Thrombotic and cardiovascular risks in type two diabetes; Role of platelet hyperactivity
One of the most commonly identified chronic illnesses in many countries is type 2 diabetes mellitus (T2DM). T2DM denotes an independent risk factor for cardiovascular disease (CVD). Heart disease is one of the causes of mortality in patients with diabetes, mainly due to the macrovascular complicatio...
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| Veröffentlicht in: | Biomedicine & pharmacotherapy 2017-10, Vol.94, p.679-686 |
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| creator | Gaiz, Almottesembellah Mosawy, Sapha Colson, Natalie Singh, Indu |
| description | One of the most commonly identified chronic illnesses in many countries is type 2 diabetes mellitus (T2DM). T2DM denotes an independent risk factor for cardiovascular disease (CVD). Heart disease is one of the causes of mortality in patients with diabetes, mainly due to the macrovascular complications. One of these macrovascular complications in diabetes is atherosclerosis, which involves a complicated pathophysiological process. Besides hyperglycemia, oxidative stress plays a significant role in the pathogenesis of diabetes and its associated risk of CVD. There are many other factors including molecular, metabolic, lipid, fibrinolytic, and platelet function disorders precipitate to thrombotic and CVD risks in T2DM. Also, Platelets have an increased response to procoagulants in patients with diabetes. Platelet hyperactivity, in the presence of oxidative stress, has a major effect on the progression of thrombotic and CVD events. This review will discuss the impact of the above factors and the potential effects of platelet hyperactivity on thrombotic and cardiovascular risks. |
| doi_str_mv | 10.1016/j.biopha.2017.07.121 |
| format | Article |
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T2DM denotes an independent risk factor for cardiovascular disease (CVD). Heart disease is one of the causes of mortality in patients with diabetes, mainly due to the macrovascular complications. One of these macrovascular complications in diabetes is atherosclerosis, which involves a complicated pathophysiological process. Besides hyperglycemia, oxidative stress plays a significant role in the pathogenesis of diabetes and its associated risk of CVD. There are many other factors including molecular, metabolic, lipid, fibrinolytic, and platelet function disorders precipitate to thrombotic and CVD risks in T2DM. Also, Platelets have an increased response to procoagulants in patients with diabetes. Platelet hyperactivity, in the presence of oxidative stress, has a major effect on the progression of thrombotic and CVD events. This review will discuss the impact of the above factors and the potential effects of platelet hyperactivity on thrombotic and cardiovascular risks.</description><identifier>ISSN: 0753-3322</identifier><identifier>EISSN: 1950-6007</identifier><identifier>DOI: 10.1016/j.biopha.2017.07.121</identifier><identifier>PMID: 28787703</identifier><language>eng</language><publisher>France: Elsevier Masson SAS</publisher><subject>Animals ; Atherosclerosis - physiopathology ; Blood Platelets - metabolism ; Cardiovascular Diseases - etiology ; Cardiovascular Diseases - physiopathology ; CVD ; Diabetes ; Diabetes Mellitus, Type 2 - complications ; Humans ; Hyperactive platelets ; Hyperglycemia - physiopathology ; Oxidative stress ; Oxidative Stress - physiology ; Risk Factors ; Thrombosis ; Thrombosis - etiology ; Thrombosis - physiopathology</subject><ispartof>Biomedicine & pharmacotherapy, 2017-10, Vol.94, p.679-686</ispartof><rights>2017 Elsevier Masson SAS</rights><rights>Copyright © 2017 Elsevier Masson SAS. 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T2DM denotes an independent risk factor for cardiovascular disease (CVD). Heart disease is one of the causes of mortality in patients with diabetes, mainly due to the macrovascular complications. One of these macrovascular complications in diabetes is atherosclerosis, which involves a complicated pathophysiological process. Besides hyperglycemia, oxidative stress plays a significant role in the pathogenesis of diabetes and its associated risk of CVD. There are many other factors including molecular, metabolic, lipid, fibrinolytic, and platelet function disorders precipitate to thrombotic and CVD risks in T2DM. Also, Platelets have an increased response to procoagulants in patients with diabetes. Platelet hyperactivity, in the presence of oxidative stress, has a major effect on the progression of thrombotic and CVD events. This review will discuss the impact of the above factors and the potential effects of platelet hyperactivity on thrombotic and cardiovascular risks.