Positron emission tomography (PET) guided glioblastoma targeting by a fullerene-based nanoplatform with fast renal clearance
[Display omitted] Various carbonaceous nanomaterials, including fullerene, carbon nanotube, graphene, and carbon dots, have attracted increasing attention during past decades for their potential applications in biological imaging and therapy. In this study, we have developed a fullerene-based tumor-...
Gespeichert in:
| Veröffentlicht in: | Acta biomaterialia 2017-10, Vol.61, p.193-203 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 203 |
|---|---|
| container_issue | |
| container_start_page | 193 |
| container_title | Acta biomaterialia |
| container_volume | 61 |
| creator | Peng, Yayun Yang, Dongzhi Lu, Weifei Hu, Xiongwei Hong, Hao Cai, Ting |
| description | [Display omitted]
Various carbonaceous nanomaterials, including fullerene, carbon nanotube, graphene, and carbon dots, have attracted increasing attention during past decades for their potential applications in biological imaging and therapy. In this study, we have developed a fullerene-based tumor-targeted positron emission tomography (PET) imaging probe. Water-soluble functionalized C60 conjugates were radio-labeled with 64Cu and modified with cyclo (Arg-Gly-Asp) peptides (cRGD) for targeting of integrin αvβ3 in glioblastoma. The specificity of fluorescein-labeled C60 conjugates against cellular integrin αvβ3 was evaluated in U87MG (integrin αvβ3 positive) and MCF-7 cells (integrin αvβ3 negative) by confocal fluorescence microscopy and flow cytometry. Our results indicated that cRGD-conjugated C60 derivatives showed better cellular internalization compared with C60 derivatives without the cRGD attachment. Moreover, an interesting finding on intra-nuclei transportation of cRGD-conjugated C60 derivatives was observed in U87MG cells. In vivo serial PET studies showed preferential accumulation of cRGD-conjugated C60 derivatives at in U87MG tumors. In addition, the pharmacokinetic profiles of these fullerene-based nanoparticles conjugated with cRGD and 1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA) fit well with the three compartment model. The renal clearance of C60-based nanoparticles is remarkably fast, which makes this material very promising for safer cancer theranostic applications.
Safety is one of the major concerns for nanomedicine and nanomaterials with fast clearance profile are highly desirable. Fullerene is a distinct type of zero-dimensional carbon nanomaterial with ultrasmall size, uniform dispersity, and versatile reactivity. Here we have developed a fullerene-based tumor-targeted positron emission tomography imaging probe using water-soluble functionalized C60 conjugates radio-labeled with 64Cu and modified with cyclo (Arg-Gly-Asp) peptides (cRGD) for glioblastoma targeting. The improved tumor targeting property along with fast renal clearance behavior of C60-based nanoparticles makes this material very promising for future safer cancer theranostic applications. |
| doi_str_mv | 10.1016/j.actbio.2017.08.011 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1928515253</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1742706117305019</els_id><sourcerecordid>1964519401</sourcerecordid><originalsourceid>FETCH-LOGICAL-c390t-67d53a18f66650e562e6f747d9915f506d9b9adceb95e86a9f90629ca01f60233</originalsourceid><addsrcrecordid>eNp9kU1vFSEUhidGY2v1HxhD4qYuZgRmYGBjYpr6kTSxi7omDBym3DDDFZiam_jj5eZWFy5ccRKe93A4T9O8JrgjmPD3u06bMvnYUUzGDosOE_KkOSdiFO3IuHha63Gg7Yg5OWte5LzDuBeEiufNGRUCE8rFefPrNmZfUlwRLD5nX4sSlzgnvb8_oMvb67t3aN68BYvm4OMUdK73GhWdZih-ndF0QBq5LQRIsEI76VzZVa9xH3RxMS3opy_3yNUgqoQOyATQSa8GXjbPnA4ZXj2eF833T9d3V1_am2-fv159vGlNL3Fp-WhZr4lwnHOGgXEK3I3DaKUkzDHMrZyktgYmyUBwLZ3EnEqjMXEc076_aC5Pffcp_tggF1X_aiAEvULcsiKSCkYYZUf07T_oLm6pTn2k-MCIHDCp1HCiTIo5J3Bqn_yi00ERrI521E6d7KijHYWFqnZq7M1j821awP4N_dFRgQ8nAOo2HjwklY2HuinrE5iibPT_f-E3HVmjKQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1964519401</pqid></control><display><type>article</type><title>Positron emission tomography (PET) guided glioblastoma targeting by a fullerene-based nanoplatform with fast renal clearance</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Peng, Yayun ; Yang, Dongzhi ; Lu, Weifei ; Hu, Xiongwei ; Hong, Hao ; Cai, Ting</creator><creatorcontrib>Peng, Yayun ; Yang, Dongzhi ; Lu, Weifei ; Hu, Xiongwei ; Hong, Hao ; Cai, Ting</creatorcontrib><description>[Display omitted]
