Preclinical Pharmacology and Pharmacokinetics of GW433908, a Water-Soluble Prodrug of the Human Immunodeficiency Virus Protease Inhibitor Amprenavir
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| Veröffentlicht in: | Antimicrobial Agents and Chemotherapy 2004-03, Vol.48 (3), p.791-798 |
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| container_title | Antimicrobial Agents and Chemotherapy |
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| creator | FURFINE, Eric S BAKER, Christopher T HALE, Michael R REYNOLDS, David J SALISBURY, Jo A SEARLE, Andy D STUDENBERG, Scott D TODD, Dan TUNG, Roger D SPALTENSTEIN, Andrew |
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| doi_str_mv | 10.1128/aac.48.3.791-798.2004 |
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</description><identifier>ISSN: 0066-4804</identifier><identifier>EISSN: 1098-6596</identifier><identifier>DOI: 10.1128/aac.48.3.791-798.2004</identifier><identifier>PMID: 14982766</identifier><identifier>CODEN: AACHAX</identifier><language>eng</language><publisher>Washington, DC: American Society for Microbiology</publisher><subject>Animals ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antiviral Agents ; Biological and medical sciences ; Biological Availability ; Biotransformation ; Caco-2 Cells ; Carbamates ; Dogs ; GW433908 ; HIV Protease Inhibitors ; HIV Protease Inhibitors - pharmacokinetics ; HIV Protease Inhibitors - pharmacology ; Human immunodeficiency virus ; Humans ; Hydrogen-Ion Concentration ; Intestinal Absorption ; Male ; Mass Spectrometry ; Medical sciences ; Organophosphates ; Organophosphates - pharmacokinetics ; Organophosphates - pharmacology ; Organophosphates - toxicity ; Pharmacology. Drug treatments ; Prodrugs ; Prodrugs - pharmacokinetics ; Prodrugs - pharmacology ; Prodrugs - toxicity ; Rats ; Rats, Wistar ; Sulfonamides ; Sulfonamides - pharmacokinetics ; Sulfonamides - pharmacology ; Sulfonamides - toxicity</subject><ispartof>Antimicrobial Agents and Chemotherapy, 2004-03, Vol.48 (3), p.791-798</ispartof><rights>2005 INIST-CNRS</rights><rights>Copyright © 2004 American Society for Microbiology</rights><rights>Copyright © 2004, American Society for Microbiology 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a603t-3806d67640e756a61c9257b250ed9a51a392f817db8a672cac60a414cc0ad6d13</citedby><cites>FETCH-LOGICAL-a603t-3806d67640e756a61c9257b250ed9a51a392f817db8a672cac60a414cc0ad6d13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC353103/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC353103/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15524131$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14982766$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>FURFINE, Eric S</creatorcontrib><creatorcontrib>BAKER, Christopher T</creatorcontrib><creatorcontrib>HALE, Michael R</creatorcontrib><creatorcontrib>REYNOLDS, David J</creatorcontrib><creatorcontrib>SALISBURY, Jo A</creatorcontrib><creatorcontrib>SEARLE, Andy D</creatorcontrib><creatorcontrib>STUDENBERG, Scott D</creatorcontrib><creatorcontrib>TODD, Dan</creatorcontrib><creatorcontrib>TUNG, Roger D</creatorcontrib><creatorcontrib>SPALTENSTEIN, Andrew</creatorcontrib><title>Preclinical Pharmacology and Pharmacokinetics of GW433908, a Water-Soluble Prodrug of the Human Immunodeficiency Virus Protease Inhibitor Amprenavir</title><title>Antimicrobial Agents and Chemotherapy</title><addtitle>AAC</addtitle><addtitle>Antimicrob Agents Chemother</addtitle><description>Classifications
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</description><subject>Animals</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antiviral Agents</subject><subject>Biological and medical sciences</subject><subject>Biological Availability</subject><subject>Biotransformation</subject><subject>Caco-2 Cells</subject><subject>Carbamates</subject><subject>Dogs</subject><subject>GW433908</subject><subject>HIV Protease Inhibitors</subject><subject>HIV Protease Inhibitors - pharmacokinetics</subject><subject>HIV Protease Inhibitors - pharmacology</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Hydrogen-Ion Concentration</subject><subject>Intestinal Absorption</subject><subject>Male</subject><subject>Mass Spectrometry</subject><subject>Medical sciences</subject><subject>Organophosphates</subject><subject>Organophosphates - pharmacokinetics</subject><subject>Organophosphates - pharmacology</subject><subject>Organophosphates - toxicity</subject><subject>Pharmacology. 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Antiinfectious agents. Antiparasitic agents</topic><topic>Antiviral Agents</topic><topic>Biological and medical sciences</topic><topic>Biological Availability</topic><topic>Biotransformation</topic><topic>Caco-2 Cells</topic><topic>Carbamates</topic><topic>Dogs</topic><topic>GW433908</topic><topic>HIV Protease Inhibitors</topic><topic>HIV Protease Inhibitors - pharmacokinetics</topic><topic>HIV Protease Inhibitors - pharmacology</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Hydrogen-Ion Concentration</topic><topic>Intestinal Absorption</topic><topic>Male</topic><topic>Mass Spectrometry</topic><topic>Medical sciences</topic><topic>Organophosphates</topic><topic>Organophosphates - pharmacokinetics</topic><topic>Organophosphates - pharmacology</topic><topic>Organophosphates - toxicity</topic><topic>Pharmacology. 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</abstract><cop>Washington, DC</cop><pub>American Society for Microbiology</pub><pmid>14982766</pmid><doi>10.1128/aac.48.3.791-798.2004</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0066-4804 |
| ispartof | Antimicrobial Agents and Chemotherapy, 2004-03, Vol.48 (3), p.791-798 |
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| language | eng |
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| source | MEDLINE; EZB Free E-Journals; PubMed Central |
| subjects | Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral Agents Biological and medical sciences Biological Availability Biotransformation Caco-2 Cells Carbamates Dogs GW433908 HIV Protease Inhibitors HIV Protease Inhibitors - pharmacokinetics HIV Protease Inhibitors - pharmacology Human immunodeficiency virus Humans Hydrogen-Ion Concentration Intestinal Absorption Male Mass Spectrometry Medical sciences Organophosphates Organophosphates - pharmacokinetics Organophosphates - pharmacology Organophosphates - toxicity Pharmacology. Drug treatments Prodrugs Prodrugs - pharmacokinetics Prodrugs - pharmacology Prodrugs - toxicity Rats Rats, Wistar Sulfonamides Sulfonamides - pharmacokinetics Sulfonamides - pharmacology Sulfonamides - toxicity |
| title | Preclinical Pharmacology and Pharmacokinetics of GW433908, a Water-Soluble Prodrug of the Human Immunodeficiency Virus Protease Inhibitor Amprenavir |
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