO9sIPpOsa4Nkw0rjFi7DjKQVsAtI0TTBrorJUw8qFE5lqCceKWvL3OXVL8sWFeVUlqMQQ9Y9yyYgMfBmBMyoI2V9SmmHPCUS3JTzr9VAzU3oM6q2sPau9BQa-KFNubxw2bmdD9M_09fAHeXwEsOS8ek8rW41wO6FOpQLno_7_hN5Fjnh8</recordid><startdate>201710</startdate><enddate>201710</enddate><creator>Mukherjee, Anwesha A.</creator><creator>Kandhare, Amit D.</creator><creator>Rojatkar, Supada R.</creator><creator>Bodhankar, Subhash L.</creator><general>Elsevier Masson SAS</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201710</creationdate><title>Ameliorative effects of Artemisia pallens in a murine model of ovalbumin-induced allergic asthma via modulation of biochemical perturbations</title><author>Mukherjee, Anwesha A. ; Kandhare, Amit D. ; Rojatkar, Supada R. ; Bodhankar, Subhash L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c362t-4b667d5dc83c9b77112ab134d4b3f72e69ac00ec4d316b07cc60f298102a60bd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Airway hyperresponsiveness</topic><topic>Animals</topic><topic>Anti-Allergic Agents - administration & dosage</topic><topic>Anti-Allergic Agents - isolation & purification</topic><topic>Anti-Allergic Agents - pharmacology</topic><topic>Anti-Asthmatic Agents - administration & dosage</topic><topic>Anti-Asthmatic Agents - isolation & purification</topic><topic>Anti-Asthmatic Agents - pharmacology</topic><topic>Anti-Inflammatory Agents - administration & dosage</topic><topic>Anti-Inflammatory Agents - isolation & purification</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Artemisia - chemistry</topic><topic>Artemisia pallens</topic><topic>Asthma</topic><topic>Asthma - drug therapy</topic><topic>Asthma - immunology</topic><topic>Bronchoalveolar Lavage Fluid</topic><topic>Disease Models, Animal</topic><topic>Dose-Response Relationship, Drug</topic><topic>Down-Regulation</topic><topic>IgE</topic><topic>IL’s</topic><topic>Male</topic><topic>Nrf-2</topic><topic>Ovalbumin</topic><topic>Ovalbumin - immunology</topic><topic>Plant Extracts - administration & dosage</topic><topic>Plant Extracts - pharmacology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Respiratory Function Tests</topic><topic>Respiratory Hypersensitivity - drug therapy</topic><topic>Respiratory Hypersensitivity - immunology</topic><topic>TGF-β</topic><topic>TNF-α</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mukherjee, Anwesha A.</creatorcontrib><creatorcontrib>Kandhare, Amit D.</creatorcontrib><creatorcontrib>Rojatkar, Supada R.</creatorcontrib><creatorcontrib>Bodhankar, Subhash L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biomedicine & pharmacotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mukherjee, Anwesha A.</au><au>Kandhare, Amit D.</au><au>Rojatkar, Supada R.</au><au>Bodhankar, Subhash L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ameliorative effects of Artemisia pallens in a murine model of ovalbumin-induced allergic asthma via modulation of biochemical perturbations</atitle><jtitle>Biomedicine & pharmacotherapy</jtitle><addtitle>Biomed Pharmacother</addtitle><date>2017-10</date><risdate>2017</risdate><volume>94</volume><spage>880</spage><epage>889</epage><pages>880-889</pages><issn>0753-3322</issn><eissn>1950-6007</eissn><abstract>•Airway hyperresponsiveness (AHR) was induced in rats by ovalbumin (OVA).•APME significantly attenuated OVA-induced alteration in lung functions.•APME inhibited serum IgE, TNF-α, IL’s, TGF-β levels and decreased lung fibrosis.•APME significantly inhibited oxido-nitrosative stress and increased lung Nrf2 level.•Artemisia pallens exhibits its anti-asthmatic potential in OVA-induced AHR.
Asthma is a chronic, heterogeneous airway disorder characterized by airway inflammatory and remodeling. Artemisia pallens has been reported to possess antioxidant, anti-inflammatory and Anti-allergic potential.
To evaluate the anti-asthmatic effects of methanolic extract of Artemisia pallens (APME) against ovalbumin (OVA)-induced airway hyperresponsiveness (AHR) in rats.
AHR was induced in male Sprague-Dawley rats (180–200g) by intraperitoneal (i.p.) injection of OVA and boosted with an identical OVA solution (s.c.) on day 7. Rats were either treated orally with vehicle (10mg/kg), montelukast (10mg/kg) or APME (100, 200 and 400mg/kg) for next 28days. At the end treatments, various biochemical, molecular (RT-PCR and ELISA analysis) and histological parameters were evaluated.
APME (200 and 400mg/kg) significantly attenuated (p<0.05) OVA-induced alteration in lung functions measured by Whole-body plethysmography. Increased Bronchoalveolar Lavage (BAL) fluid differential cell count, as well as total protein and albumin in BAL fluid and lungs, was significantly decreased (p<0.05) by APME. It also significantly attenuated (p<0.05) elevated lung oxido-nitrosative stress, myeloperoxidase, and serum IgE levels. OVA-induced down-regulation in lung Nrf2 and upregulation in TNF-α, IL-1β, IL-4, IL-6, TGF-β mRNA expression was significantly attenuated (p<0.05) by APME (200 and 400mg/kg) treatment. Histopathological analysis of lung tissue showed that APME treatment reduced OVA-induced inflammatory influx and fibrosis.
Artemisia pallens simultaneously orchestrate plethora of mechanisms viz. modulations of IgE, TGF-β, TNF-α, IL’s and Nrf-2 levels to exhibit its anti-asthmatic potential in OVA-induced AHR in rats.</abstract><cop>France</cop><pub>Elsevier Masson SAS</pub><pmid>28810518</pmid><doi>10.1016/j.biopha.2017.08.017</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Biomedicine & pharmacotherapy, 2017-10, Vol.94, p.880-889 |
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| subjects | Airway hyperresponsiveness Animals Anti-Allergic Agents - administration & dosage Anti-Allergic Agents - isolation & purification Anti-Allergic Agents - pharmacology Anti-Asthmatic Agents - administration & dosage Anti-Asthmatic Agents - isolation & purification Anti-Asthmatic Agents - pharmacology Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - isolation & purification Anti-Inflammatory Agents - pharmacology Artemisia - chemistry Artemisia pallens Asthma Asthma - drug therapy Asthma - immunology Bronchoalveolar Lavage Fluid Disease Models, Animal Dose-Response Relationship, Drug Down-Regulation IgE IL’s Male Nrf-2 Ovalbumin Ovalbumin - immunology Plant Extracts - administration & dosage Plant Extracts - pharmacology Rats Rats, Sprague-Dawley Respiratory Function Tests Respiratory Hypersensitivity - drug therapy Respiratory Hypersensitivity - immunology TGF-β TNF-α |
| title | Ameliorative effects of Artemisia pallens in a murine model of ovalbumin-induced allergic asthma via modulation of biochemical perturbations |
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