Atorvastatin attenuates experimental contrast-induced acute kidney injury: a role for TLR4/MyD88 signaling pathway
Objectives: To investigate the protective effect of different atorvastatin doses on contrast-induced acute kidney injury and the related mechanism. Methods: Healthy male Sprague-Dawley (SD) rats were randomly divided into the blank control group, experimental control group and different-dose atorvas...
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| creator | Yue, Rongzheng Zuo, Chuan Zeng, Jing Su, Baihai Tao, Ye Huang, Songmin Zeng, Rui |
| description | Objectives: To investigate the protective effect of different atorvastatin doses on contrast-induced acute kidney injury and the related mechanism.
Methods: Healthy male Sprague-Dawley (SD) rats were randomly divided into the blank control group, experimental control group and different-dose atorvastatin groups. A rat model of contrast-induced acute kidney injury was established. We detected changes in serum creatinine (Scr) and blood urea nitrogen (BUN) before and after model establishment, observed and scored renal tubular injury, analyzed rat renal cell apoptosis, and measure the expression of signal pathway proteins and downstream inflammatory factors.
Results: After contrast agent injection, the Scr and BUN levels of the experimental control group were significantly increased, the different doses applied in the atorvastatin group significantly reduced the Scr and BUN levels (p |
| doi_str_mv | 10.1080/0886022X.2017.1361838 |
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Methods: Healthy male Sprague-Dawley (SD) rats were randomly divided into the blank control group, experimental control group and different-dose atorvastatin groups. A rat model of contrast-induced acute kidney injury was established. We detected changes in serum creatinine (Scr) and blood urea nitrogen (BUN) before and after model establishment, observed and scored renal tubular injury, analyzed rat renal cell apoptosis, and measure the expression of signal pathway proteins and downstream inflammatory factors.
Results: After contrast agent injection, the Scr and BUN levels of the experimental control group were significantly increased, the different doses applied in the atorvastatin group significantly reduced the Scr and BUN levels (p < .05) and ameliorated the contrast-induced acute kidney injury (p < .05) and significantly reduced Toll-like receptor 4 (TLR4), Myeloid differentiation factor 88 (Myd88), and Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) protein expression and relative mRNA expression levels (p < .05) and significantly decreased expression levels of downstream inflammatory factors (p < .05).
Conclusion: Different atorvastatin doses have protective effects on contrast-induced acute renal tubular injury in rats, possibly by targeting TLR4, suppressing TLR4 expression, regulating the TLR4/Myd88 signaling pathway, and inhibiting the expression of downstream inflammatory factors.</description><identifier>ISSN: 0886-022X</identifier><identifier>EISSN: 1525-6049</identifier><identifier>DOI: 10.1080/0886022X.2017.1361838</identifier><identifier>PMID: 28805489</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>Acute Kidney Injury - blood ; Acute Kidney Injury - chemically induced ; Acute Kidney Injury - prevention & control ; Animals ; Apoptosis ; Atorvastatin ; Atorvastatin - pharmacology ; Atorvastatin - therapeutic use ; Blood Urea Nitrogen ; Contrast Media - adverse effects ; Contrast-induced acute kidney injury ; Creatinine ; Creatinine - blood ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Gene expression ; Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology ; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use ; Inflammation ; Kidney Function Tests ; Kidney Tubules - drug effects ; Kidney Tubules - pathology ; Kidneys ; Laboratory Study ; Lymphocytes B ; Male ; MyD88 protein ; Myeloid Differentiation Factor 88 - metabolism ; NF-kappa B - metabolism ; NF-κB protein ; Rats ; Rats, Sprague-Dawley ; renal failure ; RNA, Messenger - metabolism ; Signal transduction ; Signal Transduction - drug effects ; signaling pathway ; TLR4 protein ; TLR4/MyD88 ; Toll-Like Receptor 4 - metabolism ; Toll-like receptors ; Urea</subject><ispartof>Renal failure, 2017-11, Vol.39 (1), p.643-651</ispartof><rights>2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. 