Staphylococcus aureus: the search for novel targets
New prophylaxis and therapeutic regimes are urgently required to combat Staphylococcus aureus, which causes hundreds of thousands of serious infections worldwide annually with a concomitant massive healthcare burden. In the UK, 20,000 cases of Staphylococcus aureus bacteraemia are reported each year...
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| Veröffentlicht in: | Drug discovery today 2005-05, Vol.10 (9), p.643-651 |
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| container_title | Drug discovery today |
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| creator | García-Lara, Jorge Masalha, Mahmud Foster, Simon J. |
| description | New prophylaxis and therapeutic regimes are urgently required to combat Staphylococcus aureus, which causes hundreds of thousands of serious infections worldwide annually with a concomitant massive healthcare burden.
In the UK, 20,000 cases of Staphylococcus aureus bacteraemia are reported each year, half of which are antibiotic resistant and ∼4% are fatal, exemplifying a worldwide phenomenon of tremendous economic and human impact. Novel treatments and prophylaxis are urgently required to combat such a serious threat. A common goal in the postgenomic era is to identify new targets for drug intervention (using small molecules) and immunologicals. Several promising cellular targets are now being developed in the quest to control such a life-threatening pathogen. |
| doi_str_mv | 10.1016/S1359-6446(05)03432-X |
| format | Article |
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In the UK, 20,000 cases of Staphylococcus aureus bacteraemia are reported each year, half of which are antibiotic resistant and ∼4% are fatal, exemplifying a worldwide phenomenon of tremendous economic and human impact. Novel treatments and prophylaxis are urgently required to combat such a serious threat. A common goal in the postgenomic era is to identify new targets for drug intervention (using small molecules) and immunologicals. Several promising cellular targets are now being developed in the quest to control such a life-threatening pathogen.</description><subject>Antibiotic</subject><subject>Antimicrobial</subject><subject>Bacterial Proteins - genetics</subject><subject>Biological and medical sciences</subject><subject>Drug Design</subject><subject>Drug Resistance, Multiple, Bacterial</subject><subject>General pharmacology</subject><subject>Humans</subject><subject>Immunologicals</subject><subject>Medical sciences</subject><subject>MRSA</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Prophylaxis</subject><subject>Staphylococcal Infections - drug therapy</subject><subject>Staphylococcus aureus</subject><subject>Staphylococcus aureus - drug effects</subject><subject>Staphylococcus aureus - genetics</subject><subject>Staphylococcus aureus - pathogenicity</subject><issn>1359-6446</issn><issn>1878-5832</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtKw0AUhgdRbK0-gpKNoovo3DNxI1K8QcFFFbobJpMTG0kzdSYp9O1N20iXrs5ZfP-5fAidE3xLMJF3U8JEGkvO5TUWN5hxRuPZARoSlahYKEYPu_4PGaCTEL4xJjQV8hgNiFAppzQdIjZtzHK-rpx11rYhMq2HNtxHzRyiAMbbeVQ4H9VuBVXUGP8FTThFR4WpApz1dYQ-n58-xq_x5P3lbfw4iS1LWRNLxSDnuc1pxjFJMC8ILmhiE2GAE4lVdwRlOMOyKJQQTPIs5YqpLE-J4EyyEbrazV1699NCaPSiDBaqytTg2qBJSpWQMulAsQOtdyF4KPTSlwvj15pgvbGlt7b0RoXGQm9t6VmXu-gXtNkC8n2q19MBlz1ggjVV4U1ty7DnuuUCd3-O0MOOg07HqgSvgy2htpCXHmyjc1f-c8ovEfCE2g</recordid><startdate>20050501</startdate><enddate>20050501</enddate><creator>García-Lara, Jorge</creator><creator>Masalha, Mahmud</creator><creator>Foster, Simon J.</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope></search><sort><creationdate>20050501</creationdate><title>Staphylococcus aureus: the search for novel targets</title><author>García-Lara, Jorge ; Masalha, Mahmud ; Foster, Simon J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c393t-683ed4dcd2b401704f10f27c75ae41608589230b06ff855364b94838bd9154363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Antibiotic</topic><topic>Antimicrobial</topic><topic>Bacterial Proteins - genetics</topic><topic>Biological and medical sciences</topic><topic>Drug Design</topic><topic>Drug Resistance, Multiple, Bacterial</topic><topic>General pharmacology</topic><topic>Humans</topic><topic>Immunologicals</topic><topic>Medical sciences</topic><topic>MRSA</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Prophylaxis</topic><topic>Staphylococcal Infections - drug therapy</topic><topic>Staphylococcus aureus</topic><topic>Staphylococcus aureus - drug effects</topic><topic>Staphylococcus aureus - genetics</topic><topic>Staphylococcus aureus - pathogenicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>García-Lara, Jorge</creatorcontrib><creatorcontrib>Masalha, Mahmud</creatorcontrib><creatorcontrib>Foster, Simon J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Drug discovery today</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>García-Lara, Jorge</au><au>Masalha, Mahmud</au><au>Foster, Simon J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Staphylococcus aureus: the search for novel targets</atitle><jtitle>Drug discovery today</jtitle><addtitle>Drug Discov Today</addtitle><date>2005-05-01</date><risdate>2005</risdate><volume>10</volume><issue>9</issue><spage>643</spage><epage>651</epage><pages>643-651</pages><issn>1359-6446</issn><eissn>1878-5832</eissn><abstract>New prophylaxis and therapeutic regimes are urgently required to combat Staphylococcus aureus, which causes hundreds of thousands of serious infections worldwide annually with a concomitant massive healthcare burden.
In the UK, 20,000 cases of Staphylococcus aureus bacteraemia are reported each year, half of which are antibiotic resistant and ∼4% are fatal, exemplifying a worldwide phenomenon of tremendous economic and human impact. Novel treatments and prophylaxis are urgently required to combat such a serious threat. A common goal in the postgenomic era is to identify new targets for drug intervention (using small molecules) and immunologicals. Several promising cellular targets are now being developed in the quest to control such a life-threatening pathogen.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>15894229</pmid><doi>10.1016/S1359-6446(05)03432-X</doi><tpages>9</tpages></addata></record> |
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| identifier | ISSN: 1359-6446 |
| ispartof | Drug discovery today, 2005-05, Vol.10 (9), p.643-651 |
| issn | 1359-6446 1878-5832 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Antibiotic Antimicrobial Bacterial Proteins - genetics Biological and medical sciences Drug Design Drug Resistance, Multiple, Bacterial General pharmacology Humans Immunologicals Medical sciences MRSA Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Prophylaxis Staphylococcal Infections - drug therapy Staphylococcus aureus Staphylococcus aureus - drug effects Staphylococcus aureus - genetics Staphylococcus aureus - pathogenicity |
| title | Staphylococcus aureus: the search for novel targets |
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