Platelet–leucocyte adhesion markers before and after the initiation of antiretroviral therapy with HIV protease inhibitors

Introduction Thromboembolic complications under antiretroviral therapy (ART) have been described in the past. In particular, the influence of protease inhibitors (PIs) on platelet activation and coagulation is currently under discussion. Methods HIV-1-infected, PI-naive adults (n = 18) were investig...

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 2008-11, Vol.62 (5), p.1118-1121
Hauptverfasser:	von Hentig, Nils, Förster, Ann-Kristin, Kuczka, Karina, Klinkhardt, Ute, Klauke, Stefan, Gute, Peter, Staszewski, Schlomo, Harder, Sebastian, Graff, Jochen
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antibiotics. Antiinfectious agents. Antiparasitic agents Antiretroviral drugs Biological and medical sciences Blood Platelets - chemistry Blood Platelets - drug effects CD11b Antigen - analysis CD40 Ligand - analysis CD40L CD41 Cell Adhesion Molecules - biosynthesis Drug therapy Female Flow Cytometry HIV HIV Infections - drug therapy HIV PIs HIV Protease Inhibitors - adverse effects HIV Protease Inhibitors - therapeutic use Human immunodeficiency virus Human viral diseases Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infectious diseases leucocytes Leukocytes Leukocytes - chemistry Leukocytes - drug effects Male Medical sciences Middle Aged Molecular biology P-Selectin - analysis Pharmacology. Drug treatments Platelet Membrane Glycoprotein IIb - analysis platelets Protease inhibitors Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids
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