2017</rights><rights>2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This work is licensed under the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. 2017 The Author(s).</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c496t-7466f5b9439ed6077d7500a7dc8e138911a8cd84ed228ca91e561229e9d5e2ea3</citedby><cites>FETCH-LOGICAL-c496t-7466f5b9439ed6077d7500a7dc8e138911a8cd84ed228ca91e561229e9d5e2ea3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447912/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447912/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27479,27901,27902,53766,53768,59116,59117</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28805489$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yue, Rongzheng</creatorcontrib><creatorcontrib>Zuo, Chuan</creatorcontrib><creatorcontrib>Zeng, Jing</creatorcontrib><creatorcontrib>Su, Baihai</creatorcontrib><creatorcontrib>Tao, Ye</creatorcontrib><creatorcontrib>Huang, Songmin</creatorcontrib><creatorcontrib>Zeng, Rui</creatorcontrib><title>Atorvastatin attenuates experimental contrast-induced acute kidney injury: a role for TLR4/MyD88 signaling pathway</title><title>Renal failure</title><addtitle>Ren Fail</addtitle><description>Objectives: To investigate the protective effect of different atorvastatin doses on contrast-induced acute kidney injury and the related mechanism.
Methods: Healthy male Sprague-Dawley (SD) rats were randomly divided into the blank control group, experimental control group and different-dose atorvastatin groups. A rat model of contrast-induced acute kidney injury was established. We detected changes in serum creatinine (Scr) and blood urea nitrogen (BUN) before and after model establishment, observed and scored renal tubular injury, analyzed rat renal cell apoptosis, and measure the expression of signal pathway proteins and downstream inflammatory factors.
Results: After contrast agent injection, the Scr and BUN levels of the experimental control group were significantly increased, the different doses applied in the atorvastatin group significantly reduced the Scr and BUN levels (p < .05) and ameliorated the contrast-induced acute kidney injury (p < .05) and significantly reduced Toll-like receptor 4 (TLR4), Myeloid differentiation factor 88 (Myd88), and Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) protein expression and relative mRNA expression levels (p < .05) and significantly decreased expression levels of downstream inflammatory factors (p < .05).
Conclusion: Different atorvastatin doses have protective effects on contrast-induced acute renal tubular injury in rats, possibly by targeting TLR4, suppressing TLR4 expression, regulating the TLR4/Myd88 signaling pathway, and inhibiting the expression of downstream inflammatory factors.</description><subject>Acute Kidney Injury - blood</subject><subject>Acute Kidney Injury - chemically induced</subject><subject>Acute Kidney Injury - prevention & control</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>Atorvastatin</subject><subject>Atorvastatin - pharmacology</subject><subject>Atorvastatin - therapeutic use</subject><subject>Blood Urea Nitrogen</subject><subject>Contrast Media - adverse effects</subject><subject>Contrast-induced acute kidney injury</subject><subject>Creatinine</subject><subject>Creatinine - blood</subject><subject>Disease Models, Animal</subject><subject>Dose-Response Relationship, Drug</subject><subject>Gene