NAAG peptidase inhibitor increases dialysate NAAG and reduces glutamate, aspartate and GABA levels in the dorsal hippocampus following fluid percussion injury in the rat

Traumatic brain injury (TBI) produces a rapid and excessive elevation in extracellular glutamate that induces excitotoxic brain cell death. The peptide neurotransmitter N‐acetylaspartylglutamate (NAAG) is reported to suppress neurotransmitter release through selective activation of presynaptic group...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of neurochemistry 2006-05, Vol.97 (4), p.1015-1025
Hauptverfasser:	Zhong, Chunlong, Zhao, Xueren, Van, Ken C., Bzdega, Tomasz, Smyth, Aoife, Zhou, Jia, Kozikowski, Alan P., Jiang, Jiyao, O'Connor, William T., Berman, Robert F., Neale, Joseph H., Lyeth, Bruce G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aspartic Acid - metabolism Biological and medical sciences Brain damage Brain Injuries - drug therapy Brain Injuries - metabolism Brain Injuries - physiopathology Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Cytoprotection - drug effects Cytoprotection - physiology Dipeptides - agonists Dipeptides - metabolism Disease Models, Animal Down-Regulation - drug effects Down-Regulation - physiology Enzyme Inhibitors - pharmacology Enzyme Inhibitors - therapeutic use Enzymes Extracellular Fluid - drug effects Extracellular Fluid - metabolism Fundamental and applied biological sciences. Psychology gamma-Aminobutyric Acid - metabolism gamma‐aminobutyric acid glutamate Glutamate Carboxypeptidase II - antagonists & inhibitors Glutamate Carboxypeptidase II - metabolism Glutamic Acid - metabolism Hippocampus - drug effects Hippocampus - metabolism Hippocampus - physiopathology Hypotheses Injuries of the nervous system and the skull. Diseases due to physical agents Male Medical sciences metabotropic glutamate receptor Microdialysis Nerve Degeneration - drug therapy Nerve Degeneration - physiopathology Nerve Degeneration - prevention & control Neurology Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Neurotoxins - antagonists & inhibitors Neurotoxins - metabolism Neurotransmitters N‐acetylaspartylglutamate Peptides Rats Rats, Sprague-Dawley Receptors, Glutamate - metabolism Rodents Trauma Traumas. Diseases due to physical agents traumatic brain injury Up-Regulation - drug effects Up-Regulation - physiology Vertebrates: nervous system and sense organs
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!