Various carbonaceous nanomaterials, including fullerene, carbon nanotube, graphene, and carbon dots, have attracted increasing attention during past decades for their potential applications in biological imaging and therapy. In this study, we have developed a fullerene-based tumor-targeted positron emission tomography (PET) imaging probe. Water-soluble functionalized C60 conjugates were radio-labeled with 64Cu and modified with cyclo (Arg-Gly-Asp) peptides (cRGD) for targeting of integrin αvβ3 in glioblastoma. The specificity of fluorescein-labeled C60 conjugates against cellular integrin αvβ3 was evaluated in U87MG (integrin αvβ3 positive) and MCF-7 cells (integrin αvβ3 negative) by confocal fluorescence microscopy and flow cytometry. Our results indicated that cRGD-conjugated C60 derivatives showed better cellular internalization compared with C60 derivatives without the cRGD attachment. Moreover, an interesting finding on intra-nuclei transportation of cRGD-conjugated C60 derivatives was observed in U87MG cells. In vivo serial PET studies showed preferential accumulation of cRGD-conjugated C60 derivatives at in U87MG tumors. In addition, the pharmacokinetic profiles of these fullerene-based nanoparticles conjugated with cRGD and 1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA) fit well with the three compartment model. The renal clearance of C60-based nanoparticles is remarkably fast, which makes this material very promising for safer cancer theranostic applications.
Safety is one of the major concerns for nanomedicine and nanomaterials with fast clearance profile are highly desirable. Fullerene is a distinct type of zero-dimensional carbon nanomaterial with ultrasmall size, uniform dispersity, and versatile reactivity. Here we have developed a fullerene-based tumor-targeted positron emission tomography imaging probe using water-soluble functionalized C60 conjugates radio-labeled with 64Cu and modified with cyclo (Arg-Gly-Asp) peptides (cRGD) for glioblastoma targeting. The improved tumor targeting property along with fast renal clearance behavior of C60-based nanoparticles makes this material very promising for future safer cancer theranostic applications.</description><identifier>ISSN: 1742-7061</identifier><identifier>EISSN: 1878-7568</identifier><identifier>DOI: 10.1016/j.actbio.2017.08.011</identifier><identifier>PMID: 28801268</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Buckminsterfullerene ; Cancer ; Cancer targeting ; Cancer therapies ; Carbon nanotubes ; Cell Line, Tumor ; Computer Simulation ; Conjugates ; Copper Radioisotopes - blood ; Copper Radioisotopes - chemistry ; Copper Radioisotopes - pharmacokinetics ; Cytometry ; Derivatives ; Emission analysis ; Female ; Flow cytometry ; Fluorescein ; Fluorescein - chemistry ; Fluorescence ; Fluorescence microscopy ; Fullerene ; Fullerenes ; Fullerenes - chemistry ; Fullerenes - pharmacokinetics ; Glioblastoma ; Glioblastoma - diagnostic imaging ; Humans ; In vivo methods and tests ; Integrin αvβ3 ; Internalization ; Kidney - metabolism ; Kidneys ; Mice, Nude ; Nanomaterials ; Nanoparticles ; Nanoparticles - chemistry ; Nanotechnology ; Nuclei ; Nuclei (cytology) ; Peptides ; Pharmacokinetics ; Pharmacology ; Positron emission ; Positron emission tomography ; Spectroscopy, Fourier Transform Infrared ; Time Factors ; Tissue Distribution ; Tomography ; Tumors</subject><ispartof>Acta biomaterialia, 2017-10, Vol.61, p.193-203</ispartof><rights>2017 Acta Materialia Inc.</rights><rights>Copyright © 2017 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.</rights><rights>Copyright Elsevier BV Oct 1, 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-67d53a18f66650e562e6f747d9915f506d9b9adceb95e86a9f90629ca01f60233</citedby><cites>FETCH-LOGICAL-c390t-67d53a18f66650e562e6f747d9915f506d9b9adceb95e86a9f90629ca01f60233</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1742706117305019$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28801268$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Peng, Yayun</creatorcontrib><creatorcontrib>Yang, Dongzhi</creatorcontrib><creatorcontrib>Lu, Weifei</creatorcontrib><creatorcontrib>Hu, Xiongwei</creatorcontrib><creatorcontrib>Hong, Hao</creatorcontrib><creatorcontrib>Cai, Ting</creatorcontrib><title>Positron emission tomography (PET) guided glioblastoma targeting by a fullerene-based nanoplatform with fast renal clearance</title><title>Acta biomaterialia</title><addtitle>Acta Biomater</addtitle><description>[Display omitted]
