Acute neurotoxic effects of the fungal metabolite ochratoxin-A

Ochratoxin-A (OTA) is a fungal metabolite with potential toxic effects on the central nervous system that have not yet been fully characterized. OTA has complex mechanisms of action that include evocation of oxidative stress, bioenergetic compromise, inhibition of protein synthesis, production of DN...

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Veröffentlicht in:	Neurotoxicology (Park Forest South) 2006, Vol.27 (1), p.82-92
Hauptverfasser:	Sava, V., Reunova, O., Velasquez, A., Harbison, R., Sánchez-Ramos, J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Biological and medical sciences Brain - drug effects Brain - metabolism Caudate Nucleus - drug effects Caudate Nucleus - metabolism Comet Assay DNA Damage DNA Glycosylases - metabolism DNA Repair Dopamine Dopamine - metabolism Dopamine and cAMP-Regulated Phosphoprotein 32 - analysis Dose-Response Relationship, Drug Lipid Peroxidation Male Medical sciences Mice Mice, Inbred ICR Mycotoxins - toxicity Neurons - drug effects Neurons - metabolism Ochratoxin-A Ochratoxins - toxicity Oxidative Stress Oxyguanosine glycosylase Plant poisons toxicology Putamen - drug effects Putamen - metabolism Striatum Substantia nigra Superoxide dismutase Superoxide Dismutase - metabolism Time Factors Toxicology Tyrosine hydroxylase
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