Temporal Relationship Between Hyperuricemia and Insulin Resistance and Its Impact on Future Risk of Hypertension
Although hyperuricemia and insulin resistance significantly correlated, their temporal sequence and how the sequence influence on future risk of hypertension are largely unknown. This study assessed temporal relationship between uric acid and insulin resistance and its impact on future risk of hyper...
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| Veröffentlicht in: | Hypertension (Dallas, Tex. 1979) Tex. 1979), 2017-10, Vol.70 (4), p.703-711 |
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| creator | Han, Tianshu Lan, Li Qu, Rongge Xu, Qian Jiang, Ruyue Na, Lixin Sun, Changhao |
| description | Although hyperuricemia and insulin resistance significantly correlated, their temporal sequence and how the sequence influence on future risk of hypertension are largely unknown. This study assessed temporal relationship between uric acid and insulin resistance and its impact on future risk of hypertension by examining a longitudinal cohort including 8543 subjects aged 20 to 74 years from China, with an average follow-up of 5.3 years. Measurements of fasting uric acid, as well as fasting and 2-hour serum glucose and insulin, were obtained at baseline and follow-up. Indicators of hepatic and peripheral insulin resistance were calculated. Cross-lagged panel and mediation analysis were used to examine the temporal relationship between uric acid and insulin resistance and its impact on follow-up hypertension. After adjusting for covariates, the cross-lagged path coefficients (β1 values) from baseline uric acid to follow-up insulin resistance indices were significantly greater than path coefficients (β2 values) from baseline insulin resistance indices to follow-up uric acid (β1=0.110 versus β2=0.017; P |
| doi_str_mv | 10.1161/HYPERTENSIONAHA.117.09508 |
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This study assessed temporal relationship between uric acid and insulin resistance and its impact on future risk of hypertension by examining a longitudinal cohort including 8543 subjects aged 20 to 74 years from China, with an average follow-up of 5.3 years. Measurements of fasting uric acid, as well as fasting and 2-hour serum glucose and insulin, were obtained at baseline and follow-up. Indicators of hepatic and peripheral insulin resistance were calculated. Cross-lagged panel and mediation analysis were used to examine the temporal relationship between uric acid and insulin resistance and its impact on follow-up hypertension. After adjusting for covariates, the cross-lagged path coefficients (β1 values) from baseline uric acid to follow-up insulin resistance indices were significantly greater than path coefficients (β2 values) from baseline insulin resistance indices to follow-up uric acid (β1=0.110 versus β2=0.017; P<0.001, for hepatic insulin resistance; β1=−0.208 versus β2=−0.021; P<0.001, for peripheral insulin resistance). The path coefficients from baseline uric acid to follow-up insulin resistance indices in the hypertensive group were significantly greater than that in the normotensive group (P<0.001 for the difference of β1 values in the 2 groups). Insulin resistance partially mediated the effect of uric acid on subsequent hypertension, and the mediation effect of peripheral insulin resistance was significantly greater than that of hepatic insulin resistance (31.3% versus 13.2%; P<0.001, for the difference of mediation effects). These findings provide evidence that higher uric acid levels probably precede insulin resistance, and peripheral insulin resistance likely plays a more important role in the development of hypertension than hepatic insulin resistance does.</description><identifier>ISSN: 0194-911X</identifier><identifier>EISSN: 1524-4563</identifier><identifier>DOI: 10.1161/HYPERTENSIONAHA.117.09508</identifier><identifier>PMID: 28808071</identifier><language>eng</language><publisher>United States: American Heart Association, Inc</publisher><subject>Adult ; Aged ; Blood Glucose - analysis ; Blood Pressure Determination - methods ; Blood Pressure Determination - statistics & numerical data ; China - epidemiology ; Cohort Studies ; Female ; Humans ; Hypertension - diagnosis ; Hypertension - epidemiology ; Hyperuricemia - diagnosis ; Hyperuricemia - epidemiology ; Insulin Resistance - physiology ; Longitudinal Studies ; Male ; Middle Aged ; Risk Factors ; Time Factors ; Uric Acid - blood</subject><ispartof>Hypertension (Dallas, Tex. 1979), 2017-10, Vol.70 (4), p.703-711</ispartof><rights>2017 American Heart