</description><subject>Animals</subject><subject>Atherosclerosis - physiopathology</subject><subject>Blood Platelets - metabolism</subject><subject>Cardiovascular Diseases - etiology</subject><subject>Cardiovascular Diseases - physiopathology</subject><subject>CVD</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Humans</subject><subject>Hyperactive platelets</subject><subject>Hyperglycemia - physiopathology</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - physiology</subject><subject>Risk Factors</subject><subject>Thrombosis</subject><subject>Thrombosis - etiology</subject><subject>Thrombosis - physiopathology</subject><issn>0753-3322</issn><issn>1950-6007</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1r3DAURUVoSaZJ_kEJWmZj90myLZtAoQxJWggUSgrZCX08MZp6Rq6kmTD_Pg6TZtnV25x7L-8Q8plBzYB1X9a1CXFa6ZoDkzXImnF2QhZsaKHqAOQHsgDZikoIzs_Ip5zXANB2oj8lZ7yXvZQgFuTpcZXixsQSLNVbR61OLsS9znY36kRTyH8yDVtaDhPS8hypC9pgwXxDf8URafR0GnXBEQtdzUzStoR9KIcL8tHrMePl2z0nv-9uH5ffq4ef9z-W3x4q2_C-VN573hnfdr0WUniD2kJrGmzMMPhGtNw5NnjfA9dDpw04btu-m6Mtt-D6QZyT62PvlOLfHeaiNiFbHEe9xbjLig1cdsC55DPaHFGbYs4JvZpS2Oh0UAzUq1O1Vken6tWpAqlmp3Ps6m1hZzbo3kP_JM7A1yOA85_7gEllG3Br0YWEtigXw_8XXgBGG4sK</recordid><startdate>201710</startdate><enddate>201710</enddate><creator>Gaiz, Almottesembellah</creator><creator>Mosawy, Sapha</creator><creator>Colson, Natalie</creator><creator>Singh, Indu</creator><general>Elsevier Masson SAS</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201710</creationdate><title>Thrombotic and cardiovascular risks in type two diabetes; Role of platelet hyperactivity</title><author>Gaiz, Almottesembellah ; Mosawy, Sapha ; Colson, Natalie ; Singh, Indu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c428t-fff26bf568a373fbeac05b4e4b99f4352dd19ff802a96ab0d2c58642852c0d893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Atherosclerosis - physiopathology</topic><topic>Blood Platelets - metabolism</topic><topic>Cardiovascular Diseases - etiology</topic><topic>Cardiovascular Diseases - physiopathology</topic><topic>CVD</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Humans</topic><topic>Hyperactive platelets</topic><topic>Hyperglycemia - physiopathology</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - physiology</topic><topic>Risk Factors</topic><topic>Thrombosis</topic><topic>Thrombosis - etiology</topic><topic>Thrombosis - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gaiz, Almottesembellah</creatorcontrib><creatorcontrib>Mosawy, Sapha</creatorcontrib><creatorcontrib>Colson, Natalie</creatorcontrib><creatorcontrib>Singh, Indu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biomedicine & pharmacotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gaiz, Almottesembellah</au><au>Mosawy, Sapha</au><au>Colson, Natalie</au><au>Singh, Indu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Thrombotic and cardiovascular risks in type two diabetes; Role of platelet hyperactivity</atitle><jtitle>Biomedicine & pharmacotherapy</jtitle><addtitle>Biomed Pharmacother</addtitle><date>2017-10</date><risdate>2017</risdate><volume>94</volume><spage>679</spage><epage>686</epage><pages>679-686</pages><issn>0753-3322</issn><eissn>1950-6007</eissn><abstract>One of the most commonly identified chronic illnesses in many countries is type 2 diabetes mellitus (T2DM). 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| subjects | Animals Atherosclerosis - physiopathology Blood Platelets - metabolism Cardiovascular Diseases - etiology Cardiovascular Diseases - physiopathology CVD Diabetes Diabetes Mellitus, Type 2 - complications Humans Hyperactive platelets Hyperglycemia - physiopathology Oxidative stress Oxidative Stress - physiology Risk Factors Thrombosis Thrombosis - etiology Thrombosis - physiopathology |
| title | Thrombotic and cardiovascular risks in type two diabetes; Role of platelet hyperactivity |
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