Survival of melanoma patients treated with targeted therapy and immunotherapy after systematic upfront control of brain metastases by radiosurgery

Targeted therapy (TT) and immunotherapies (ITs) have dramatically improved survival in metastatic melanoma (MM). However, their efficacy on brain metastasis (BM) remains limited and poorly documented. Retrospective cohort of consecutive MM patients (pts) with BMs, all systematically upfront treated...

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Veröffentlicht in:	European journal of cancer (1990) 2017-10, Vol.84, p.44-54
Hauptverfasser:	Gaudy-Marqueste, C., Dussouil, A.S., Carron, R., Troin, L., Malissen, N., Loundou, A., Monestier, S., Mallet, S., Richard, M.A., Régis, J.M., Grob, J.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies - adverse effects Antibodies - therapeutic use Antineoplastic Agents - adverse effects Antineoplastic Agents - therapeutic use Brain Brain cancer Brain metastasis Brain Neoplasms - enzymology Brain Neoplasms - mortality Brain Neoplasms - secondary Brain Neoplasms - therapy Breast cancer Check-point inhibitors Chemotherapy, Adjuvant Elk Female Gamma-Knife radiosurgery Humans Immunotherapy Immunotherapy - adverse effects Immunotherapy - methods Inhibitors Kaplan-Meier Estimate Male MAP Kinase Kinase Kinases - antagonists & inhibitors MAP Kinase Kinase Kinases - metabolism MEK inhibitors Melanoma Melanoma - enzymology Melanoma - mortality Melanoma - secondary Melanoma - therapy Metastases Metastasis Middle Aged Molecular Targeted Therapy - adverse effects Molecular Targeted Therapy - methods Monoclonal antibodies Multivariate Analysis Mutation Patients PD-1 protein Programmed Cell Death 1 Receptor - antagonists & inhibitors Programmed Cell Death 1 Receptor - immunology Proportional Hazards Models Protein Kinase Inhibitors - adverse effects Protein Kinase Inhibitors - therapeutic use Proto-Oncogene Proteins B-raf - antagonists & inhibitors Proto-Oncogene Proteins B-raf - genetics Proto-Oncogene Proteins B-raf - metabolism Radiology Radiosurgery Radiosurgery - adverse effects Radiosurgery - methods Retrospective Studies Risk Factors Skin Neoplasms - enzymology Skin Neoplasms - mortality Skin Neoplasms - pathology Skin Neoplasms - therapy Surgery Survival Targeted therapies Therapy Time Factors Treatment Outcome
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