Fluoxetine coupled with zinc in a chronic mild stress model of depression: Providing a reservoir for optimum zinc signaling and neuronal remodeling

Recently, depression has been envisioned as more than an alteration in neurotransmitters centered around receptor signaling pathways. Consequently, the precise mechanisms of selective serotonin reuptake inhibitor (SSRI) antidepressant drugs such as fluoxetine are being revisited. Zinc is a trace ele...

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Veröffentlicht in:	Pharmacology, biochemistry and behavior biochemistry and behavior, 2017-09, Vol.160, p.30-38
Hauptverfasser:	Omar, Nesreen Nabil, Tash, Reham Fathy
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antidepressive Agents, Second-Generation - administration & dosage Antidepressive Agents, Second-Generation - therapeutic use Brain - metabolism Chronic Disease CMS Corticosterone - blood Depression - drug therapy Depression - pathology Disease Models, Animal Fluoxetine Fluoxetine - administration & dosage Fluoxetine - therapeutic use Male Metallothioneins Neuronal plasticity Neurons - pathology Rats Rats, Sprague-Dawley Real-Time Polymerase Chain Reaction Serotonin - metabolism Signal Transduction Stress, Psychological Sucrose - administration & dosage Weight Gain - drug effects Zinc Zinc - administration & dosage Zinc - therapeutic use Zinc signaling
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