The effect of the fungal metabolite radicicol analog A on mRNA degradation

The AU-rich element (ARE) is a stability determinant found in the 3′ UTR of a number of short-lived mRNAs. The best characterized ARE is the Shaw–Kamen (SK) box or AUUUA motif. Previously, a fungal metabolite, radicicol analog A (RAA), was shown to destabilize SK box-containing mRNAs based on 16 mRN...

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Veröffentlicht in:	Genomics (San Diego, Calif.) Calif.), 2007-12, Vol.90 (6), p.723-732
Hauptverfasser:	Mak, Isabella W.Y., Liu, Lin, Ling, Victor, Kastelic, Tania
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions AU-rich element Base Sequence Biological and medical sciences Cell Line DNA Primers - genetics Down-Regulation - drug effects Fundamental and applied biological sciences. Psychology Fungi - metabolism Gene Expression - drug effects Gene expression profiling Genes. Genome Genetics of eukaryotes. Biological and molecular evolution Human Humans Interferon-gamma - pharmacology Lipopolysaccharides - pharmacology Macrolides - chemistry Macrolides - metabolism Macrolides - pharmacology Molecular and cellular biology Molecular genetics Monocyte/macrophage Monocytes - drug effects Monocytes - metabolism mRNA stability Radicicol analog Reverse Transcriptase Polymerase Chain Reaction RNA Stability - drug effects RNA, Messenger - genetics RNA, Messenger - metabolism SAGE SK box THP-1 cells
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