Strategies for preventing peritoneal fibrosis in peritoneal dialysis patients： new insights based on peritoneal inflammation and angiogenesis
Peritoneal dialysis (PD) is an established form of renal replacement therapy. Long-term PD leads to morphologic and functional changes to the peritoneal membrane (PM), which is defined as peritoneal fibrosis, a known cause of loss of peritoneal ultrafiltration capacity. Inflammation and angiogenesis...
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| Veröffentlicht in: | Frontiers of medicine 2017-09, Vol.11 (3), p.349-358 |
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| description | Peritoneal dialysis (PD) is an established form of renal replacement therapy. Long-term PD leads to morphologic and functional changes to the peritoneal membrane (PM), which is defined as peritoneal fibrosis, a known cause of loss of peritoneal ultrafiltration capacity. Inflammation and angiogenesis are key events during the pathogenesis of peritoneal fibrosis. This review discusses the pathophysiology of peritoneal fibrosis and recent research progress on key fibrogenic molecular mechanisms in peritoneal inflammation and angiogenesis, including Toll-like receptor ligand-mediated, NOD-like receptor protein 3/interleukin-1β, vascular endothelial growth factor, and angiopoietin-2/Tie2 signaling pathways. Furthermore, novel strategies targeting peritoneal inflammation and angiogenesis to preserve the PM are discussed in depth. |
| doi_str_mv | 10.1007/s11684-017-0571-2 |
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Long-term PD leads to morphologic and functional changes to the peritoneal membrane (PM), which is defined as peritoneal fibrosis, a known cause of loss of peritoneal ultrafiltration capacity. Inflammation and angiogenesis are key events during the pathogenesis of peritoneal fibrosis. This review discusses the pathophysiology of peritoneal fibrosis and recent research progress on key fibrogenic molecular mechanisms in peritoneal inflammation and angiogenesis, including Toll-like receptor ligand-mediated, NOD-like receptor protein 3/interleukin-1β, vascular endothelial growth factor, and angiopoietin-2/Tie2 signaling pathways. Furthermore, novel strategies targeting peritoneal inflammation and angiogenesis to preserve the PM are discussed in depth.</description><identifier>ISSN: 2095-0217</identifier><identifier>EISSN: 2095-0225</identifier><identifier>DOI: 10.1007/s11684-017-0571-2</identifier><identifier>PMID: 28791669</identifier><language>eng</language><publisher>Beijing: Higher Education Press</publisher><subject>Angiogenesis ; Humans ; Inflammation ; Medicine ; Medicine & Public Health ; Neovascularization, Pathologic - physiopathology ; Peritoneal dialysis ; Peritoneal Dialysis - adverse effects ; peritoneal fibrosis ; Peritoneal Fibrosis - etiology ; Peritoneal Fibrosis - physiopathology ; Peritoneal Fibrosis - prevention & control ; Peritonitis - etiology ; Peritonitis - metabolism ; Review ; Signal Transduction ; 患者 ; 炎症 ; 白细胞介素 ; 纤维化 ; 腹膜 ; 膜透析 ; 血管生成素 ; 预防策略</subject><ispartof>Frontiers of medicine, 2017-09, Vol.11 (3), p.349-358</ispartof><rights>Copyright reserved, 2017, Higher Education Press and Springer-Verlag Berlin Heidelberg</rights><rights>Higher Education Press and Springer-Verlag GmbH Germany 2017</rights><rights>Frontiers of Medicine is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c514t-99165ac7d67baccf430374be395adc4f2c2d71ad7938ac77904547d6de1609673</citedby><cites>FETCH-LOGICAL-c514t-99165ac7d67baccf430374be395adc4f2c2d71ad7938ac77904547d6de1609673</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/71235X/71235X.jpg</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11684-017-0571-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11684-017-0571-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27928,27929,41492,42561,51323</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28791669$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Zhen</creatorcontrib><creatorcontrib>Jiang, Na</creatorcontrib><creatorcontrib>Ni, Zhaohui</creatorcontrib><title>Strategies