expression</subject><subject>Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology</subject><subject>Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use</subject><subject>Inflammation</subject><subject>Kidney Function Tests</subject><subject>Kidney Tubules - drug effects</subject><subject>Kidney Tubules - pathology</subject><subject>Kidneys</subject><subject>Laboratory Study</subject><subject>Lymphocytes B</subject><subject>Male</subject><subject>MyD88 protein</subject><subject>Myeloid Differentiation Factor 88 - metabolism</subject><subject>NF-kappa B - metabolism</subject><subject>NF-κB protein</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>renal failure</subject><subject>RNA, Messenger - metabolism</subject><subject>Signal transduction</subject><subject>Signal Transduction - drug effects</subject><subject>signaling pathway</subject><subject>TLR4 protein</subject><subject>TLR4/MyD88</subject><subject>Toll-Like Receptor 4 - metabolism</subject><subject>Toll-like receptors</subject><subject>Urea</subject><issn>0886-022X</issn><issn>1525-6049</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>0YH</sourceid><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kc1u1DAURiMEokPhEUCW2LDJ1HbixGaBqEr5kQYhoSKxs27tm6mHjD21nbZ5exLNtAIWrLzwuZ_93VMULxldMirpCZWyoZz_XHLK2iWrGiYr-ahYMMFF2dBaPS4WM1PO0FHxLKUNpUzIlj8tjriUVNRSLYp4mkO8gZQhO08gZ_QDZEwE73YY3RZ9hp6Y4HOcoNJ5Oxi0BMyQkfxy1uNInN8McXxLgMTQI-lCJBer7_XJ1_GDlCS5tYfe-TXZQb66hfF58aSDPuGLw3lc_Ph4fnH2uVx9-_Tl7HRVmlo1uWzrpunEpaorhbahbWtbQSm01khklVSMgTRW1mg5lwYUQ9EwzhUqK5AjVMfFu33ubrjcojU4d-j1bmoFcdQBnP77xrsrvQ43uqnrVjE-Bbw5BMRwPWDKeuuSwb4Hj2FImikuWylUIyf09T_oJgxx6p00Z0pwqaiaKbGnTAwpRewePsOonq3qe6t6tqoPVqe5V382eZi61zgB7_eA89P2t3AbYm91hrEPsYvgjUu6-v8bvwE7mLOg</recordid><startdate>201711</startdate><enddate>201711</enddate><creator>Yue, Rongzheng</creator><creator>Zuo, Chuan</creator><creator>Zeng, Jing</creator><creator>Su, Baihai</creator><creator>Tao, Ye</creator><creator>Huang, Songmin</creator><creator>Zeng, Rui</creator><general>Taylor & Francis</general><general>Taylor & Francis Ltd</general><scope>0YH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7XB</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201711</creationdate><title>Atorvastatin attenuates experimental contrast-induced acute kidney injury: a role for TLR4/MyD88 signaling pathway</title><author>Yue, Rongzheng ; Zuo, Chuan ; Zeng, Jing ; Su, Baihai ; Tao, Ye ; Huang, Songmin ; Zeng, Rui</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c496t-7466f5b9439ed6077d7500a7dc8e138911a8cd84ed228ca91e561229e9d5e2ea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Acute Kidney Injury - blood</topic><topic>Acute Kidney Injury - chemically induced</topic><topic>Acute Kidney Injury - prevention & control</topic><topic>Animals</topic><topic>Apoptosis</topic><topic>Atorvastatin</topic><topic>Atorvastatin - pharmacology</topic><topic>Atorvastatin - therapeutic use</topic><topic>Blood Urea Nitrogen</topic><topic>Contrast Media - adverse effects</topic><topic>Contrast-induced acute kidney injury</topic><topic>Creatinine</topic><topic>Creatinine - blood</topic><topic>Disease Models, Animal</topic><topic>Dose-Response Relationship, Drug</topic><topic>Gene expression</topic><topic>Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology</topic><topic>Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use</topic><topic>Inflammation</topic><topic>Kidney Function Tests</topic><topic>Kidney Tubules - drug effects</topic><topic>Kidney Tubules - pathology</topic><topic>Kidneys</topic><topic>Laboratory Study</topic><topic>Lymphocytes B</topic><topic>Male</topic><topic>MyD88 protein</topic><topic>Myeloid Differentiation Factor 88 - metabolism</topic><topic>NF-kappa B - metabolism</topic><topic>NF-κB protein</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>renal failure</topic><topic>RNA, Messenger - metabolism</topic><topic>Signal transduction</topic><topic>Signal Transduction - drug effects</topic><topic>signaling pathway</topic><topic>TLR4 