Reproductive effects and bioconcentration of 4-nonylphenol in medaka fish ( Oryzias latipes)
The objective of this study was to investigate the reproductive success (fertility and fecundity) of medaka ( Oryzias latipes) exposed to 4-nonylphenol (4-NP) in water and the viability of their F 1 offspring. In addition, we measured the bioconcentration of 4-NP in eggs. After a 21-d exposure to 10...
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| Veröffentlicht in: | Chemosphere (Oxford) 2006-11, Vol.65 (6), p.1019-1026 |
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| creator | Ishibashi, Hiroshi Hirano, Masashi Matsumura, Naomi Watanabe, Naoko Takao, Yuji Arizono, Koji |
| description | The objective of this study was to investigate the reproductive success (fertility and fecundity) of medaka (
Oryzias latipes) exposed to 4-nonylphenol (4-NP) in water and the viability of their F
1 offspring. In addition, we measured the bioconcentration of 4-NP in eggs. After a 21-d exposure to 100
μg/l 4-NP, medaka showed reduced egg production and fertility. Hepatic vitellogenin levels were increased significantly in males treated with 10, 50 and 100
μg/l of 4-NP. In the F
1 generations, the hatchability and time to hatching of embryos in the 100
μg/l treatment group were adversely affected, and 2–7
μg 4-NP/g egg was found in spawned eggs (the bioconcentration factor: 30–100). These results indicate that (1) 4-NP adversely affected the reproduction (fecundity and fertility) of adult medaka, (2) 4-NP accumulated in eggs through maternal transfer and (3) these levels of 4-NP were associated with adverse effects in the F
1 offspring. |
| doi_str_mv | 10.1016/j.chemosphere.2006.03.034 |
| format | Article |
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Oryzias latipes) exposed to 4-nonylphenol (4-NP) in water and the viability of their F
1 offspring. In addition, we measured the bioconcentration of 4-NP in eggs. After a 21-d exposure to 100
μg/l 4-NP, medaka showed reduced egg production and fertility. Hepatic vitellogenin levels were increased significantly in males treated with 10, 50 and 100
μg/l of 4-NP. In the F
1 generations, the hatchability and time to hatching of embryos in the 100
μg/l treatment group were adversely affected, and 2–7
μg 4-NP/g egg was found in spawned eggs (the bioconcentration factor: 30–100). These results indicate that (1) 4-NP adversely affected the reproduction (fecundity and fertility) of adult medaka, (2) 4-NP accumulated in eggs through maternal transfer and (3) these levels of 4-NP were associated with adverse effects in the F
1 offspring.</description><identifier>ISSN: 0045-6535</identifier><identifier>EISSN: 1879-1298</identifier><identifier>DOI: 10.1016/j.chemosphere.2006.03.034</identifier><identifier>PMID: 16677682</identifier><identifier>CODEN: CMSHAF</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Agnatha. Pisces ; Animal, plant and microbial ecology ; Animals ; Applied ecology ; Bioconcentration ; Biological and medical sciences ; Dose-Response Relationship, Drug ; Ecotoxicology, biological effects of pollution ; Embryo, Nonmammalian - drug effects ; Embryo, Nonmammalian - physiology ; Female ; Freshwater ; Fundamental and applied biological sciences. Psychology ; General aspects ; Liver - drug effects ; Liver - metabolism ; Male ; Maternal transfer ; Medaka ; Nonylphenol ; Oryzias - physiology ; Oryzias latipes ; Ovum - drug effects ; Ovum - growth & development ; Phenols - toxicity ; Reproduction ; Reproduction - drug effects ; Reproduction - physiology ; Time Factors ; Toxicity Tests ; Vertebrates: general zoology, morphology, phylogeny, systematics, cytogenetics, geographical distribution ; Vitellogenins - analysis ; Vitellogenins - metabolism ; Water Pollutants, Chemical - toxicity</subject><ispartof>Chemosphere (Oxford), 2006-11, Vol.65 (6), p.1019-1026</ispartof><rights>2006 Elsevier Ltd</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c533t-b8d9c138267f94112fe070d74162ecba7035382d86dc5879cc1063e5e63d450e3</citedby><cites>FETCH-LOGICAL-c533t-b8d9c138267f94112fe070d74162ecba7035382d86dc5879cc1063e5e63d450e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.chemosphere.2006.03.034$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18248340$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16677682$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ishibashi, Hiroshi</creatorcontrib><creatorcontrib>Hirano, Masashi</creatorcontrib><creatorcontrib>Matsumura, Naomi</creatorcontrib><creatorcontrib>Watanabe, Naoko</creatorcontrib><creatorcontrib>Takao, Yuji</creatorcontrib><creatorcontrib>Arizono, Koji</creatorcontrib><title>Reproductive effects and bioconcentration of 4-nonylphenol in medaka fish ( Oryzias latipes)</title><title>Chemosphere (Oxford)</title><addtitle>Chemosphere</addtitle><description>The objective of this study was to investigate the reproductive success (fertility and fecundity) of medaka (