for preventing peritoneal fibrosis in peritoneal dialysis patients： new insights based on peritoneal inflammation and angiogenesis</title><title>Frontiers of medicine</title><addtitle>Front. Med</addtitle><addtitle>Frontiers of Medicine</addtitle><description>Peritoneal dialysis (PD) is an established form of renal replacement therapy. Long-term PD leads to morphologic and functional changes to the peritoneal membrane (PM), which is defined as peritoneal fibrosis, a known cause of loss of peritoneal ultrafiltration capacity. Inflammation and angiogenesis are key events during the pathogenesis of peritoneal fibrosis. This review discusses the pathophysiology of peritoneal fibrosis and recent research progress on key fibrogenic molecular mechanisms in peritoneal inflammation and angiogenesis, including Toll-like receptor ligand-mediated, NOD-like receptor protein 3/interleukin-1β, vascular endothelial growth factor, and angiopoietin-2/Tie2 signaling pathways. Furthermore, novel strategies targeting peritoneal inflammation and angiogenesis to preserve the PM are discussed in depth.</description><subject>Angiogenesis</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neovascularization, Pathologic - physiopathology</subject><subject>Peritoneal dialysis</subject><subject>Peritoneal Dialysis - adverse effects</subject><subject>peritoneal fibrosis</subject><subject>Peritoneal Fibrosis - etiology</subject><subject>Peritoneal Fibrosis - physiopathology</subject><subject>Peritoneal Fibrosis - prevention & control</subject><subject>Peritonitis - etiology</subject><subject>Peritonitis - metabolism</subject><subject>Review</subject><subject>Signal Transduction</subject><subject>患者</subject><subject>炎症</subject><subject>白细胞介素</subject><subject>纤维化</subject><subject>腹膜</subject><subject>膜透析</subject><subject>血管生成素</subject><subject>预防策略</subject><issn>2095-0217</issn><issn>2095-0225</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kUFu1TAQhi0EolXbA3SDIth0E2o7dhwvUUUBqRIL6Npy4kmeq8RO7TxQT8Ges3AnrsA85fFUWNSSZWv8_TPj-Qk5Z_Qto1RdZsbqRpSUqZJKxUr-jBxzqmVJOZfPD3emjshZzncUl6iZ0volOeKN0qyu9TH58WVJdoHBQy76mIo5wTcIiw9DMUPySwxgx6L3bYrZ58KHx2Hn7fiwC8928ajKv3_9LAJ8Ryz7YbPkorUZXBH_UfnQj3aaUIJxGxzuwccBAmCqU_Kit2OGs_15Qm6v33-9-ljefP7w6erdTdlJJpZSY_vSdsrVqrVd14uKVkq0UGlpXSd63nGnmHVKVw1iSlMhBdIOWE11raoTcrHmnVO830JezORzB-NoA8RtNkxzJbUUUiL65j_0Lm5TwO6QquSOrCuk2Ep1OKmcoDdz8pNND4ZRszPMrIYZNMzsDDMcNa_2mbftBO6g-GsPAnwFMj6FAdKj0k9kbVbRBj2ABA49zdn0KaKvkJ6Wvt5_YhPDcI8lDz3hzBhVjVLVH3gvwjY</recordid><startdate>20170901</startdate><enddate>20170901</enddate><creator>Zhang, Zhen</creator><creator>Jiang, Na</creator><creator>Ni, Zhaohui</creator><general>Higher Education Press</general><general>Springer Nature B.V</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20170901</creationdate><title>Strategies for preventing peritoneal fibrosis in peritoneal dialysis patients： new insights based on peritoneal inflammation and angiogenesis</title><author>Zhang, Zhen ; 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| subjects | Angiogenesis Humans Inflammation Medicine Medicine & Public Health Neovascularization, Pathologic - physiopathology Peritoneal dialysis Peritoneal Dialysis - adverse effects peritoneal fibrosis Peritoneal Fibrosis - etiology Peritoneal Fibrosis - physiopathology Peritoneal Fibrosis - prevention & control Peritonitis - etiology Peritonitis - metabolism Review Signal Transduction 患者 炎症 白细胞介素 纤维化 腹膜 膜透析 血管生成素 预防策略 |
| title | Strategies for preventing peritoneal fibrosis in peritoneal dialysis patients： new insights based on peritoneal inflammation and angiogenesis |
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