Hepatoprotective and cytotoxic activities of Anvillea garcinii and isolation of four new secondary metabolites
Anvillea garcinii is a medicinal plant traditionally used for the treatment of dysentery, gastrointestinal troubles, hepatitis, lung disease, colds, digestive problems and pulmonary affections and in liver diseases. Four new sesquiterpene lactones, garcinamines A–D, along with seven known compounds,...
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| Veröffentlicht in: | Journal of natural medicines 2018, Vol.72 (1), p.106-117 |
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| container_title | Journal of natural medicines |
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| creator | Perveen, Shagufta Al-Taweel, Areej Mohammad Yusufoglu, Hasan Soliman Fawzy, Ghada Ahmed Foudah, Ahmed Abdel-Kader, Maged Saad |
| description | Anvillea garcinii
is a medicinal plant traditionally used for the treatment of dysentery, gastrointestinal troubles, hepatitis, lung disease, colds, digestive problems and pulmonary affections and in liver diseases. Four new sesquiterpene lactones, garcinamines A–D, along with seven known compounds, were isolated from the leaves of
A. garcinii
. This is the first report of the isolation of amino acid analogues of parthenolide-type sesquiterpene lactones from the family Asteraceae. Total ethanol extract of leaves as well as the chloroform and
n
-butanol fractions were tested for their hepatoprotective effect using the carbon tetrachloride liver toxicity model. The chloroform fraction, at a dose of 400 mg/kg, demonstrated a significant hepatoprotective effect comparable to silymarin in all serum and tissue parameters. The cytotoxicity of all extracts and compounds were evaluated against five human cancer cell lines: MCF-7, HCT-116, HepG2, Hela and A-549. The results indicated that the chloroform and
n
-butanol fractions and compounds
3
,
4
,
7
and
8
displayed significant cytotoxic activity against these cell lines. |
| doi_str_mv | 10.1007/s11418-017-1118-1 |
| format | Article |
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is a medicinal plant traditionally used for the treatment of dysentery, gastrointestinal troubles, hepatitis, lung disease, colds, digestive problems and pulmonary affections and in liver diseases. Four new sesquiterpene lactones, garcinamines A–D, along with seven known compounds, were isolated from the leaves of
A. garcinii
. This is the first report of the isolation of amino acid analogues of parthenolide-type sesquiterpene lactones from the family Asteraceae. Total ethanol extract of leaves as well as the chloroform and
n
-butanol fractions were tested for their hepatoprotective effect using the carbon tetrachloride liver toxicity model. The chloroform fraction, at a dose of 400 mg/kg, demonstrated a significant hepatoprotective effect comparable to silymarin in all serum and tissue parameters. The cytotoxicity of all extracts and compounds were evaluated against five human cancer cell lines: MCF-7, HCT-116, HepG2, Hela and A-549. The results indicated that the chloroform and
n
-butanol fractions and compounds
3
,
4
,
7
and
8
displayed significant cytotoxic activity against these cell lines.</description><identifier>ISSN: 1340-3443</identifier><identifier>EISSN: 1861-0293</identifier><identifier>DOI: 10.1007/s11418-017-1118-1</identifier><identifier>PMID: 28795371</identifier><language>eng</language><publisher>Singapore: Springer Singapore</publisher><subject>Amino acids ; Biomedical and Life Sciences ; Biomedicine ; Complementary & Alternative Medicine ; Cytotoxicity ; Herbal medicine ; Humans ; Liver - drug effects ; Liver - pathology ; Medicinal Chemistry ; Metabolites ; Original Paper ; Pharmacology/Toxicology ; Pharmacy ; Phytochemicals ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; Plant Sciences ; Plants, Medicinal - chemistry</subject><ispartof>Journal of natural medicines, 2018, Vol.72 (1), p.106-117</ispartof><rights>The Japanese Society of Pharmacognosy and Springer Japan KK 2017</rights><rights>Copyright Springer Nature B.V. 