protein</topic><topic>TLR4/MyD88</topic><topic>Toll-Like Receptor 4 - metabolism</topic><topic>Toll-like receptors</topic><topic>Urea</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yue, Rongzheng</creatorcontrib><creatorcontrib>Zuo, Chuan</creatorcontrib><creatorcontrib>Zeng, Jing</creatorcontrib><creatorcontrib>Su, Baihai</creatorcontrib><creatorcontrib>Tao, Ye</creatorcontrib><creatorcontrib>Huang, Songmin</creatorcontrib><creatorcontrib>Zeng, Rui</creatorcontrib><collection>Taylor & Francis Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Renal failure</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yue, Rongzheng</au><au>Zuo, Chuan</au><au>Zeng, Jing</au><au>Su, Baihai</au><au>Tao, Ye</au><au>Huang, Songmin</au><au>Zeng, Rui</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Atorvastatin attenuates experimental contrast-induced acute kidney injury: a role for TLR4/MyD88 signaling pathway</atitle><jtitle>Renal failure</jtitle><addtitle>Ren Fail</addtitle><date>2017-11</date><risdate>2017</risdate><volume>39</volume><issue>1</issue><spage>643</spage><epage>651</epage><pages>643-651</pages><issn>0886-022X</issn><eissn>1525-6049</eissn><abstract>Objectives: To investigate the protective effect of different atorvastatin doses on contrast-induced acute kidney injury and the related mechanism.
Methods: Healthy male Sprague-Dawley (SD) rats were randomly divided into the blank control group, experimental control group and different-dose atorvastatin groups. A rat model of contrast-induced acute kidney injury was established. We detected changes in serum creatinine (Scr) and blood urea nitrogen (BUN) before and after model establishment, observed and scored renal tubular injury, analyzed rat renal cell apoptosis, and measure the expression of signal pathway proteins and downstream inflammatory factors.
Results: After contrast agent injection, the Scr and BUN levels of the experimental control group were significantly increased, the different doses applied in the atorvastatin group significantly reduced the Scr and BUN levels (p < .05) and ameliorated the contrast-induced acute kidney injury (p < .05) and significantly reduced Toll-like receptor 4 (TLR4), Myeloid differentiation factor 88 (Myd88), and Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) protein expression and relative mRNA expression levels (p < .05) and significantly decreased expression levels of downstream inflammatory factors (p < .05).
Conclusion: Different atorvastatin doses have protective effects on contrast-induced acute renal tubular injury in rats, possibly by targeting TLR4, suppressing TLR4 expression, regulating the TLR4/Myd88 signaling pathway, and inhibiting the expression of downstream inflammatory factors.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>28805489</pmid><doi>10.1080/0886022X.2017.1361838</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acute Kidney Injury - blood Acute Kidney Injury - chemically induced Acute Kidney Injury - prevention & control Animals Apoptosis Atorvastatin Atorvastatin - pharmacology Atorvastatin - therapeutic use Blood Urea Nitrogen Contrast Media - adverse effects Contrast-induced acute kidney injury Creatinine Creatinine - blood Disease Models, Animal Dose-Response Relationship, Drug Gene expression Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Inflammation Kidney Function Tests Kidney Tubules - drug effects Kidney Tubules - pathology Kidneys Laboratory Study Lymphocytes B Male MyD88 protein Myeloid Differentiation Factor 88 - metabolism NF-kappa B - metabolism NF-κB protein Rats Rats, Sprague-Dawley renal failure RNA, Messenger - metabolism Signal transduction Signal Transduction - drug effects signaling pathway TLR4 protein TLR4/MyD88 Toll-Like Receptor 4 - metabolism Toll-like receptors Urea |
| title | Atorvastatin attenuates experimental contrast-induced acute kidney injury: a role for TLR4/MyD88 signaling pathway |
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