Association, Inc</rights><rights>2017 American Heart Association, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4228-9486271bbd834c0b5be21c4f00e0aadf32fd33a3349878184735b8e0ce6018c53</citedby><cites>FETCH-LOGICAL-c4228-9486271bbd834c0b5be21c4f00e0aadf32fd33a3349878184735b8e0ce6018c53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3674,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28808071$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Han, Tianshu</creatorcontrib><creatorcontrib>Lan, Li</creatorcontrib><creatorcontrib>Qu, Rongge</creatorcontrib><creatorcontrib>Xu, Qian</creatorcontrib><creatorcontrib>Jiang, Ruyue</creatorcontrib><creatorcontrib>Na, Lixin</creatorcontrib><creatorcontrib>Sun, Changhao</creatorcontrib><title>Temporal Relationship Between Hyperuricemia and Insulin Resistance and Its Impact on Future Risk of Hypertension</title><title>Hypertension (Dallas, Tex. 1979)</title><addtitle>Hypertension</addtitle><description>Although hyperuricemia and insulin resistance significantly correlated, their temporal sequence and how the sequence influence on future risk of hypertension are largely unknown. This study assessed temporal relationship between uric acid and insulin resistance and its impact on future risk of hypertension by examining a longitudinal cohort including 8543 subjects aged 20 to 74 years from China, with an average follow-up of 5.3 years. Measurements of fasting uric acid, as well as fasting and 2-hour serum glucose and insulin, were obtained at baseline and follow-up. Indicators of hepatic and peripheral insulin resistance were calculated. Cross-lagged panel and mediation analysis were used to examine the temporal relationship between uric acid and insulin resistance and its impact on follow-up hypertension. After adjusting for covariates, the cross-lagged path coefficients (β1 values) from baseline uric acid to follow-up insulin resistance indices were significantly greater than path coefficients (β2 values) from baseline insulin resistance indices to follow-up uric acid (β1=0.110 versus β2=0.017; P<0.001, for hepatic insulin resistance; β1=−0.208 versus β2=−0.021; P<0.001, for peripheral insulin resistance). The path coefficients from baseline uric acid to follow-up insulin resistance indices in the hypertensive group were significantly greater than that in the normotensive group (P<0.001 for the difference of β1 values in the 2 groups). Insulin resistance partially mediated the effect of uric acid on subsequent hypertension, and the mediation effect of peripheral insulin resistance was significantly greater than that of hepatic insulin resistance (31.3% versus 13.2%; P<0.001, for the difference of mediation effects). These findings provide evidence that higher uric acid levels probably precede insulin resistance, and peripheral insulin resistance likely plays a more important role in the development of hypertension than hepatic insulin resistance does.</description><subject>Adult</subject><subject>Aged</subject><subject>Blood Glucose - analysis</subject><subject>Blood Pressure Determination - methods</subject><subject>Blood Pressure Determination - statistics & numerical data</subject><subject>China - epidemiology</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Hypertension - diagnosis</subject><subject>Hypertension - epidemiology</subject><subject>Hyperuricemia - diagnosis</subject><subject>Hyperuricemia - epidemiology</subject><subject>Insulin Resistance - physiology</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Risk Factors</subject><subject>Time Factors</subject><subject>Uric Acid - blood</subject><issn>0194-911X</issn><issn>1524-4563</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMFO3DAURa2Kqgy0v1CZHZuAX-wkzqKLAQ2dkRBU06nUriLHedG4OE6wHY34-wYCXXTV1ZOuzr1POoScAbsAyOFy_evbartb3X3f3N8t18spLC5YmTH5jiwgS0UispwfkQWDUiQlwM9jchLCb8ZACFF8IMeplEyyAhZk2GE39F5ZukWrould2JuBXmE8IDq6fhrQj95o7IyiyjV048JojZvwYEJUTuMcx0A33aB0pL2jN2McPdKtCQ-0b-eViC5M8x_J-1bZgJ9e7yn5cbPaXa-T2_uvm-vlbaJFmsqkFDJPC6jrRnKhWZ3VmIIWLWPIlGpanrYN54pzUcpCghQFz2qJTGPOQOqMn5LzeXfw_eOIIVadCRqtVQ77MVRQpiWwjOfPaDmj2vcheGyrwZtO-acKWPUsvPpH-BQW1Yvwqfv59c1Yd9j8bb4ZnoAvM3DobUQfHux4QF_tUdm4_48HfwA_vpLK</recordid><startdate>201710</startdate><enddate>201710</enddate><creator>Han, Tianshu</creator><creator>Lan, Li</creator><creator>Qu, Rongge</creator><creator>Xu, Qian</creator><creator>Jiang, Ruyue</creator><creator>Na, Lixin</creator><creator>Sun, Changhao</creator><general>American Heart Association, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201710</creationdate><title>Temporal Relationship Between Hyperuricemia and