Immunological response to nitroglycerin-loaded shear-responsive liposomes in vitro and in vivo

Liposomes formulated from the 1,3-diamidophospholipid Pad-PC-Pad are shear-responsive and thus promising nano-containers to specifically release a vasodilator at stenotic arteries. The recommended preclinical safety tests for therapeutic liposomes of nanometer size include the in vitro assessment of...

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Veröffentlicht in:	Journal of controlled release 2017-10, Vol.264, p.14-23
Hauptverfasser:	Buscema, Marzia, Matviykiv, Sofiya, Mészáros, Tamás, Gerganova, Gabriela, Weinberger, Andreas, Mettal, Ute, Mueller, Dennis, Neuhaus, Frederik, Stalder, Etienne, Ishikawa, Takashi, Urbanics, Rudolf, Saxer, Till, Pfohl, Thomas, Szebeni, János, Zumbuehl, Andreas, Müller, Bert
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biophysics Complement activation Complement Activation - drug effects Complement System Proteins - metabolism Drug delivery Humans Liposomes Male Metastable liposome Nanomedicine Nitroglycerin - administration & dosage Pathway Porcine model Serum Shear-responsive nano-container Swine
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