Nociceptin system does not affect MAC of volatile anaesthetics

Background: Nociceptin is the endogenous agonist of the opioid receptor‐like (ORL) 1 receptor (NOP), and both nociceptin and NOP are widely expressed in the brain and spinal cord, which are target organs of general anaesthetics. As nociceptin has been reported to be involved in modulating pain mech...

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Veröffentlicht in:	Acta anaesthesiologica Scandinavica 2005-07, Vol.49 (6), p.771-773
Hauptverfasser:	Himukashi, S., Miyazaki, Y., Takeshima, H., Koyanagi, S., Mukaida, K., Shichino, T., Uga, H., Fukuda, K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Anesthetics, Inhalation - pharmacokinetics Anesthetics, Inhalation - pharmacology Animals Biological and medical sciences Halothane - pharmacology Isoflurane - pharmacology Male Medical sciences Methyl Ethers - pharmacology Mice Mice, Inbred C57BL Mice, Knockout Minimum alveolar concentration Nociceptin Nociceptin Receptor nociceptin receptor knockout mice Opioid Peptides - physiology Pulmonary Alveoli - metabolism Receptors, Opioid - genetics Receptors, Opioid - physiology Sevoflurane volatile anaesthetics
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