Insulin Resistance and Its Impact on Future Risk of Hypertension</title><author>Han, Tianshu ; Lan, Li ; Qu, Rongge ; Xu, Qian ; Jiang, Ruyue ; Na, Lixin ; Sun, Changhao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4228-9486271bbd834c0b5be21c4f00e0aadf32fd33a3349878184735b8e0ce6018c53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Blood Glucose - analysis</topic><topic>Blood Pressure Determination - methods</topic><topic>Blood Pressure Determination - statistics & numerical data</topic><topic>China - epidemiology</topic><topic>Cohort Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Hypertension - diagnosis</topic><topic>Hypertension - epidemiology</topic><topic>Hyperuricemia - diagnosis</topic><topic>Hyperuricemia - epidemiology</topic><topic>Insulin Resistance - physiology</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Risk Factors</topic><topic>Time Factors</topic><topic>Uric Acid - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Han, Tianshu</creatorcontrib><creatorcontrib>Lan, Li</creatorcontrib><creatorcontrib>Qu, Rongge</creatorcontrib><creatorcontrib>Xu, Qian</creatorcontrib><creatorcontrib>Jiang, Ruyue</creatorcontrib><creatorcontrib>Na, Lixin</creatorcontrib><creatorcontrib>Sun, Changhao</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Han, Tianshu</au><au>Lan, Li</au><au>Qu, Rongge</au><au>Xu, Qian</au><au>Jiang, Ruyue</au><au>Na, Lixin</au><au>Sun, Changhao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Temporal Relationship Between Hyperuricemia and Insulin Resistance and Its Impact on Future Risk of Hypertension</atitle><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle><addtitle>Hypertension</addtitle><date>2017-10</date><risdate>2017</risdate><volume>70</volume><issue>4</issue><spage>703</spage><epage>711</epage><pages>703-711</pages><issn>0194-911X</issn><eissn>1524-4563</eissn><abstract>Although hyperuricemia and insulin resistance significantly correlated, their temporal sequence and how the sequence influence on future risk of hypertension are largely unknown. This study assessed temporal relationship between uric acid and insulin resistance and its impact on future risk of hypertension by examining a longitudinal cohort including 8543 subjects aged 20 to 74 years from China, with an average follow-up of 5.3 years. Measurements of fasting uric acid, as well as fasting and 2-hour serum glucose and insulin, were obtained at baseline and follow-up. Indicators of hepatic and peripheral insulin resistance were calculated. Cross-lagged panel and mediation analysis were used to examine the temporal relationship between uric acid and insulin resistance and its impact on follow-up hypertension. After adjusting for covariates, the cross-lagged path coefficients (β1 values) from baseline uric acid to follow-up insulin resistance indices were significantly greater than path coefficients (β2 values) from baseline insulin resistance indices to follow-up uric acid (β1=0.110 versus β2=0.017; P<0.001, for hepatic insulin resistance; β1=−0.208 versus β2=−0.021; P<0.001, for peripheral insulin resistance). The path coefficients from baseline uric acid to follow-up insulin resistance indices in the hypertensive group were significantly greater than that in the normotensive group (P<0.001 for the difference of β1 values in the 2 groups). Insulin resistance partially mediated the effect of uric acid on subsequent hypertension, and the mediation effect of peripheral insulin resistance was significantly greater than that of hepatic insulin resistance (31.3% versus 13.2%; P<0.001, for the difference of mediation effects). These findings provide evidence that higher uric acid levels probably precede insulin resistance, and peripheral insulin resistance likely plays a more important role in the development of hypertension than hepatic insulin resistance does.</abstract><cop>United States</cop><pub>American Heart Association, Inc</pub><pmid>28808071</pmid><doi>10.1161/HYPERTENSIONAHA.117.09508</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Blood Glucose - analysis Blood Pressure Determination - methods Blood Pressure Determination - statistics & numerical data China - epidemiology Cohort Studies Female Humans Hypertension - diagnosis Hypertension - epidemiology Hyperuricemia - diagnosis Hyperuricemia - epidemiology Insulin Resistance - physiology Longitudinal Studies Male Middle Aged Risk Factors Time Factors Uric Acid - blood |
| title | Temporal Relationship Between Hyperuricemia and Insulin Resistance and Its Impact on Future Risk of Hypertension |
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