Comparative in vitro metabolism of benzo[ a]pyrene by recombinant zebrafish CYP1A and liver microsomes from β-naphthoflavone-treated rainbow trout

The zebrafish ( Danio rerio) is a sensitive non-mammalian model used for studying polycyclic aromatic hydrocarbon (PAH)-induced chemical carcinogenesis. The susceptibility of zebrafish to PAH-induced carcinogenesis may be related to the ability of the zebrafish P450s to bioactivate these procarcinog...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Aquatic toxicology 2006-11, Vol.80 (2), p.101-108
Hauptverfasser:	Miranda, C.L., Chung, W.G., Wang-Buhler, J.-L., Musafia-Jeknic, T., Baird, W.M., Buhler, D.R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal, plant and microbial ecology Animals Applied ecology Benzo(a)pyrene - metabolism benzopyrene Biological and medical sciences biotransformation Carbon Isotopes - analysis CYP1A cytochrome P-450 Cytochrome P-450 Enzyme System - metabolism Cytochrome P450 Danio rerio DNA - metabolism DNA adducts DNA binding DNA-binding proteins Ecotoxicology, biological effects of pollution flavones Freshwater Fundamental and applied biological sciences. Psychology General aspects in vitro culture kinetics liver microsomes metabolites Microsomes, Liver - drug effects Microsomes, Liver - metabolism Oncorhynchus mykiss Oncorhynchus mykiss - metabolism oxidation Phosphorus Isotopes - analysis Protein Binding - drug effects Recombinant Proteins - metabolism Saccharomyces cerevisiae Zebrafish Zebrafish Proteins - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!