Isolation and identification of pectenotoxins-13 and -14 from Dinophysis acuta in New Zealand
Two novel pectenotoxins (PTXs), PTX-13 and -14, were isolated from extracts of Dinophysis acuta collected from the west coast of South Island, New Zealand. The compounds were identified as oxidized analogues of PTX-2 by NMR spectroscopic and LC-MS studies. PTX-13 (32 R-hydroxyPTX-2) corresponds to t...
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| Veröffentlicht in: | Toxicon (Oxford) 2006-08, Vol.48 (2), p.152-159 |
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| creator | Miles, Christopher Owen Wilkins, Alistair L. Hawkes, Allan D. Jensen, Dwayne J. Selwood, Andrew I. Beuzenberg, Veronica Lincoln MacKenzie, A. Cooney, Janine M. Holland, Patrick T. |
| description | Two novel pectenotoxins (PTXs), PTX-13 and -14, were isolated from extracts of
Dinophysis acuta collected from the west coast of South Island, New Zealand. The compounds were identified as oxidized analogues of PTX-2 by NMR spectroscopic and LC-MS studies. PTX-13 (32
R-hydroxyPTX-2) corresponds to the unidentified analogue PTX-11x reported by [Suzuki et al., 2003. Liquid chromatography-mass spectrometry of spiroketal stereoisomers of pectenotoxins and the analysis of novel pectenotoxin isomers in the toxic dinoflagellate
Dinophysis acuta from New Zealand. J. Chromatogr. A 992, 141–150]. PTX-13 underwent slow deuteration at the 13β-position during NMR analysis. PTX-14 corresponds to the 32,36-dehydration product of PTX-13, and may be an artifact. |
| doi_str_mv | 10.1016/j.toxicon.2006.04.005 |
| format | Article |
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Dinophysis acuta collected from the west coast of South Island, New Zealand. The compounds were identified as oxidized analogues of PTX-2 by NMR spectroscopic and LC-MS studies. PTX-13 (32
R-hydroxyPTX-2) corresponds to the unidentified analogue PTX-11x reported by [Suzuki et al., 2003. Liquid chromatography-mass spectrometry of spiroketal stereoisomers of pectenotoxins and the analysis of novel pectenotoxin isomers in the toxic dinoflagellate
Dinophysis acuta from New Zealand. J. Chromatogr. A 992, 141–150]. PTX-13 underwent slow deuteration at the 13β-position during NMR analysis. PTX-14 corresponds to the 32,36-dehydration product of PTX-13, and may be an artifact.</description><identifier>ISSN: 0041-0101</identifier><identifier>EISSN: 1879-3150</identifier><identifier>DOI: 10.1016/j.toxicon.2006.04.005</identifier><identifier>PMID: 16828828</identifier><identifier>CODEN: TOXIA6</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Animals ; Biological and medical sciences ; Chromatography, High Pressure Liquid ; Dinoflagellida - chemistry ; Dinoflagellida - metabolism ; Dinophysis acuta ; Furans - chemistry ; Furans - isolation & purification ; LC-MS ; Marine Toxins - chemistry ; Marine Toxins - isolation & purification ; Medical sciences ; Molecular Structure ; New Zealand ; NMR ; Pectenotoxins ; Plant poisons toxicology ; Pyrans - chemistry ; Pyrans - isolation & purification ; Spectrometry, Mass, Electrospray Ionization ; Toxicology</subject><ispartof>Toxicon (Oxford), 2006-08, Vol.48 (2), p.152-159</ispartof><rights>2006 Elsevier Ltd</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c490t-34bd8109db5116bf1ee14786492f6c3aa10389899d1b203df53be47ca6cacf8d3</citedby><cites>FETCH-LOGICAL-c490t-34bd8109db5116bf1ee14786492f6c3aa10389899d1b203df53be47ca6cacf8d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0041010106001346$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18013764$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16828828$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Miles, Christopher Owen</creatorcontrib><creatorcontrib>Wilkins, Alistair L.</creatorcontrib><creatorcontrib>Hawkes, Allan D.</creatorcontrib><creatorcontrib>Jensen, Dwayne J.</creatorcontrib><creatorcontrib>Selwood, Andrew I.</creatorcontrib><creatorcontrib>Beuzenberg, Veronica</creatorcontrib><creatorcontrib>Lincoln MacKenzie, A.</creatorcontrib><creatorcontrib>Cooney, Janine M.</creatorcontrib><creatorcontrib>Holland, Patrick T.</creatorcontrib><title>Isolation and identification of pectenotoxins-13 and -14 from Dinophysis acuta in New Zealand</title><title>Toxicon (Oxford)</title><addtitle>Toxicon</addtitle><description>Two novel pectenotoxins (PTXs), PTX-13 and -14, were isolated from extracts of
