Preclinical Pharmacology and Pharmacokinetics of GW433908, a Water-Soluble Prodrug of the Human Immunodeficiency Virus Protease Inhibitor Amprenavir

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Veröffentlicht in:	Antimicrobial Agents and Chemotherapy 2004-03, Vol.48 (3), p.791-798
Hauptverfasser:	FURFINE, Eric S, BAKER, Christopher T, HALE, Michael R, REYNOLDS, David J, SALISBURY, Jo A, SEARLE, Andy D, STUDENBERG, Scott D, TODD, Dan, TUNG, Roger D, SPALTENSTEIN, Andrew
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral Agents Biological and medical sciences Biological Availability Biotransformation Caco-2 Cells Carbamates Dogs GW433908 HIV Protease Inhibitors HIV Protease Inhibitors - pharmacokinetics HIV Protease Inhibitors - pharmacology Human immunodeficiency virus Humans Hydrogen-Ion Concentration Intestinal Absorption Male Mass Spectrometry Medical sciences Organophosphates Organophosphates - pharmacokinetics Organophosphates - pharmacology Organophosphates - toxicity Pharmacology. Drug treatments Prodrugs Prodrugs - pharmacokinetics Prodrugs - pharmacology Prodrugs - toxicity Rats Rats, Wistar Sulfonamides Sulfonamides - pharmacokinetics Sulfonamides - pharmacology Sulfonamides - toxicity
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