Mechanisms of foam cell formation in atherosclerosis

Low-density lipoprotein (LDL) and cholesterol homeostasis in the peripheral blood is maintained by specialized cells, such as macrophages. Macrophages express a variety of scavenger receptors (SR) that interact with lipoproteins, including SR-A1, CD36, and lectin-like oxLDL receptor-1 (LOX-1). These...

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Veröffentlicht in:	Journal of molecular medicine (Berlin, Germany) Germany), 2017-11, Vol.95 (11), p.1153-1165
Hauptverfasser:	Chistiakov, Dimitry A., Melnichenko, Alexandra A., Myasoedova, Veronika A., Grechko, Andrey V., Orekhov, Alexander N.
Format:	Artikel
Sprache:	eng
Schlagworte:	ABCA1 protein Acetyltransferase Animals Arteriosclerosis Atherosclerosis Atherosclerosis - etiology Atherosclerosis - pathology ATP-binding protein Biological Transport Biomedical and Life Sciences Biomedicine CD36 antigen Cholesterol Cholesterol - metabolism Endoplasmic reticulum Endosomes Endothelial Cells - metabolism Esterification Esters Foam Cells - immunology Foam Cells - metabolism Foam Cells - pathology Homeostasis Human Genetics Humans Hydrolase Inflammation Internal Medicine Lipase Lipid Metabolism Lipids Lipoproteins Lipoproteins, LDL - metabolism Liquid oxygen Low density lipoprotein LOX-1 protein Lysosomes Macrophages Macrophages - immunology Macrophages - metabolism Macrophages - pathology MicroRNAs - genetics Molecular Medicine Myocytes, Smooth Muscle - metabolism Peripheral blood Phagocytosis Review Scavenger receptors Smooth muscle
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