Various carbonaceous nanomaterials, including fullerene, carbon nanotube, graphene, and carbon dots, have attracted increasing attention during past decades for their potential applications in biological imaging and therapy. In this study, we have developed a fullerene-based tumor-targeted positron emission tomography (PET) imaging probe. Water-soluble functionalized C60 conjugates were radio-labeled with 64Cu and modified with cyclo (Arg-Gly-Asp) peptides (cRGD) for targeting of integrin αvβ3 in glioblastoma. The specificity of fluorescein-labeled C60 conjugates against cellular integrin αvβ3 was evaluated in U87MG (integrin αvβ3 positive) and MCF-7 cells (integrin αvβ3 negative) by confocal fluorescence microscopy and flow cytometry. Our results indicated that cRGD-conjugated C60 derivatives showed better cellular internalization compared with C60 derivatives without the cRGD attachment. Moreover, an interesting finding on intra-nuclei transportation of cRGD-conjugated C60 derivatives was observed in U87MG cells. In vivo serial PET studies showed preferential accumulation of cRGD-conjugated C60 derivatives at in U87MG tumors. In addition, the pharmacokinetic profiles of these fullerene-based nanoparticles conjugated with cRGD and 1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA) fit well with the three compartment model. The renal clearance of C60-based nanoparticles is remarkably fast, which makes this material very promising for safer cancer theranostic applications.
Safety is one of the major concerns for nanomedicine and nanomaterials with fast clearance profile are highly desirable. Fullerene is a distinct type of zero-dimensional carbon nanomaterial with ultrasmall size, uniform dispersity, and versatile reactivity. Here we have developed a fullerene-based tumor-targeted positron emission tomography imaging probe using water-soluble functionalized C60 conjugates radio-labeled with 64Cu and modified with cyclo (Arg-Gly-Asp) peptides (cRGD) for glioblastoma targeting. The improved tumor targeting property along with fast renal clearance behavior of C60-based nanoparticles makes this material very promising for future safer cancer theranostic applications.</description><subject>Animals</subject><subject>Buckminsterfullerene</subject><subject>Cancer</subject><subject>Cancer targeting</subject><subject>Cancer therapies</subject><subject>Carbon nanotubes</subject><subject>Cell Line, Tumor</subject><subject>Computer Simulation</subject><subject>Conjugates</subject><subject>Copper Radioisotopes - blood</subject><subject>Copper Radioisotopes - chemistry</subject><subject>Copper Radioisotopes - pharmacokinetics</subject><subject>Cytometry</subject><subject>Derivatives</subject><subject>Emission analysis</subject><subject>Female</subject><subject>Flow cytometry</subject><subject>Fluorescein</subject><subject>Fluorescein - chemistry</subject><subject>Fluorescence</subject><subject>Fluorescence microscopy</subject><subject>Fullerene</subject><subject>Fullerenes</subject><subject>Fullerenes - chemistry</subject><subject>Fullerenes - pharmacokinetics</subject><subject>Glioblastoma</subject><subject>Glioblastoma - diagnostic imaging</subject><subject>Humans</subject><subject>In vivo methods and tests</subject><subject>Integrin αvβ3</subject><subject>Internalization</subject><subject>Kidney - metabolism</subject><subject>Kidneys</subject><subject>Mice, Nude</subject><subject>Nanomaterials</subject><subject>Nanoparticles</subject><subject>Nanoparticles - chemistry</subject><subject>Nanotechnology</subject><subject>Nuclei</subject><subject>Nuclei (cytology)</subject><subject>Peptides</subject><subject>Pharmacokinetics</subject><subject>Pharmacology</subject><subject>Positron emission</subject><subject>Positron emission tomography</subject><subject>Spectroscopy, Fourier Transform Infrared</subject><subject>Time Factors</subject><subject>Tissue Distribution</subject><subject>Tomography</subject><subject>Tumors</subject><issn>1742-7061</issn><issn>1878-7568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1vFSEUhidGY2v1HxhD4qYuZgRmYGBjYpr6kTSxi7omDBym3DDDFZiam_jj5eZWFy5ccRKe93A4T9O8JrgjmPD3u06bMvnYUUzGDosOE_KkOSdiFO3IuHha63Gg7Yg5OWte5LzDuBeEiufNGRUCE8rFefPrNmZfUlwRLD5nX4sSlzgnvb8_oMvb67t3aN68BYvm4OMUdK73GhWdZih-ndF0QBq5LQRIsEI76VzZVa9xH3RxMS3opy_3yNUgqoQOyATQSa8GXjbPnA4ZXj2eF833T9d3V1_am2-fv159vGlNL3Fp-WhZr4lwnHOGgXEK3I3DaKUkzDHMrZyktgYmyUBwLZ3EnEqjMXEc076_aC5Pffcp_tggF1X_aiAEvULcsiKSCkYYZUf07T_oLm6pTn2k-MCIHDCp1HCiTIo5J3Bqn_yi00ERrI521E6d7KijHYWFqnZq7M1j821awP4N_dFRgQ8nAOo2HjwklY2HuinrE5iibPT_f-E3HVmjKQ</recordid><startdate>20171001</startdate><enddate>20171001</enddate><creator>Peng, Yayun</creator><creator>Yang, Dongzhi</creator><creator>Lu, Weifei</creator><creator>Hu, Xiongwei</creator><creator>Hong, Hao</creator><creator>Cai, Ting</creator><general>Elsevier Ltd</general><general>Elsevier BV</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20171001</creationdate><title>Positron emission tomography (PET) guided glioblastoma targeting by a fullerene-based nanoplatform with fast renal clearance</title><author>Peng, Yayun ; Yang, Dongzhi ; Lu, Weifei ; Hu, Xiongwei ; Hong, Hao ; Cai, Ting</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-67d53a18f66650e562e6f747d9915f506d9b9adceb95e86a9f90629ca01f60233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Buckminsterfullerene</topic><topic>Cancer</topic><topic>Cancer targeting</topic><topic>Cancer therapies</topic><topic>Carbon nanotubes</topic><topic>Cell Line, Tumor</topic><topic>Computer Simulation</topic><topic>Conjugates</topic><topic>Copper Radioisotopes - blood</topic><topic>Copper Radioisotopes - chemistry</topic><topic>Copper Radioisotopes - pharmacokinetics</topic><topic>Cytometry</topic><topic>Derivatives</topic><topic>Emission analysis</topic><topic>Female</topic><topic>Flow cytometry</topic><topic>Fluorescein</topic><topic>Fluorescein - chemistry</topic><topic>Fluorescence</topic><topic>Fluorescence microscopy</topic><topic>Fullerene</topic><topic>Fullerenes</topic><topic>Fullerenes - chemistry</topic><topic>Fullerenes - pharmacokinetics</topic><topic>Glioblastoma</topic><topic>Glioblastoma - diagnostic imaging</topic><topic>Humans</topic><topic>In vivo methods and tests</topic><topic>Integrin αvβ3</topic><topic>Internalization</topic><topic>Kidney - metabolism</topic><topic>Kidneys</topic><topic>Mice, Nude</topic><topic>Nanomaterials</topic><topic>Nanoparticles</topic><topic>Nanoparticles - chemistry</topic><topic>Nanotechnology</topic><topic>Nuclei</topic><topic>Nuclei (cytology)</topic><topic>Peptides</topic><topic>Pharmacokinetics</topic><topic>Pharmacology</topic><topic>Positron emission</topic><topic>Positron emission tomography</topic><topic>Spectroscopy, Fourier Transform Infrared</topic><topic>Time Factors</topic><topic>Tissue Distribution</topic><topic>Tomography</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Peng, Yayun</creatorcontrib><creatorcontrib>Yang, Dongzhi</creatorcontrib><creatorcontrib>Lu, Weifei</creatorcontrib><creatorcontrib>Hu, Xiongwei</creatorcontrib><creatorcontrib>Hong, Hao</creatorcontrib><creatorcontrib>Cai, Ting</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Acta biomaterialia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Peng, Yayun</au><au>Yang, Dongzhi</au><au>Lu, Weifei</au><au>Hu, Xiongwei</au><au>Hong, Hao</au><au>Cai, Ting</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Positron emission tomography (PET) guided glioblastoma targeting by a fullerene-based nanoplatform with fast renal clearance</atitle><jtitle>Acta biomaterialia</jtitle><addtitle>Acta Biomater</addtitle><date>2017-10-01</date><risdate>2017</risdate><volume>61</volume><spage>193</spage><epage>203</epage><pages>193-203</pages><issn>1742-7061</issn><eissn>1878-7568</eissn><abstract>[Display omitted]
