Amiloride, An Old Diuretic Drug, Is a Potential Therapeutic Agent for Multiple Myeloma

The search for new drugs that control the continuous relapses of multiple myeloma is still required. Here, we report for the first time the potent antimyeloma activity of amiloride, an old potassium-sparing diuretic approved for the treatment of hypertension and edema due to heart failure. Myeloma c...

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Veröffentlicht in:	Clinical cancer research 2017-11, Vol.23 (21), p.6602-6615
Hauptverfasser:	Rojas, Elizabeta A, Corchete, Luis Antonio, San-Segundo, Laura, Martínez-Blanch, Juan F, Codoñer, Francisco M, Paíno, Teresa, Puig, Noemí, García-Sanz, Ramón, Mateos, María Victoria, Ocio, Enrique M, Misiewicz-Krzeminska, Irena, Gutiérrez, Norma C
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative splicing Amiloride Amiloride - administration & dosage Amiloride - adverse effects Animals Apoptosis Apoptosis - drug effects Biocompatibility Biotechnology Cancer Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Chemical compounds Clonal deletion Cytotoxicity Deregulation Dexamethasone Diuretics Diuretics - administration & dosage Diuretics - adverse effects Drug Synergism Drugs Edema Experimental design Exposure Gene Expression Regulation, Neoplastic - drug effects Heart diseases Humans Hypertension Immunoblotting Immunofluorescence In vivo methods and tests Isoforms Machinery and equipment Melphalan Mice Multiple myeloma Multiple Myeloma - drug therapy Multiple Myeloma - genetics Multiple Myeloma - pathology Mutation p53 Protein Pharmacology Potassium Ribonucleic acid RNA Signal Transduction - drug effects Signaling Synergistic effect Toxicity Transcription Tumor cell lines Tumor Suppressor Protein p53 - genetics Xenograft Model Antitumor Assays Xenografts
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