Biosynthesis and combinatorial biosynthesis of antifungal nucleoside antibiotics
There is an urgent need for new antifungal agents to treat or combat fungal infection in humans and plants.Antifungal nucleoside antibiotics are an important family of natural products with distinctive structural features.Understanding their biosynthetic machinery is of great importance for the impr...
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| Veröffentlicht in: | Science China. Life sciences 2017-09, Vol.60 (9), p.939-947 |
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| container_title | Science China. Life sciences |
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| creator | Niu, Guoqing Zheng, Jiazhen Tan, Huarong |
| description | There is an urgent need for new antifungal agents to treat or combat fungal infection in humans and plants.Antifungal nucleoside antibiotics are an important family of natural products with distinctive structural features.Understanding their biosynthetic machinery is of great importance for the improvement of antibiotics titers.More importantly,it is a requisite for combinatorial biosynthesis to create hybrid nucleoside antibiotics.We herein focus on findings on the natural and designed biosynthesis of this important family of nucleoside antibiotics. |
| doi_str_mv | 10.1007/s11427-017-9116-0 |
| format | Article |
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| subjects | Antibiotics Antifungal agents Antifungal Agents - chemistry Antifungal Agents - metabolism Biomedical and Life Sciences Biosynthesis Biosynthetic Pathways Life Sciences Metabolic Engineering Natural products Nucleosides - biosynthesis Nucleosides - chemistry Nucleosides - genetics Review 天然产品 家庭 抗真菌 核苷类抗生素 真菌感染 组合生物合成 结构特征 药物治疗 |
| title | Biosynthesis and combinatorial biosynthesis of antifungal nucleoside antibiotics |
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