Simple and rapid determination of zaltoprofen in human plasma by manual‐shaking‐assisted dispersive liquid–liquid microextraction followed by liquid chromatography with ultraviolet detection
A readily applicable method was developed to determine the concentration level of zaltoprofen, a non‐steroidal antiinflammatory drug from the propionic acid family, in human plasma. This method is based on manual‐shaking‐assisted dispersive liquid–liquid microextraction coupled with liquid chromatog...
Gespeichert in:
| Veröffentlicht in: | Journal of separation science 2017-10, Vol.40 (20), p.4050-4059 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 4059 |
|---|---|
| container_issue | 20 |
| container_start_page | 4050 |
| container_title | Journal of separation science |
| container_volume | 40 |
| creator | Han, Se Young Jeong, Kyung Min Yoo, Da Eun Jin, Yan Kim, Eun Mi Kim, Su Hyun Lee, Seok‐Yong Kim, Se‐Hyung Zhao, Jing Lee, Jeongmi |
| description | A readily applicable method was developed to determine the concentration level of zaltoprofen, a non‐steroidal antiinflammatory drug from the propionic acid family, in human plasma. This method is based on manual‐shaking‐assisted dispersive liquid–liquid microextraction coupled with liquid chromatography with ultraviolet detection. Factors affecting the extraction efficiency were screened and optimized by experimental design using fractional factorial and central composite designs, respectively. Optimal conditions were: 220 μL of C2H4Cl2 (extraction solvent), 5 mL of 3.75% w/v NaCl aqueous solution at pH 2.0, and manual shaking for 13 s (65 times). The resulting extraction method yielded a reasonable enrichment factor of 18.0 (±0.6, n = 3) and extraction recovery of 86.0% (±3.3%, n = 3). The established method was validated for selectivity, linearity, precision, accuracy, matrix effect, recovery, dilution integrity, and stability, and it met the acceptable criteria for all of the tested parameters. Specifically, the method was linear in the range of 0.16–50.0 mg/L, precise ( |
| doi_str_mv | 10.1002/jssc.201700451 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1928515034</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1928515034</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4052-d6248c4de9e08f7a09b9c314afd6559836d441792049eab53428b64ea3d650d53</originalsourceid><addsrcrecordid>eNqFkc1u1DAUhSMEoqWwZYkssWEzU9uxM_ESjfgpqtTFwDq6iW8aD3ac2kmHYdVHQOKV-iR9EtyZYRZsWPlY_s7x1T1Z9prROaOUn69jbOacsgWlQrIn2SkrmJypnImnR02Lk-xFjGuasFLR59kJL0vKKZen2f3KuMEigV6TAIPRROOIwZkeRuN74lvyE-zoh-Bb7InpSTc56MlgITog9Zak2wT24e5X7OC76a-TghhNHDFlmThgiOYWiTU3k9EPd7_3gjjTBI8_xgDN7qPWW-s3yZMiD0jTBe9g9NdpsG5LNmbsyGST49Z4i-Nu0p35ZfasBRvx1eE8y759_PB1-Xl2efXpYvn-ctYIKvlMF1yUjdCokJbtAqiqVZM2Ba0upFRlXmgh2EJxKhRCLXPBy7oQCHl6p1rmZ9m7fW7axs2EcayciQ1aCz36KVZM8VIySXOR0Lf_oGs_hT5NlygppGS5yhM131NpFzEGbKshGAdhWzFaPfZbPfZbHftNhjeH2Kl2qI_430ITIPbAxljc_ieu-rJaLWXBef4HBFC52g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1954551393</pqid></control><display><type>article</type><title>Simple and rapid determination of zaltoprofen in human plasma by manual‐shaking‐assisted dispersive liquid–liquid microextraction followed by liquid chromatography with ultraviolet detection</title><source>Wiley Online Library Journals Frontfile Complete</source><creator>Han, Se Young ; Jeong, Kyung Min ; Yoo, Da Eun ; Jin, Yan ; Kim, Eun Mi ; Kim, Su Hyun ; Lee, Seok‐Yong ; Kim, Se‐Hyung ; Zhao, Jing ; Lee, Jeongmi</creator><creatorcontrib>Han, Se Young ; Jeong, Kyung Min ; Yoo, Da Eun ; Jin, Yan ; Kim, Eun Mi ; Kim, Su Hyun ; Lee, Seok‐Yong ; Kim, Se‐Hyung ; Zhao, Jing ; Lee, Jeongmi</creatorcontrib><description>A readily applicable method was developed to determine the concentration level of zaltoprofen, a non‐steroidal antiinflammatory drug from the propionic acid family, in human plasma. This method is based on manual‐shaking‐assisted dispersive liquid–liquid microextraction coupled with liquid chromatography with ultraviolet detection. Factors