Patient-Reported Dyspnea Correlates Poorly with Aerobic Exercise Capacity Measured During Cardiopulmonary Exercise Testing

Background Patient-reported dyspnea plays a central role in assessing cardiopulmonary disease. There is little evidence, however, that dyspnea correlates with objective exercise capacity measurements. If the correlation is poor, dyspnea as a proxy for objective assessment may be misleading. Objectiv...

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Veröffentlicht in:Lung 2017-10, Vol.195 (5), p.613-617
Hauptverfasser: Gaspard, Dany, Kass, Jonathan, Akers, Stephen, Hunter, Krystal, Pratter, Melvin
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container_title Lung
container_volume 195
creator Gaspard, Dany
Kass, Jonathan
Akers, Stephen
Hunter, Krystal
Pratter, Melvin
description Background Patient-reported dyspnea plays a central role in assessing cardiopulmonary disease. There is little evidence, however, that dyspnea correlates with objective exercise capacity measurements. If the correlation is poor, dyspnea as a proxy for objective assessment may be misleading. Objective To compare patient’s perception of dyspnea with maximum oxygen uptake (MaxVO2) during cardiopulmonary exercise testing (CPET). Methods Fifty patients undergoing CPET for dyspnea evaluation were studied prospectively. Dyspnea assessment was measured by a metabolic equivalent of task (METs) table, Mahler Dyspnea Index, Borg Index, number of blocks walked, and flights of stairs climbed before stopping due to dyspnea. These descriptors were compared to MaxVO2. Results MaxVO2 showed low correlation with METs table ( r  = 0.388, p  = 0.005) and no correlation with Mahler Index ( r  = 0.24, p  = 0.093), Borg Index ( r  = −0.017, p  = 0.905), number of blocks walked ( r  = 0.266, p  = 0.077) or flights of stairs climbed ( r  = 0.188, p  = 0.217). When adjusted for weight (maxVO2/kg), there was significant correlation between MaxVO2 and METs table ( r  = 0.711, p  
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There is little evidence, however, that dyspnea correlates with objective exercise capacity measurements. If the correlation is poor, dyspnea as a proxy for objective assessment may be misleading. Objective To compare patient’s perception of dyspnea with maximum oxygen uptake (MaxVO2) during cardiopulmonary exercise testing (CPET). Methods Fifty patients undergoing CPET for dyspnea evaluation were studied prospectively. Dyspnea assessment was measured by a metabolic equivalent of task (METs) table, Mahler Dyspnea Index, Borg Index, number of blocks walked, and flights of stairs climbed before stopping due to dyspnea. These descriptors were compared to MaxVO2. Results MaxVO2 showed low correlation with METs table ( r  = 0.388, p  = 0.005) and no correlation with Mahler Index ( r  = 0.24, p  = 0.093), Borg Index ( r  = −0.017, p  = 0.905), number of blocks walked ( r  = 0.266, p  = 0.077) or flights of stairs climbed ( r  = 0.188, p  = 0.217). When adjusted for weight (maxVO2/kg), there was significant correlation between MaxVO2 and METs table ( r  = 0.711, p  &lt; 0.001), moderate correlation with blocks walked ( r  = 0.614, p  &lt; 0.001), and low correlation with Mahler Index ( r  = 0.488 p  = 0.001), Borg Index ( r  = −0.333 p  = 0.036), and flights of stairs ( r  = 0.457 p  = 0.004). Subgroup analysis showed worse correlation when patients with normal CPET were excluded (12/50 excluded). Patients with BMI &lt; 30 had no correlation between Max VO2 and the assessment methods, while patients with BMI &gt; 30 had moderate correlation between MaxVO2 and METs table ( r  = 0.568, p  = 0.002). Conclusion Patient-reported dyspnea correlates poorly with MaxVO2 and fails to predict exercise capacity. Reliance on reported dyspnea may result in suboptimal categorization of cardiopulmonary disease severity.