Axially substituted silicon(IV) phthalocyanine and its quaternized derivative as photosensitizers towards tumor cells and bacterial pathogens

[Display omitted] Axially di-(alpha,alpha-diphenyl-4-pyridylmethoxy) silicon(IV) phthalocyanine (3) and its quaternized derivative (3Q) were synthesized and tested as photosensitizers against tumor and bacterial cells. These new phthalocyanines were characterized by elemental analysis, and different...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2017-10, Vol.25 (20), p.5415-5422
Hauptverfasser:	Ömeroğlu, İpek, Kaya, Esra Nur, Göksel, Meltem, Kussovski, Vesselin, Mantareva, Vanya, Durmuş, Mahmut
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Cell Proliferation - drug effects Dose-Response Relationship, Drug Drug Screening Assays, Antitumor HeLa Cells HeLa tumor cells Humans Indoles - chemistry Indoles - pharmacology Microbial Sensitivity Tests Molecular Structure Organosilicon Compounds - chemistry Organosilicon Compounds - pharmacology Pathogenic bacteria Photodynamic therapy Photophysicochemical properties Photosensitizing Agents - chemical synthesis Photosensitizing Agents - chemistry Photosensitizing Agents - pharmacology Pseudomonas aeruginosa - drug effects Silicon phthalocyanine Staphylococcus aureus - drug effects Streptococcus mutans - drug effects Structure-Activity Relationship
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