affecting the extraction efficiency were screened and optimized by experimental design using fractional factorial and central composite designs, respectively. Optimal conditions were: 220 μL of C2H4Cl2 (extraction solvent), 5 mL of 3.75% w/v NaCl aqueous solution at pH 2.0, and manual shaking for 13 s (65 times). The resulting extraction method yielded a reasonable enrichment factor of 18.0 (±0.6, n = 3) and extraction recovery of 86.0% (±3.3%, n = 3). The established method was validated for selectivity, linearity, precision, accuracy, matrix effect, recovery, dilution integrity, and stability, and it met the acceptable criteria for all of the tested parameters. Specifically, the method was linear in the range of 0.16–50.0 mg/L, precise (< 8.8% RSD), accurate (–7.5–5.6% deviation), and showed negligible matrix effects (96.1–106.4%) with high absolute recovery (94.5–97.7%). Compared with previous methods involving labor‐intensive liquid–liquid extraction or non‐specific protein precipitation, our method allows the simple, rapid, and efficient determination of zaltoprofen using the most affordable analytical instrument, liquid chromatography with ultraviolet detection.</description><identifier>ISSN: 1615-9306</identifier><identifier>EISSN: 1615-9314</identifier><identifier>DOI: 10.1002/jssc.201700451</identifier><identifier>PMID: 28802025</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Blood plasma ; Chromatography ; Design optimization ; Dilution ; Dispersion ; dispersive liquid‐liquid microextraction ; experimental design ; human plasma ; Linearity ; Liquid-liquid extraction ; Mathematical analysis ; Propionic acid ; Recovery ; Selectivity ; Shaking ; Stability criteria ; Ultraviolet ; zaltoprofen</subject><ispartof>Journal of separation science, 2017-10, Vol.40 (20), p.4050-4059</ispartof><rights>2017 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><rights>2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4052-d6248c4de9e08f7a09b9c314afd6559836d441792049eab53428b64ea3d650d53</citedby><cites>FETCH-LOGICAL-c4052-d6248c4de9e08f7a09b9c314afd6559836d441792049eab53428b64ea3d650d53</cites><orcidid>0000-0002-9948-7554</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjssc.201700451$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjssc.201700451$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28802025$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Han, Se Young</creatorcontrib><creatorcontrib>Jeong, Kyung Min</creatorcontrib><creatorcontrib>Yoo, Da Eun</creatorcontrib><creatorcontrib>Jin, Yan</creatorcontrib><creatorcontrib>Kim, Eun Mi</creatorcontrib><creatorcontrib>Kim, Su Hyun</creatorcontrib><creatorcontrib>Lee, Seok‐Yong</creatorcontrib><creatorcontrib>Kim, Se‐Hyung</creatorcontrib><creatorcontrib>Zhao, Jing</creatorcontrib><creatorcontrib>Lee, Jeongmi</creatorcontrib><title>Simple and rapid determination of zaltoprofen in human plasma by manual‐shaking‐assisted dispersive liquid–liquid microextraction followed by liquid chromatography with ultraviolet detection</title><title>Journal of separation science</title><addtitle>J Sep Sci</addtitle><description>A readily applicable method was developed to determine the concentration level of zaltoprofen, a non‐steroidal antiinflammatory drug from the propionic acid family, in human plasma. This method is based on manual‐shaking‐assisted dispersive liquid–liquid microextraction coupled with liquid chromatography with ultraviolet detection. Factors affecting the extraction efficiency were screened and optimized by experimental design using fractional factorial and central composite designs, respectively. Optimal conditions were: 220 μL of C2H4Cl2 (extraction solvent), 5 mL of 3.75% w/v NaCl aqueous solution at pH 2.0, and manual shaking for 13 s (65 times). The resulting extraction method yielded a reasonable enrichment factor of 18.0 (±0.6, n = 3) and extraction recovery of 86.0% (±3.3%, n = 3). The established method was validated for selectivity, linearity, precision, accuracy, matrix