Pmepa1 induced by RANKL‐p38 MAPK pathway has a novel role in osteoclastogenesis

Osteoclasts are multinucleated cells formed by fusion of preosteoclasts (POCs) derived from cells of the monocyte/macrophage lineage. We have reported a culture system that supports the formation of POCs from stroma‐depleted rat bone marrow cells. Global gene expression analysis of this culture syst...

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Veröffentlicht in:	Journal of cellular physiology 2018-04, Vol.233 (4), p.3105-3118
Hauptverfasser:	Funakubo, Noboru, Xu, Xianghe, Kukita, Toshio, Nakamura, Seiji, Miyamoto, Hiroshi, Kukita, Akiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biocompatibility Bone marrow Bone Marrow Cells - drug effects Bone Marrow Cells - metabolism c-Fos protein Cathepsin K Cell culture Cell Differentiation - drug effects Cell surface Cells, Cultured Delta cells Gene expression Genes Humans Interleukin-1beta - pharmacology Intracellular Leukocytes (mononuclear) Macrophages Male MAP kinase MAP Kinase Signaling System - drug effects MAPK Membrane Proteins - metabolism Mice, Inbred C57BL Monocytes Nedd4 Ubiquitin Protein Ligases - metabolism osteoclast Osteoclastogenesis Osteoclasts Osteoclasts - drug effects Osteoclasts - metabolism Osteogenesis - drug effects p38 Mitogen-Activated Protein Kinases - metabolism Pmepa1 Prostate Protein Binding - drug effects RANK Ligand - metabolism RANK Ligand - pharmacology RANKL Rats, Sprague-Dawley RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Small Interfering - metabolism Rodents Signal transduction Signaling siRNA Stroma Subcellular Fractions - drug effects Subcellular Fractions - metabolism TRANCE protein Transforming Growth Factor beta - pharmacology Ubiquitin Ubiquitin-protein ligase
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