</description><identifier>ISSN: 0341-2040</identifier><identifier>EISSN: 1432-1750</identifier><identifier>DOI: 10.1007/s00408-017-0043-0</identifier><identifier>PMID: 28791498</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adult ; Aerobic capacity ; Aged ; Aged, 80 and over ; Analysis ; Body mass ; Cardiopulmonary resuscitation ; Classification ; Correlation analysis ; CPR ; Dyspnea ; Dyspnea - physiopathology ; Exercise ; Exercise - physiology ; Exercise Test ; Exercise tests ; Exercise Tolerance - physiology ; Female ; Health aspects ; Humans ; Male ; Medicine ; Medicine &amp; Public Health ; Metabolic Equivalent ; Middle Aged ; Oxygen consumption ; Oxygen Consumption - physiology ; Oxygen uptake ; Patients ; Perception (Psychology) ; Pneumology/Respiratory System ; Prospective Studies ; Psychological aspects ; Respiration ; Self Report ; Tables ; Young Adult</subject><ispartof>Lung, 2017-10, Vol.195 (5), p.613-617</ispartof><rights>Springer Science+Business Media, LLC 2017</rights><rights>COPYRIGHT 2017 Springer</rights><rights>Lung is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c508t-f69b671d395535f7f899892df6e0dfdd568876a6f837dccff1fbb5a81ae2ec8a3</citedby><cites>FETCH-LOGICAL-c508t-f69b671d395535f7f899892df6e0dfdd568876a6f837dccff1fbb5a81ae2ec8a3</cites><orcidid>0000-0002-8991-2625 ; 0000-0002-7769-5440</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00408-017-0043-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00408-017-0043-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28791498$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gaspard, Dany</creatorcontrib><creatorcontrib>Kass, Jonathan</creatorcontrib><creatorcontrib>Akers, Stephen</creatorcontrib><creatorcontrib>Hunter, Krystal</creatorcontrib><creatorcontrib>Pratter, Melvin</creatorcontrib><title>Patient-Reported Dyspnea Correlates Poorly with Aerobic Exercise Capacity Measured During Cardiopulmonary Exercise Testing</title><title>Lung</title><addtitle>Lung</addtitle><addtitle>Lung</addtitle><description>Background Patient-reported dyspnea plays a central role in assessing cardiopulmonary disease. There is little evidence, however, that dyspnea correlates with objective exercise capacity measurements. If the correlation is poor, dyspnea as a proxy for objective assessment may be misleading. Objective To compare patient’s perception of dyspnea with maximum oxygen uptake (MaxVO2) during cardiopulmonary exercise testing (CPET). Methods Fifty patients undergoing CPET for dyspnea evaluation were studied prospectively. Dyspnea assessment was measured by a metabolic equivalent of task (METs) table, Mahler Dyspnea Index, Borg Index, number of blocks walked, and flights of stairs climbed before stopping due to dyspnea. These descriptors were compared to MaxVO2. Results MaxVO2 showed low correlation with METs table ( r  = 0.388, p  = 0.005) and no correlation with Mahler Index ( r  = 0.24, p  = 0.093), Borg Index ( r  = −0.017, p  = 0.905), number of blocks walked ( r  = 0.266, p  = 0.077) or flights of stairs climbed ( r  = 0.188, p  = 0.217). When adjusted for weight (maxVO2/kg), there was significant correlation between MaxVO2 and METs table ( r  = 0.711, p  &lt; 0.001), moderate correlation with blocks walked ( r  = 0.614, p  &lt; 0.001), and low correlation with Mahler Index ( r  = 0.488 p  = 0.001), Borg Index ( r  = −0.333 p  = 0.036), and flights of stairs ( r  = 0.457 p  = 0.004). Subgroup analysis showed worse correlation when patients with normal CPET were excluded (12/50 excluded). Patients with BMI &lt; 30 had no correlation between Max VO2 and the assessment methods, while patients with BMI &gt; 30 had moderate correlation between MaxVO2 and METs table ( r  = 0.568, p  = 0.002). Conclusion Patient-reported dyspnea correlates poorly with MaxVO2 and fails to predict exercise capacity. 