Estrogen receptor alpha and beta regulate actin polymerization and spatial memory through an SRC-1/mTORC2-dependent pathway in the hippocampus of female mice

[Display omitted] •Decreased mTORC2 signals are detected in the hippocampus of old mice.•Levels of hippocampal SRC-1and mTORC2 are regulated by E2 and ERs’ activity.•SRC-1 knockdown regulates mTORC2 and actin polymerization, mTORC2 knockdown regulates actin polymerization.•Activation of mTORC2 rescu...

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Veröffentlicht in:	The Journal of steroid biochemistry and molecular biology 2017-11, Vol.174, p.96-113
Hauptverfasser:	Zhao, Yangang, He, Li, Zhang, Yuanyuan, Zhao, Jikai, Liu, Zhi, Xing, Fangzhou, Liu, Mengying, Feng, Ziqi, Li, Wei, Zhang, Jiqiang
Format:	Artikel
Sprache:	eng
Schlagworte:	17β-Estradiol Actin Actin Depolymerizing Factors - metabolism Actin polymerization Actins - metabolism Alzheimer's disease Animals Aromatase Aromatase - metabolism Carrier Proteins - genetics Carrier Proteins - metabolism Cell Line Cofilin Dementia disorders Estradiol - pharmacology Estrogen receptor Estrogen Receptor alpha - metabolism Estrogen Receptor beta - metabolism Estrogen receptors Estrogens Estrogens - pharmacology Female Hippocampus Hippocampus - metabolism Mechanistic Target of Rapamycin Complex 2 Medical treatment Mice, Inbred C57BL Molecular modelling mTORC2 Multiprotein Complexes - metabolism Neurodegenerative diseases Nuclear Receptor Coactivator 1 - genetics Nuclear Receptor Coactivator 1 - metabolism Ovariectomy Polymerization Profilin Proto-Oncogene Proteins c-akt - metabolism Rapamycin-Insensitive Companion of mTOR Protein Rictor Rodents Spatial discrimination learning Spatial learning Spatial memory Spatial Memory - physiology Spine Steroid receptor coactivator 1 Studies TOR Serine-Threonine Kinases - metabolism
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