Fucosylated chondroitin sulfate oligosaccharides exert anticoagulant activity by targeting at intrinsic tenase complex with low FXII activation: Importance of sulfation pattern and molecular size

Fucosylated chondroitin sulfates (fCSs) are structurally unusual glycosaminoglycans isolated from sea cucumbers that exhibit potent anticoagulant activity. These fCSs were isolated from sea cucumber, Isostichopus badionotus and Pearsonothuria graeffei. Fenton reaction followed by gel filtration chro...

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Veröffentlicht in:	European journal of medicinal chemistry 2017-10, Vol.139, p.191-200
Hauptverfasser:	Li, Junhui, Li, Shan, Yan, Lufeng, Ding, Tian, Linhardt, Robert J., Yu, Yanlei, Liu, Xinyue, Liu, Donghong, Ye, Xingqian, Chen, Shiguo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anticoagulant Anticoagulants - chemical synthesis Anticoagulants - chemistry Anticoagulants - pharmacology Chondroitin Sulfates - chemical synthesis Chondroitin Sulfates - chemistry Chondroitin Sulfates - pharmacology Cysteine Endopeptidases - metabolism Depolymerization Dose-Response Relationship, Drug Factor Xa - metabolism Factor Xa Inhibitors - chemical synthesis Factor Xa Inhibitors - chemistry Factor Xa Inhibitors - pharmacology Factor XII - metabolism Fucosylated chondroitin sulfate Humans Male Molecular Structure Neoplasm Proteins - antagonists & inhibitors Neoplasm Proteins - metabolism Oligosaccharides - chemical synthesis Oligosaccharides - chemistry Oligosaccharides - pharmacology Sea cucumber Structure-Activity Relationship Young Adult
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