Phenotypic and genetic heterogeneity within biofilms with particular emphasis on persistence and antimicrobial tolerance

Phenotypic changes or phase variation within biofilms is an important feature of bacterial dormant life. Enhanced resistance to antimicrobials is one of the distinct features displayed by a fraction of cells within biofilms. It is believed that persisters are mainly responsible for this phenotypic h...

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Veröffentlicht in:	Future microbiology 2017-09, Vol.12 (12), p.1087-1107
Hauptverfasser:	Sadiq, Faizan A, Flint, Steve, Li, YanJun, Ou, Kai, Yuan, Lei, He, Guo Qing
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology Antimicrobial agents antimicrobial tolerance Bacteria Bacteria - drug effects Bacteria - genetics Biofilms Biofilms - drug effects Biofilms - growth & development Deoxyribonucleic acid DNA Drug Resistance, Multiple, Bacterial Drug Tolerance - genetics E coli Gene expression Genetic Heterogeneity Genomes Genomics Heterogeneity Humans Mutagenesis Mutation persisters Phase variations Phenotype phenotypic heterogeneity Physiology Population Protein expression Proteins Proteomics Streptococcus infections Stress, Physiological
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