$A prospective trial to evaluate the safety and efficacy of pravastatin for the treatment of refractory chronic graft-versus-host disease$

A prospective trial to evaluate the safety and efficacy of pravastatin for the treatment of refractory chronic graft-versus-host disease

This prospective study evaluates the safety and efficacy of pravastatin for the treatment of chronic graft-versus-host disease (GVHD). We included 18 patients with refractory chronic GVHD. Oral pravastatin was started at 10 mg/day, and the dose was increased up to 40 mg/day in 4 weeks. This maximum...

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Veröffentlicht in:	Transplantation 2005-02, Vol.79 (3), p.372-374
Hauptverfasser:	HORI, Akiko, KANDA, Yoshinobu, KOJIMA, Rie, HAMAKI, Tamae, SAKIYAMA, Michiyo, KAMI, Masahiro, MAKIMOTO, Atsushi, TANOSAKI, Ryuji, TAKAUE, Yoichi, HIRAI, Hisamaru, GOYAMA, Susumu, ONISHI, Yasushi, KOMENO, Yukiko, MITANI, Kinuko, KISHI, Yukiko, OGAWA, Seishi, IMATAKI, Osamu, CHIBA, Shigeru
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Chronic Disease Fundamental and applied biological sciences. Psychology Fundamental immunology Graft vs Host Disease - drug therapy Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Medical sciences Pravastatin - adverse effects Pravastatin - therapeutic use Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Th1 Cells - drug effects Th1 Cells - immunology Th2 Cells - drug effects Th2 Cells - immunology Tissue, organ and graft immunology
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