Various carbonaceous nanomaterials, including fullerene, carbon nanotube, graphene, and carbon dots, have attracted increasing attention during past decades for their potential applications in biological imaging and therapy. In this study, we have developed a fullerene-based tumor-targeted positron emission tomography (PET) imaging probe. Water-soluble functionalized C60 conjugates were radio-labeled with 64Cu and modified with cyclo (Arg-Gly-Asp) peptides (cRGD) for targeting of integrin αvβ3 in glioblastoma. The specificity of fluorescein-labeled C60 conjugates against cellular integrin αvβ3 was evaluated in U87MG (integrin αvβ3 positive) and MCF-7 cells (integrin αvβ3 negative) by confocal fluorescence microscopy and flow cytometry. Our results indicated that cRGD-conjugated C60 derivatives showed better cellular internalization compared with C60 derivatives without the cRGD attachment. Moreover, an interesting finding on intra-nuclei transportation of cRGD-conjugated C60 derivatives was observed in U87MG cells. In vivo serial PET studies showed preferential accumulation of cRGD-conjugated C60 derivatives at in U87MG tumors. In addition, the pharmacokinetic profiles of these fullerene-based nanoparticles conjugated with cRGD and 1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA) fit well with the three compartment model. The renal clearance of C60-based nanoparticles is remarkably fast, which makes this material very promising for safer cancer theranostic applications.
Safety is one of the major concerns for nanomedicine and nanomaterials with fast clearance profile are highly desirable. Fullerene is a distinct type of zero-dimensional carbon nanomaterial with ultrasmall size, uniform dispersity, and versatile reactivity. Here we have developed a fullerene-based tumor-targeted positron emission tomography imaging probe using water-soluble functionalized C60 conjugates radio-labeled with 64Cu and modified with cyclo (Arg-Gly-Asp) peptides (cRGD) for glioblastoma targeting. The improved tumor targeting property along with fast renal clearance behavior of C60-based nanoparticles makes this material very promising for future safer cancer theranostic applications.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>28801268</pmid><doi>10.1016/j.actbio.2017.08.011</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1742-7061 |
| ispartof | Acta biomaterialia, 2017-10, Vol.61, p.193-203 |
| issn | 1742-7061 1878-7568 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1928515253 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Buckminsterfullerene Cancer Cancer targeting Cancer therapies Carbon nanotubes Cell Line, Tumor Computer Simulation Conjugates Copper Radioisotopes - blood Copper Radioisotopes - chemistry Copper Radioisotopes - pharmacokinetics Cytometry Derivatives Emission analysis Female Flow cytometry Fluorescein Fluorescein - chemistry Fluorescence Fluorescence microscopy Fullerene Fullerenes Fullerenes - chemistry Fullerenes - pharmacokinetics Glioblastoma Glioblastoma - diagnostic imaging Humans In vivo methods and tests Integrin αvβ3 Internalization Kidney - metabolism Kidneys Mice, Nude Nanomaterials Nanoparticles Nanoparticles - chemistry Nanotechnology Nuclei Nuclei (cytology) Peptides Pharmacokinetics Pharmacology Positron emission Positron emission tomography Spectroscopy, Fourier Transform Infrared Time Factors Tissue Distribution Tomography Tumors |
| title | Positron emission tomography (PET) guided glioblastoma targeting by a fullerene-based nanoplatform with fast renal clearance |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T04%3A50%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Positron%20emission%20tomography%20(PET)%20guided%20glioblastoma%20targeting%20by%20a%20fullerene-based%20nanoplatform%20with%20fast%20renal%20clearance&rft.jtitle=Acta%20biomaterialia&rft.au=Peng,%20Yayun&rft.date=2017-10-01&rft.volume=61&rft.spage=193&rft.epage=203&rft.pages=193-203&rft.issn=1742-7061&rft.eissn=1878-7568&rft_id=info:doi/10.1016/j.actbio.2017.08.011&rft_dat=%3Cproquest_cross%3E1964519401%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1964519401&rft_id=info:pmid/28801268&rft_els_id=S1742706117305019&rfr_iscdi=true |