Dinophysis acuta collected from the west coast of South Island, New Zealand. The compounds were identified as oxidized analogues of PTX-2 by NMR spectroscopic and LC-MS studies. PTX-13 (32
R-hydroxyPTX-2) corresponds to the unidentified analogue PTX-11x reported by [Suzuki et al., 2003. Liquid chromatography-mass spectrometry of spiroketal stereoisomers of pectenotoxins and the analysis of novel pectenotoxin isomers in the toxic dinoflagellate
Dinophysis acuta from New Zealand. J. Chromatogr. A 992, 141–150]. PTX-13 underwent slow deuteration at the 13β-position during NMR analysis. PTX-14 corresponds to the 32,36-dehydration product of PTX-13, and may be an artifact.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Dinoflagellida - chemistry</subject><subject>Dinoflagellida - metabolism</subject><subject>Dinophysis acuta</subject><subject>Furans - chemistry</subject><subject>Furans - isolation & purification</subject><subject>LC-MS</subject><subject>Marine Toxins - chemistry</subject><subject>Marine Toxins - isolation & purification</subject><subject>Medical sciences</subject><subject>Molecular Structure</subject><subject>New Zealand</subject><subject>NMR</subject><subject>Pectenotoxins</subject><subject>Plant poisons toxicology</subject><subject>Pyrans - chemistry</subject><subject>Pyrans - isolation & purification</subject><subject>Spectrometry, Mass, Electrospray Ionization</subject><subject>Toxicology</subject><issn>0041-0101</issn><issn>1879-3150</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE2LFDEQhoO4uOPqT1By0Vv3VnXS6fRJZNePhUUvehEkpPOBGXqSMenZdf-9Gadhj0KgIDxV9dZDyCuEFgHF5bZd0p9gUmw7ANECbwH6J2SDchgbhj08JRsAjg1U_Jw8L2ULAEyO4hk5RyE7Wd-G_LwpadZLSJHqaGmwLi7BB3P6Sp7unVlcTMdlsTTI_mENcupz2tHrENP-10MJhWpzWDQNkX5x9_SH03MFX5Azr-fiXq71gnz_-OHb1efm9uunm6v3t43hIywN45OVCKOdekQxeXQO-SAFHzsvDNMaj8HlOFqcOmDW92xyfDBaGG28tOyCvD3N3ef0--DKonahGDfXDC4disKxq4cPUMH-BJqcSsnOq30OO50fFII6elVbtXpVR68KuKpea9_rdcFh2jn72LWKrMCbFdDF6NlnHU0oj5wEZIPglXt34lzVcRdcVsUEF42zIVfTyqbwnyh_Ae8TmO4</recordid><startdate>20060801</startdate><enddate>20060801</enddate><creator>Miles, Christopher Owen</creator><creator>Wilkins, Alistair L.</creator><creator>Hawkes, Allan D.</creator><creator>Jensen, Dwayne J.</creator><creator>Selwood, Andrew I.</creator><creator>Beuzenberg, Veronica</creator><creator>Lincoln MacKenzie, A.</creator><creator>Cooney, Janine M.</creator><creator>Holland, Patrick T.</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope><scope>M7N</scope></search><sort><creationdate>20060801</creationdate><title>Isolation and identification of pectenotoxins-13 and -14 from Dinophysis acuta in New Zealand</title><author>Miles, Christopher Owen ; 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| subjects | Animals Biological and medical sciences Chromatography, High Pressure Liquid Dinoflagellida - chemistry Dinoflagellida - metabolism Dinophysis acuta Furans - chemistry Furans - isolation & purification LC-MS Marine Toxins - chemistry Marine Toxins - isolation & purification Medical sciences Molecular Structure New Zealand NMR Pectenotoxins Plant poisons toxicology Pyrans - chemistry Pyrans - isolation & purification Spectrometry, Mass, Electrospray Ionization Toxicology |
| title | Isolation and identification of pectenotoxins-13 and -14 from Dinophysis acuta in New Zealand |
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