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c399t-858ece6a137e46ca9cde652f83e0f29d8d6463fb24b80c0c384b15651ef7d3df3</citedby><cites>FETCH-LOGICAL-c399t-858ece6a137e46ca9cde652f83e0f29d8d6463fb24b80c0c384b15651ef7d3df3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11418-017-1118-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11418-017-1118-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27929,27930,41493,42562,51324</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28795371$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Perveen, Shagufta</creatorcontrib><creatorcontrib>Al-Taweel, Areej Mohammad</creatorcontrib><creatorcontrib>Yusufoglu, Hasan Soliman</creatorcontrib><creatorcontrib>Fawzy, Ghada Ahmed</creatorcontrib><creatorcontrib>Foudah, Ahmed</creatorcontrib><creatorcontrib>Abdel-Kader, Maged Saad</creatorcontrib><title>Hepatoprotective and cytotoxic activities of Anvillea garcinii and isolation of four new secondary metabolites</title><title>Journal of natural medicines</title><addtitle>J Nat Med</addtitle><addtitle>J Nat Med</addtitle><description>Anvillea garcinii
is a medicinal plant traditionally used for the treatment of dysentery, gastrointestinal troubles, hepatitis, lung disease, colds, digestive problems and pulmonary affections and in liver diseases. Four new sesquiterpene lactones, garcinamines A–D, along with seven known compounds, were isolated from the leaves of
A. garcinii
. This is the first report of the isolation of amino acid analogues of parthenolide-type sesquiterpene lactones from the family Asteraceae. Total ethanol extract of leaves as well as the chloroform and
n
-butanol fractions were tested for their hepatoprotective effect using the carbon tetrachloride liver toxicity model. The chloroform fraction, at a dose of 400 mg/kg, demonstrated a significant hepatoprotective effect comparable to silymarin in all serum and tissue parameters. The cytotoxicity of all extracts and compounds were evaluated against five human cancer cell lines: MCF-7, HCT-116, HepG2, Hela and A-549. The results indicated that the chloroform and
n
-butanol fractions and compounds
3
,
4
,
7
and
8
displayed significant cytotoxic activity against these cell lines.</description><subject>Amino acids</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Complementary & Alternative Medicine</subject><subject>Cytotoxicity</subject><subject>Herbal medicine</subject><subject>Humans</subject><subject>Liver - drug effects</subject><subject>Liver - pathology</subject><subject>Medicinal Chemistry</subject><subject>Metabolites</subject><subject>Original Paper</subject><subject>Pharmacology/Toxicology</subject><subject>Pharmacy</subject><subject>Phytochemicals</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Plant Sciences</subject><subject>Plants, Medicinal - chemistry</subject><issn>1340-3443</issn><issn>1861-0293</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1PHSEUhknTpn60P8CNIemmm7GcgeFjaUxbTUzc6JowzMFg5sLtwNX67-V6tTFNXHHCec4L73kJOQJ2AoypHwVAgO4YqA6gFfCB7IOW0LHe8I-t5oJ1XAi-Rw5KuWNM9JzDZ7LXa2UGrmCfpHNcu5rXS67oa7xH6tJE_WPNNf-NnrrtZawRC82Bnqb7OM_o6K1bfEwxPtOx5NnVmNMWCXmz0IQPtKDPaXLLI11hdWOeY8XyhXwKbi749eU8JDe_fl6fnXeXV78vzk4vO8-NqZ0eNHqUDrhCIb0zfkI59EFzZKE3k56kkDyMvRg188xzLUYY5AAY1MSnwA_J951uM_Zng6XaVSwe59klzJtiwfRKcym5aui3_9C7ZiG13zVKG66NAtEo2FF-yaUsGOx6iavmzgKz2zDsLgzbwrDbMCy0meMX5c24wunfxOv2G9DvgNJa6RaXN0-_q_oEioyWTQ</recordid><startdate>2018</startdate><enddate>2018</enddate><creator>Perveen, Shagufta</creator><creator>Al-Taweel, Areej Mohammad</creator><creator>Yusufoglu, Hasan Soliman</creator><creator>Fawzy, Ghada Ahmed</creator><creator>Foudah, Ahmed</creator><creator>Abdel-Kader, Maged Saad</creator><general>Springer Singapore</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>2018</creationdate><title>Hepatoprotective and cytotoxic activities of Anvillea garcinii and isolation of four new secondary metabolites</title><author>Perveen, Shagufta ; Al-Taweel, Areej Mohammad ; Yusufoglu, Hasan Soliman ; Fawzy, Ghada Ahmed ; Foudah, Ahmed ; Abdel-Kader, Maged Saad</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c399t-858ece6a137e46ca9cde652f83e0f29d8d6463fb24b80c0c384b15651ef7d3df3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Amino acids</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Complementary & Alternative Medicine</topic><topic>Cytotoxicity</topic><topic>Herbal medicine</topic><topic>Humans</topic><topic>Liver - drug effects</topic><topic>Liver - pathology</topic><topic>Medicinal Chemistry</topic><topic>Metabolites</topic><topic>Original Paper</topic><topic>Pharmacology/Toxicology</topic><topic>Pharmacy</topic><topic>Phytochemicals</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><topic>Plant Sciences</topic><topic>Plants, Medicinal - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Perveen, Shagufta</creatorcontrib><creatorcontrib>Al-Taweel, Areej Mohammad</creatorcontrib><creatorcontrib>Yusufoglu, Hasan Soliman</creatorcontrib><creatorcontrib>Fawzy, Ghada Ahmed</creatorcontrib><creatorcontrib>Foudah, Ahmed</creatorcontrib><creatorcontrib>Abdel-Kader, Maged Saad</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of natural medicines</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Perveen, Shagufta</au><au>Al-Taweel, Areej Mohammad</au><au>Yusufoglu, Hasan Soliman</au><au>Fawzy, Ghada Ahmed</au><au>Foudah, Ahmed</au><au>Abdel-Kader, Maged Saad</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hepatoprotective and cytotoxic activities of Anvillea garcinii and isolation of four new secondary metabolites</atitle><jtitle>Journal of natural medicines</jtitle><stitle>J Nat Med</stitle><addtitle>J Nat Med</addtitle><date>2018</date><risdate>2018</risdate><volume>72</volume><issue>1</issue><spage>106</spage><epage>117</epage><pages>106-117</pages><issn>1340-3443</issn><eissn>1861-0293</eissn><abstract>Anvillea garcinii
is a medicinal plant traditionally used for the treatment of dysentery, gastrointestinal troubles, hepatitis, lung disease, colds, digestive problems and pulmonary affections and in liver diseases. Four new sesquiterpene lactones, garcinamines A–D, along with seven known compounds, were isolated from the leaves of
A. garcinii
. This is the first report of the isolation of amino acid analogues of parthenolide-type sesquiterpene lactones from the family Asteraceae. Total ethanol extract of leaves as well as the chloroform and
n
-butanol fractions were tested for their hepatoprotective effect using the carbon tetrachloride liver toxicity model. The chloroform fraction, at a dose of 400 mg/kg, demonstrated a significant hepatoprotective effect comparable to silymarin in all serum and tissue parameters. The cytotoxicity of all extracts and compounds were evaluated against five human cancer cell lines: MCF-7, HCT-116, HepG2, Hela and A-549. The results indicated that the chloroform and
n
-butanol fractions and compounds
3
,
4
,
7
and
8
displayed significant cytotoxic activity against these cell lines.</abstract><cop>Singapore</cop><pub>Springer Singapore</pub><pmid>28795371</pmid><doi>10.1007/s11418-017-1118-1</doi><tpages>12</tpages></addata></record> |
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| ispartof | Journal of natural medicines, 2018, Vol.72 (1), p.106-117 |
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| language | eng |
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| source | MEDLINE; Springer Online Journals Complete |
| subjects | Amino acids Biomedical and Life Sciences Biomedicine Complementary & Alternative Medicine Cytotoxicity Herbal medicine Humans Liver - drug effects Liver - pathology Medicinal Chemistry Metabolites Original Paper Pharmacology/Toxicology Pharmacy Phytochemicals Plant Extracts - pharmacology Plant Extracts - therapeutic use Plant Sciences Plants, Medicinal - chemistry |
| title | Hepatoprotective and cytotoxic activities of Anvillea garcinii and isolation of four new secondary metabolites |
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