Atorvastatin attenuates experimental contrast-induced acute kidney injury: a role for TLR4/MyD88 signaling pathway

Objectives: To investigate the protective effect of different atorvastatin doses on contrast-induced acute kidney injury and the related mechanism. Methods: Healthy male Sprague-Dawley (SD) rats were randomly divided into the blank control group, experimental control group and different-dose atorvas...

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Veröffentlicht in:	Renal failure 2017-11, Vol.39 (1), p.643-651
Hauptverfasser:	Yue, Rongzheng, Zuo, Chuan, Zeng, Jing, Su, Baihai, Tao, Ye, Huang, Songmin, Zeng, Rui
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Kidney Injury - blood Acute Kidney Injury - chemically induced Acute Kidney Injury - prevention & control Animals Apoptosis Atorvastatin Atorvastatin - pharmacology Atorvastatin - therapeutic use Blood Urea Nitrogen Contrast Media - adverse effects Contrast-induced acute kidney injury Creatinine Creatinine - blood Disease Models, Animal Dose-Response Relationship, Drug Gene expression Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Inflammation Kidney Function Tests Kidney Tubules - drug effects Kidney Tubules - pathology Kidneys Laboratory Study Lymphocytes B Male MyD88 protein Myeloid Differentiation Factor 88 - metabolism NF-kappa B - metabolism NF-κB protein Rats Rats, Sprague-Dawley renal failure RNA, Messenger - metabolism Signal transduction Signal Transduction - drug effects signaling pathway TLR4 protein TLR4/MyD88 Toll-Like Receptor 4 - metabolism Toll-like receptors Urea
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