Oryzias latipes) exposed to 4-nonylphenol (4-NP) in water and the viability of their F
1 offspring. In addition, we measured the bioconcentration of 4-NP in eggs. After a 21-d exposure to 100
μg/l 4-NP, medaka showed reduced egg production and fertility. Hepatic vitellogenin levels were increased significantly in males treated with 10, 50 and 100
μg/l of 4-NP. In the F
1 generations, the hatchability and time to hatching of embryos in the 100
μg/l treatment group were adversely affected, and 2–7
μg 4-NP/g egg was found in spawned eggs (the bioconcentration factor: 30–100). These results indicate that (1) 4-NP adversely affected the reproduction (fecundity and fertility) of adult medaka, (2) 4-NP accumulated in eggs through maternal transfer and (3) these levels of 4-NP were associated with adverse effects in the F
1 offspring.</description><subject>Agnatha. Pisces</subject><subject>Animal, plant and microbial ecology</subject><subject>Animals</subject><subject>Applied ecology</subject><subject>Bioconcentration</subject><subject>Biological and medical sciences</subject><subject>Dose-Response Relationship, Drug</subject><subject>Ecotoxicology, biological effects of pollution</subject><subject>Embryo, Nonmammalian - drug effects</subject><subject>Embryo, Nonmammalian - physiology</subject><subject>Female</subject><subject>Freshwater</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General aspects</subject><subject>Liver - drug effects</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>Maternal transfer</subject><subject>Medaka</subject><subject>Nonylphenol</subject><subject>Oryzias - physiology</subject><subject>Oryzias latipes</subject><subject>Ovum - drug effects</subject><subject>Ovum - growth & development</subject><subject>Phenols - toxicity</subject><subject>Reproduction</subject><subject>Reproduction - drug effects</subject><subject>Reproduction - physiology</subject><subject>Time Factors</subject><subject>Toxicity Tests</subject><subject>Vertebrates: general zoology, morphology, phylogeny, systematics, cytogenetics, geographical distribution</subject><subject>Vitellogenins - analysis</subject><subject>Vitellogenins - metabolism</subject><subject>Water Pollutants, Chemical - toxicity</subject><issn>0045-6535</issn><issn>1879-1298</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkV2LUzEQhoMobl39CxIvFL04Nd8nuVyKX7CwIHonhDSZ0NTTpCanC_XXm9LCeqcwkIt53pnM-yL0ipIlJVS93y79Bnal7TdQYckIUUvCe4lHaEH1aAbKjH6MFoQIOSjJ5RV61tqWkC6W5im6okqNo9JsgX58hX0t4eDndA8YYgQ_N-xywOtUfMke8lzdnErGJWIx5JKPU9-by4RTxjsI7qfDMbUNfovv6vF3cg1PXbCH9u45ehLd1ODF5b1G3z9--Lb6PNzeffqyurkdvOR8HtY6GE-5ZmqMRlDKIpCRhFFQxcCv3Ui47N2gVfCyn-c9JYqDBMWDkAT4NXpznttP-XWANttdah6myWUoh2apYdpIRv8NCk2oEaKD5gz6WlqrEO2-pp2rR0uJPWVgt_avDOwpA0t4r5P25WXJYd39eVBeTO_A6wvgmndTrC771B44zYTmgnRudeage3efoNrmE_RIQqo9JhtK-o_v_AGWnaqw</recordid><startdate>20061101</startdate><enddate>20061101</enddate><creator>Ishibashi, Hiroshi</creator><creator>Hirano, Masashi</creator><creator>Matsumura, Naomi</creator><creator>Watanabe, Naoko</creator><creator>Takao, Yuji</creator><creator>Arizono, Koji</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>C1K</scope><scope>SOI</scope><scope>7QH</scope><scope>7TV</scope><scope>7U7</scope><scope>7UA</scope><scope>F1W</scope><scope>H97</scope><scope>L.G</scope></search><sort><creationdate>20061101</creationdate><title>Reproductive effects and bioconcentration of 4-nonylphenol in medaka fish ( Oryzias latipes)</title><author>Ishibashi, Hiroshi ; Hirano, Masashi ; Matsumura, Naomi ; Watanabe, Naoko ; Takao, Yuji ; Arizono, Koji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c533t-b8d9c138267f94112fe070d74162ecba7035382d86dc5879cc1063e5e63d450e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Agnatha. Pisces</topic><topic>Animal, plant and microbial ecology</topic><topic>Animals</topic><topic>Applied ecology</topic><topic>Bioconcentration</topic><topic>Biological and medical sciences</topic><topic>Dose-Response