Biotransformation of Chrysin to Baicalein: Selective C6-Hydroxylation of 5,7-Dihydroxyflavone Using Whole Yeast Cells Stably Expressing Human CYP1A1 Enzyme

Naturally occurring polyphenolic compounds are of medicinal importance because of their unique antioxidant, anticancer, and chemopreventive properties. Baicalein, a naturally occurring polyhydroxy flavonoid possessing a diverse range of pharmacological activities, has been used in traditional medici...

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Veröffentlicht in:	Journal of agricultural and food chemistry 2017-08, Vol.65 (34), p.7440-7446
Hauptverfasser:	Williams, Ibidapo S, Chib, Shifali, Nuthakki, Vijay K, Gatchie, Linda, Joshi, Prashant, Narkhede, Niteen A, Vishwakarma, Ram A, Bharate, Sandip B, Saran, Saurabh, Chaudhuri, Bhabatosh
Format:	Artikel
Sprache:	eng
Schlagworte:	Biocatalysis Biotransformation Cytochrome P-450 CYP1A1 - chemistry Cytochrome P-450 CYP1A1 - genetics Cytochrome P-450 CYP1A1 - isolation & purification Cytochrome P-450 CYP1A1 - metabolism Flavanones - metabolism Flavonoids - metabolism Gene Expression Humans Hydroxylation Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism
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