Beyond a Carrier: Graphene Quantum Dots as a Probe for Programmatically Monitoring Anti-Cancer Drug Delivery, Release, and Response

Beyond a Carrier: Graphene Quantum Dots as a Probe for Programmatically Monitoring Anti-Cancer Drug Delivery, Release, and Response

On the basis of the unique physicochemical properties of graphene quantum dots (GQDs), we developed a novel type of theranostic agent by loading anticancer drug doxorubicin (DOX) to GQD’s surface and conjugating Cy5.5 (Cy) dye to GQD though a cathepsin D-responsive (P) peptide. Such type of agents d...

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Veröffentlicht in:ACS applied materials & interfaces 2017-08, Vol.9 (33), p.27396-27401
Hauptverfasser: Ding, Hui, Zhang, Fan, Zhao, Chaochao, Lv, Yanlin, Ma, Guanghui, Wei, Wei, Tian, Zhiyuan
Format: Artikel
Sprache:eng
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Antineoplastic Agents
Doxorubicin
Drug Delivery Systems
Graphite
Quantum Dots
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container_end_page 27401
container_issue 33
container_start_page 27396
container_title ACS applied materials & interfaces
container_volume 9
creator Ding, Hui
Zhang, Fan
Zhao, Chaochao
Lv, Yanlin
Ma, Guanghui
Wei, Wei
Tian, Zhiyuan
description On the basis of the unique physicochemical properties of graphene quantum dots (GQDs), we developed a novel type of theranostic agent by loading anticancer drug doxorubicin (DOX) to GQD’s surface and conjugating Cy5.5 (Cy) dye to GQD though a cathepsin D-responsive (P) peptide. Such type of agents demonstrated superior therapeutic performance both in vitro and in vivo because of the improved tissue penetration and cellular uptake. More importantly, they are capable of functioning as probes for programmed tracking the delivery and release of anticancer drug as well as drug-induced cancer cell apoptosis through GQD’s, DOX’s, and Cy’s charateristic fluorescence, respectively.
doi_str_mv 10.1021/acsami.7b08824
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source MEDLINE; ACS Publications
subjects Antineoplastic Agents
Doxorubicin
Drug Delivery Systems
Graphite
Quantum Dots
title Beyond a Carrier: Graphene Quantum Dots as a Probe for Programmatically Monitoring Anti-Cancer Drug Delivery, Release, and Response
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