Relationship, Drug</topic><topic>Ecotoxicology, biological effects of pollution</topic><topic>Embryo, Nonmammalian - drug effects</topic><topic>Embryo, Nonmammalian - physiology</topic><topic>Female</topic><topic>Freshwater</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General aspects</topic><topic>Liver - drug effects</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>Maternal transfer</topic><topic>Medaka</topic><topic>Nonylphenol</topic><topic>Oryzias - physiology</topic><topic>Oryzias latipes</topic><topic>Ovum - drug effects</topic><topic>Ovum - growth & development</topic><topic>Phenols - toxicity</topic><topic>Reproduction</topic><topic>Reproduction - drug effects</topic><topic>Reproduction - physiology</topic><topic>Time Factors</topic><topic>Toxicity Tests</topic><topic>Vertebrates: general zoology, morphology, phylogeny, systematics, cytogenetics, geographical distribution</topic><topic>Vitellogenins - analysis</topic><topic>Vitellogenins - metabolism</topic><topic>Water Pollutants, Chemical - toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ishibashi, Hiroshi</creatorcontrib><creatorcontrib>Hirano, Masashi</creatorcontrib><creatorcontrib>Matsumura, Naomi</creatorcontrib><creatorcontrib>Watanabe, Naoko</creatorcontrib><creatorcontrib>Takao, Yuji</creatorcontrib><creatorcontrib>Arizono, Koji</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><collection>Aqualine</collection><collection>Pollution Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Water Resources Abstracts</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><jtitle>Chemosphere (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ishibashi, Hiroshi</au><au>Hirano, Masashi</au><au>Matsumura, Naomi</au><au>Watanabe, Naoko</au><au>Takao, Yuji</au><au>Arizono, Koji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reproductive effects and bioconcentration of 4-nonylphenol in medaka fish ( Oryzias latipes)</atitle><jtitle>Chemosphere (Oxford)</jtitle><addtitle>Chemosphere</addtitle><date>2006-11-01</date><risdate>2006</risdate><volume>65</volume><issue>6</issue><spage>1019</spage><epage>1026</epage><pages>1019-1026</pages><issn>0045-6535</issn><eissn>1879-1298</eissn><coden>CMSHAF</coden><abstract>The objective of this study was to investigate the reproductive success (fertility and fecundity) of medaka (
Oryzias latipes) exposed to 4-nonylphenol (4-NP) in water and the viability of their F
1 offspring. In addition, we measured the bioconcentration of 4-NP in eggs. After a 21-d exposure to 100
μg/l 4-NP, medaka showed reduced egg production and fertility. Hepatic vitellogenin levels were increased significantly in males treated with 10, 50 and 100
μg/l of 4-NP. In the F
1 generations, the hatchability and time to hatching of embryos in the 100
μg/l treatment group were adversely affected, and 2–7
μg 4-NP/g egg was found in spawned eggs (the bioconcentration factor: 30–100). These results indicate that (1) 4-NP adversely affected the reproduction (fecundity and fertility) of adult medaka, (2) 4-NP accumulated in eggs through maternal transfer and (3) these levels of 4-NP were associated with adverse effects in the F
1 offspring.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>16677682</pmid><doi>10.1016/j.chemosphere.2006.03.034</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0045-6535 |
| ispartof | Chemosphere (Oxford), 2006-11, Vol.65 (6), p.1019-1026 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Agnatha. Pisces Animal, plant and microbial ecology Animals Applied ecology Bioconcentration Biological and medical sciences Dose-Response Relationship, Drug Ecotoxicology, biological effects of pollution Embryo, Nonmammalian - drug effects Embryo, Nonmammalian - physiology Female Freshwater Fundamental and applied biological sciences. Psychology General aspects Liver - drug effects Liver - metabolism Male Maternal transfer Medaka Nonylphenol Oryzias - physiology Oryzias latipes Ovum - drug effects Ovum - growth & development Phenols - toxicity Reproduction Reproduction - drug effects Reproduction - physiology Time Factors Toxicity Tests Vertebrates: general zoology, morphology, phylogeny, systematics, cytogenetics, geographical distribution Vitellogenins - analysis Vitellogenins - metabolism Water Pollutants, Chemical - toxicity |
| title | Reproductive effects and bioconcentration of 4-nonylphenol in medaka fish ( Oryzias latipes) |
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