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Kass, Jonathan ; Akers, Stephen ; Hunter, Krystal ; Pratter, Melvin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c508t-f69b671d395535f7f899892df6e0dfdd568876a6f837dccff1fbb5a81ae2ec8a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Aerobic capacity</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Analysis</topic><topic>Body mass</topic><topic>Cardiopulmonary resuscitation</topic><topic>Classification</topic><topic>Correlation analysis</topic><topic>CPR</topic><topic>Dyspnea</topic><topic>Dyspnea - physiopathology</topic><topic>Exercise</topic><topic>Exercise - physiology</topic><topic>Exercise Test</topic><topic>Exercise tests</topic><topic>Exercise Tolerance - physiology</topic><topic>Female</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine &amp; Public Health</topic><topic>Metabolic Equivalent</topic><topic>Middle Aged</topic><topic>Oxygen consumption</topic><topic>Oxygen Consumption - physiology</topic><topic>Oxygen uptake</topic><topic>Patients</topic><topic>Perception (Psychology)</topic><topic>Pneumology/Respiratory System</topic><topic>Prospective Studies</topic><topic>Psychological aspects</topic><topic>Respiration</topic><topic>Self Report</topic><topic>Tables</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gaspard, Dany</creatorcontrib><creatorcontrib>Kass, Jonathan</creatorcontrib><creatorcontrib>Akers, Stephen</creatorcontrib><creatorcontrib>Hunter, Krystal</creatorcontrib><creatorcontrib>Pratter, Melvin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing &amp; 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There is little evidence, however, that dyspnea correlates with objective exercise capacity measurements. If the correlation is poor, dyspnea as a proxy for objective assessment may be misleading. Objective To compare patient’s perception of dyspnea with maximum oxygen uptake (MaxVO2) during cardiopulmonary exercise testing (CPET). Methods Fifty patients undergoing CPET for dyspnea evaluation were studied prospectively. Dyspnea assessment was measured by a metabolic equivalent of task (METs) table, Mahler Dyspnea Index, Borg Index, number of blocks walked, and flights of stairs climbed before stopping due to dyspnea. These descriptors were compared to MaxVO2. Results MaxVO2 showed low correlation with METs table ( r  = 0.388, p  = 0.005) and no correlation with Mahler Index ( r  = 0.24, p  = 0.093), Borg Index ( r  = −0.017, p  = 0.905), number of blocks walked ( r  = 0.266, p  = 0.077) or flights of stairs climbed ( r  = 0.188, p  = 0.217). When adjusted for weight (maxVO2/kg), there was significant correlation between MaxVO2 and METs table ( r  = 0.711, p  &lt; 0.001), moderate correlation with blocks walked ( r  = 0.614, p  &lt; 0.001), and low correlation with Mahler Index ( r  = 0.488 p  = 0.001), Borg Index ( r  = −0.333 p  = 0.036), and flights of stairs ( r  = 0.457 p  = 0.004). Subgroup analysis showed worse correlation when patients with normal CPET were excluded (12/50 excluded). Patients with BMI &lt; 30 had no correlation between Max VO2 and the assessment methods, while patients with BMI &gt; 30 had moderate correlation between MaxVO2 and METs table ( r  = 0.568, p  = 0.002). Conclusion Patient-reported dyspnea correlates poorly with MaxVO2 and fails to predict exercise capacity. Reliance on reported dyspnea may result in suboptimal categorization of cardiopulmonary disease severity.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>28791498</pmid><doi>10.1007/s00408-017-0043-0</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-8991-2625</orcidid><orcidid>https://orcid.org/0000-0002-7769-5440</orcidid></addata></record>
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subjects Adult
Aerobic capacity
Aged
Aged, 80 and over
Analysis
Body mass
Cardiopulmonary resuscitation
Classification
Correlation analysis
CPR
Dyspnea
Dyspnea - physiopathology
Exercise
Exercise - physiology
Exercise Test
Exercise tests
Exercise Tolerance - physiology
Female
Health aspects
Humans
Male
Medicine
Medicine & Public Health
Metabolic Equivalent
Middle Aged
Oxygen consumption
Oxygen Consumption - physiology
Oxygen uptake
Patients
Perception (Psychology)
Pneumology/Respiratory System
Prospective Studies
Psychological aspects
Respiration
Self Report
Tables
Young Adult
title Patient-Reported Dyspnea Correlates Poorly with Aerobic Exercise Capacity Measured During Cardiopulmonary Exercise Testing
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