effect, recovery, dilution integrity, and stability, and it met the acceptable criteria for all of the tested parameters. Specifically, the method was linear in the range of 0.16–50.0 mg/L, precise (< 8.8% RSD), accurate (–7.5–5.6% deviation), and showed negligible matrix effects (96.1–106.4%) with high absolute recovery (94.5–97.7%). Compared with previous methods involving labor‐intensive liquid–liquid extraction or non‐specific protein precipitation, our method allows the simple, rapid, and efficient determination of zaltoprofen using the most affordable analytical instrument, liquid chromatography with ultraviolet detection.</description><subject>Blood plasma</subject><subject>Chromatography</subject><subject>Design optimization</subject><subject>Dilution</subject><subject>Dispersion</subject><subject>dispersive liquid‐liquid microextraction</subject><subject>experimental design</subject><subject>human plasma</subject><subject>Linearity</subject><subject>Liquid-liquid extraction</subject><subject>Mathematical analysis</subject><subject>Propionic acid</subject><subject>Recovery</subject><subject>Selectivity</subject><subject>Shaking</subject><subject>Stability criteria</subject><subject>Ultraviolet</subject><subject>zaltoprofen</subject><issn>1615-9306</issn><issn>1615-9314</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNqFkc1u1DAUhSMEoqWwZYkssWEzU9uxM_ESjfgpqtTFwDq6iW8aD3ac2kmHYdVHQOKV-iR9EtyZYRZsWPlY_s7x1T1Z9prROaOUn69jbOacsgWlQrIn2SkrmJypnImnR02Lk-xFjGuasFLR59kJL0vKKZen2f3KuMEigV6TAIPRROOIwZkeRuN74lvyE-zoh-Bb7InpSTc56MlgITog9Zak2wT24e5X7OC76a-TghhNHDFlmThgiOYWiTU3k9EPd7_3gjjTBI8_xgDN7qPWW-s3yZMiD0jTBe9g9NdpsG5LNmbsyGST49Z4i-Nu0p35ZfasBRvx1eE8y759_PB1-Xl2efXpYvn-ctYIKvlMF1yUjdCokJbtAqiqVZM2Ba0upFRlXmgh2EJxKhRCLXPBy7oQCHl6p1rmZ9m7fW7axs2EcayciQ1aCz36KVZM8VIySXOR0Lf_oGs_hT5NlygppGS5yhM131NpFzEGbKshGAdhWzFaPfZbPfZbHftNhjeH2Kl2qI_430ITIPbAxljc_ieu-rJaLWXBef4HBFC52g</recordid><startdate>201710</startdate><enddate>201710</enddate><creator>Han, Se Young</creator><creator>Jeong, Kyung Min</creator><creator>Yoo, Da Eun</creator><creator>Jin, Yan</creator><creator>Kim, Eun Mi</creator><creator>Kim, Su Hyun</creator><creator>Lee, Seok‐Yong</creator><creator>Kim, Se‐Hyung</creator><creator>Zhao, Jing</creator><creator>Lee, Jeongmi</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9948-7554</orcidid></search><sort><creationdate>201710</creationdate><title>Simple and rapid determination of zaltoprofen in human plasma by manual‐shaking‐assisted dispersive liquid–liquid microextraction followed by liquid chromatography with ultraviolet detection</title><author>Han, Se Young ; Jeong, Kyung Min ; Yoo, Da Eun ; Jin, Yan ; Kim, Eun Mi ; Kim, Su Hyun ; Lee, Seok‐Yong ; Kim, Se‐Hyung ; Zhao, Jing ; Lee, Jeongmi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4052-d6248c4de9e08f7a09b9c314afd6559836d441792049eab53428b64ea3d650d53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Blood plasma</topic><topic>Chromatography</topic><topic>Design optimization</topic><topic>Dilution</topic><topic>Dispersion</topic><topic>dispersive liquid‐liquid microextraction</topic><topic>experimental design</topic><topic>human plasma</topic><topic>Linearity</topic><topic>Liquid-liquid extraction</topic><topic>Mathematical analysis</topic><topic>Propionic acid</topic><topic>Recovery</topic><topic>Selectivity</topic><topic>Shaking</topic><topic>Stability criteria</topic><topic>Ultraviolet</topic><topic>zaltoprofen</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Han, Se Young</creatorcontrib><creatorcontrib>Jeong, Kyung Min</creatorcontrib><creatorcontrib>Yoo, Da Eun</creatorcontrib><creatorcontrib>Jin, Yan</creatorcontrib><creatorcontrib>Kim, Eun Mi</creatorcontrib><creatorcontrib>Kim, Su Hyun</creatorcontrib><creatorcontrib>Lee, Seok‐Yong</creatorcontrib><creatorcontrib>Kim, Se‐Hyung</creatorcontrib><creatorcontrib>Zhao, Jing</creatorcontrib><creatorcontrib>Lee, Jeongmi</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of separation