Zika Virus Protease: An Antiviral Drug Target

The recent outbreak of Zika virus (ZIKV) infection has caused global concern due to its link to severe damage to the brain development of foetuses and neuronal complications in adult patients. A worldwide research effort has been undertaken to identify effective and safe treatment and vaccination op...

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Veröffentlicht in:	Trends in microbiology (Regular ed.) 2017-10, Vol.25 (10), p.797-808
Hauptverfasser:	Kang, CongBao, Keller, Thomas H., Luo, Dahai
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiviral Agents - pharmacology Antiviral Agents - therapeutic use Antiviral drugs Biochemistry Brain damage Brain injury Conformation Crystals Drug discovery Drug Discovery - methods Enzymatic activity Fetuses flavivirus Humans Life cycle engineering Life cycles Outbreaks Peptide Hydrolases - metabolism Peptide inhibitors Protease protease inhibitor Protein Conformation Proteinase Public health structure-based drug design Vaccination Vector-borne diseases Viral Proteins - metabolism Viruses Zika virus Zika Virus - drug effects Zika Virus - metabolism
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