Crystal structure of glutamine amidotransferase from Pyrococcus horikoshii OT3
Glutamine amidotransferases (GATases) hydrolyze glutamine and generate ammonia. The glutamine amide nitrogen is utilized for the biosynthesis of a variety of molecules such as amino acids, coenzymes, antibiotics, purine and pyrimidine nucleotides, and glucosamine. Here, we determined the crystal str...
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| Veröffentlicht in: | Proceedings of the Japan Academy, Series B Series B, 2005, Vol.81(10), pp.459-462 |
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| container_title | Proceedings of the Japan Academy, Series B |
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| creator | MARUOKA, Shintaro LEE, Woo Cheol KAMO, Masayuki KUDO, Norio NAGATA, Koji TANOKURA, Masaru |
| description | Glutamine amidotransferases (GATases) hydrolyze glutamine and generate ammonia. The glutamine amide nitrogen is utilized for the biosynthesis of a variety of molecules such as amino acids, coenzymes, antibiotics, purine and pyrimidine nucleotides, and glucosamine. Here, we determined the crystal structure of a GATase (PH1346) from the hyperthermophilic archaeon Pyrococcus horikoshii OT3 at 1.89 Å resolution. Its overall structure and active site are the most similar to those of E. coli guanosine 5'-monophosphate (GMP) synthase and Sulfolobus solfataricus anthranilate synthase, respectively. (Communicated by Masanori OTSUKA, M.J.A.) |
| doi_str_mv | 10.2183/pjab.81.459 |
| format | Article |
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The glutamine amide nitrogen is utilized for the biosynthesis of a variety of molecules such as amino acids, coenzymes, antibiotics, purine and pyrimidine nucleotides, and glucosamine. Here, we determined the crystal structure of a GATase (PH1346) from the hyperthermophilic archaeon Pyrococcus horikoshii OT3 at 1.89 Å resolution. Its overall structure and active site are the most similar to those of E. coli guanosine 5'-monophosphate (GMP) synthase and Sulfolobus solfataricus anthranilate synthase, respectively. 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| subjects | Escherichia coli Glutamine amidotransferase protein structure Pyrococcus horikoshii Sulfolobus solfataricus X-ray crystallography |
| title | Crystal structure of glutamine amidotransferase from Pyrococcus horikoshii OT3 |
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