Impacts of the serum containing total flavonoids of Ajuga on rat glomerular mesangial cells

The aim of the current study was to investigate the impacts and possible mechanisms of total flavonoids of Ajuga (TFA) on glomerular mesangial cells (GMC) through in vitro observations of the impacts of TFA‑containing serum on GMC proliferation and extracellular matrix (ECM) secretion in lipopolysac...

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Veröffentlicht in:	Molecular medicine reports 2017-10, Vol.16 (4), p.4895-4902
Hauptverfasser:	Nan, Lihong, Huang, Mei, Lai, Wenfang, Jia, Ru, Zheng, Yanfang, Yang, Lan, Xie, Qingqing, Peng, Weihua
Format:	Artikel
Sprache:	eng
Schlagworte:	Ajuga Ajuga - chemistry Animals Cell cycle Cell Cycle - drug effects Cell Line Cell Proliferation - drug effects Cell Survival - drug effects Cellular signal transduction Chinese medicine Collagen Collagen (type IV) Collagen Type IV - metabolism Disease Drug dosages Enzyme-linked immunosorbent assay Enzymes Ethanol Experiments Extracellular matrix Fibronectin Fibronectins - metabolism Flavonoids Flavonoids - pharmacokinetics Flavonoids - pharmacology Flow cytometry Free radicals G1 phase Gelatinase B Gene expression Gene Expression Regulation - drug effects Growth factors Health aspects Laboratory animals Lipid peroxidation Lipids Lipopolysaccharides Male Matrix metalloproteinase Matrix Metalloproteinase 9 - genetics Matrix Metalloproteinase 9 - metabolism Medical research Mesangial cells Mesangial Cells - drug effects Mesangial Cells - metabolism Metalloproteinase Polymerase chain reaction Rats Reverse transcription Rodents S phase Transforming growth factor Transforming Growth Factor beta1 - genetics Transforming Growth Factor beta1 - metabolism Transforming growth factor-b1
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