Taraxerol, a pentacyclic triterpenoid, from Abroma augusta leaf attenuates diabetic nephropathy in type 2 diabetic rats

Persistent hyperglycaemia coupled with inflammation plays an important role in the pathogenesis of diabetic nephropathy (DN). Present study examined the therapeutic potential of taraxerol isolated from the methanol extract of Abroma augusta leaf against DN using rodent model of type 2 diabetes (T2D)...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2017-10, Vol.94, p.726-741
Hauptverfasser:	Khanra, Ritu, Bhattacharjee, Niloy, Dua, Tarun K., Nandy, Ashis, Saha, Achintya, Kalita, Jatin, Manna, Prasenjit, Dewanjee, Saikat
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Computer Simulation Diabetes Mellitus, Experimental - complications Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - drug therapy Diabetic Nephropathies - prevention & control Disease Progression Hyperglycemia - complications Hyperglycemia - drug therapy Impaired glucose metabolism Inflammation Inflammation - drug therapy Inflammation - pathology Malvaceae - chemistry Molecular Docking Simulation Oleanolic Acid - analogs & derivatives Oleanolic Acid - isolation & purification Oleanolic Acid - pharmacology Phytoremediation Plant Leaves Rats Rats, Wistar Renal dysfunction Streptozocin Taraxerol Type 2 diabetes Up-Regulation - drug effects
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