science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Han, Se Young</au><au>Jeong, Kyung Min</au><au>Yoo, Da Eun</au><au>Jin, Yan</au><au>Kim, Eun Mi</au><au>Kim, Su Hyun</au><au>Lee, Seok‐Yong</au><au>Kim, Se‐Hyung</au><au>Zhao, Jing</au><au>Lee, Jeongmi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Simple and rapid determination of zaltoprofen in human plasma by manual‐shaking‐assisted dispersive liquid–liquid microextraction followed by liquid chromatography with ultraviolet detection</atitle><jtitle>Journal of separation science</jtitle><addtitle>J Sep Sci</addtitle><date>2017-10</date><risdate>2017</risdate><volume>40</volume><issue>20</issue><spage>4050</spage><epage>4059</epage><pages>4050-4059</pages><issn>1615-9306</issn><eissn>1615-9314</eissn><abstract>A readily applicable method was developed to determine the concentration level of zaltoprofen, a non‐steroidal antiinflammatory drug from the propionic acid family, in human plasma. This method is based on manual‐shaking‐assisted dispersive liquid–liquid microextraction coupled with liquid chromatography with ultraviolet detection. Factors affecting the extraction efficiency were screened and optimized by experimental design using fractional factorial and central composite designs, respectively. Optimal conditions were: 220 μL of C2H4Cl2 (extraction solvent), 5 mL of 3.75% w/v NaCl aqueous solution at pH 2.0, and manual shaking for 13 s (65 times). The resulting extraction method yielded a reasonable enrichment factor of 18.0 (±0.6, n = 3) and extraction recovery of 86.0% (±3.3%, n = 3). The established method was validated for selectivity, linearity, precision, accuracy, matrix effect, recovery, dilution integrity, and stability, and it met the acceptable criteria for all of the tested parameters. Specifically, the method was linear in the range of 0.16–50.0 mg/L, precise (< 8.8% RSD), accurate (–7.5–5.6% deviation), and showed negligible matrix effects (96.1–106.4%) with high absolute recovery (94.5–97.7%). Compared with previous methods involving labor‐intensive liquid–liquid extraction or non‐specific protein precipitation, our method allows the simple, rapid, and efficient determination of zaltoprofen using the most affordable analytical instrument, liquid chromatography with ultraviolet detection.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>28802025</pmid><doi>10.1002/jssc.201700451</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-9948-7554</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1615-9306 |
| ispartof | Journal of separation science, 2017-10, Vol.40 (20), p.4050-4059 |
| issn | 1615-9306 1615-9314 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1928515034 |
| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Blood plasma Chromatography Design optimization Dilution Dispersion dispersive liquid‐liquid microextraction experimental design human plasma Linearity Liquid-liquid extraction Mathematical analysis Propionic acid Recovery Selectivity Shaking Stability criteria Ultraviolet zaltoprofen |
| title | Simple and rapid determination of zaltoprofen in human plasma by manual‐shaking‐assisted dispersive liquid–liquid microextraction followed by liquid chromatography with ultraviolet detection |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T20%3A55%3A57IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Simple%20and%20rapid%20determination%20of%20zaltoprofen%20in%20human%20plasma%20by%20manual%E2%80%90shaking%E2%80%90assisted%20dispersive%20liquid%E2%80%93liquid%20microextraction%20followed%20by%20liquid%20chromatography%20with%20ultraviolet%20detection&rft.jtitle=Journal%20of%20separation%20science&rft.au=Han,%20Se%20Young&rft.date=2017-10&rft.volume=40&rft.issue=20&rft.spage=4050&rft.epage=4059&rft.pages=4050-4059&rft.issn=1615-9306&rft.eissn=1615-9314&rft_id=info:doi/10.1002/jssc.201700451&rft_dat=%3Cproquest_cross%3E1928515034%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1954551393&rft_id=info:pmid/28802025&rfr_iscdi=true |