Exploring the potential of T7 bacteriophage protein Gp2 as a novel inhibitor of mycobacterial RNA polymerase

Over the past six decades, there has been a decline in novel therapies to treat tuberculosis, while the causative agent of this disease has become increasingly resistant to current treatment regimens. Bacteriophages (phages) are able to kill bacterial cells and understanding this process could lead...

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Veröffentlicht in:	Tuberculosis (Edinburgh, Scotland) Scotland), 2017-09, Vol.106, p.82-90
Hauptverfasser:	du Plessis, J., Cloete, R., Burchell, L., Sarkar, P., Warren, R.M., Christoffels, A., Wigneshweraraj, S., Sampson, S.L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antitubercular Agents - chemistry Antitubercular Agents - pharmacology Bacteria Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism Bacteriophage T7 - enzymology Bacteriophage T7 - genetics DNA-directed RNA polymerase DNA-Directed RNA Polymerases - chemistry DNA-Directed RNA Polymerases - genetics DNA-Directed RNA Polymerases - metabolism Drug discovery Drug Discovery - methods Drugs E coli Electrophoretic mobility Escherichia coli - enzymology Escherichia coli - genetics Gene Expression Regulation, Bacterial Gene Expression Regulation, Enzymologic In silico analysis Medical treatment Molecular biology Molecular Dynamics Simulation Molecular modelling Mycobacterium tuberculosis Mycobacterium tuberculosis - enzymology Mycobacterium tuberculosis - genetics Mycobacterium tuberculosis - pathogenicity Phages Principal Component Analysis Protein Binding Protein Conformation Protein interaction Protein Interaction Domains and Motifs Proteins Repressor Proteins - chemistry Repressor Proteins - genetics Repressor Proteins - metabolism Ribonucleic acid RNA RNA polymerase T7 bacteriophage Transcription Transcription, Genetic Tuberculosis
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