TGFβ/SMAD signalling modulates MLL and MLL-AF4 mediated 5-lipoxygenase promoter activation

•5-LO promoter activity is regulated by TGFβ and SMAD3/4.•TGFβ/Smads enhance MLL-mediated 5-LO promoter activation.•MLL-AF4-induced aberrant promoter activation is significantly reduced by TGFβ and SMAD3/4.•MEN1 and SP1 are essential for MLL-AF4 mediated 5-LO induction. 5-Lipoxygenase (5-LO) catalyz...

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Veröffentlicht in:	Prostaglandins & other lipid mediators 2017-11, Vol.133, p.60-67
Hauptverfasser:	Saul, Meike J., Groher, Florian, Hegewald, Anett B., Müller-McNicoll, Michaela, Marschalek, Rolf, Suess, Beatrix, Steinhilber, Dieter
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Lipoxygenase Arachidonate 5-Lipoxygenase - biosynthesis Arachidonate 5-Lipoxygenase - genetics Base Sequence Binding Sites Enzyme Induction Gene Knockdown Techniques HeLa Cells Histone-Lysine N-Methyltransferase - metabolism Humans Mixed lineage leukemia Myeloid-Lymphoid Leukemia Protein - metabolism Oncogene Proteins, Fusion - metabolism Promoter Promoter Regions, Genetic - genetics Signal Transduction Smad Proteins - metabolism Transforming Growth Factor beta - metabolism Transforming growth factor β
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