Serotonin Regulates Mammary Gland Development via an Autocrine-Paracrine Loop

Mammary gland development is controlled by a dynamic interplay between endocrine hormones and locally produced factors. Biogenic monoamines (serotonin, dopamine, norepinephrine, and others) are an important class of bioregulatory molecules that have not been shown to participate in mammary developme...

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Veröffentlicht in:	Developmental cell 2004-02, Vol.6 (2), p.193-203
Hauptverfasser:	Matsuda, Manabu, Imaoka, Tatsuhiko, Vomachka, Archie J, Gudelsky, Gary A, Hou, Zhaoyuan, Mistry, Meenakshi, Bailey, Jason P, Nieport, Kathryn M, Walther, Diego J, Bader, Michael, Horseman, Nelson D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn aromatic amine decarboxylase Aromatic-L-Amino-Acid Decarboxylases - genetics Aromatic-L-Amino-Acid Decarboxylases - metabolism Autocrine Communication - drug effects Autocrine Communication - physiology Caseins - genetics Caseins - metabolism Cells, Cultured Cloning, Molecular Dialysis Dose-Response Relationship, Drug Drug Interactions Epithelial Cells - drug effects Epithelial Cells - metabolism Female Fenclonine - pharmacology Gene Expression Regulation, Developmental Histology Humans Hydroxyindoleacetic Acid - metabolism Immunohistochemistry In Situ Hybridization Lactalbumin - genetics Lactalbumin - metabolism Mammary Glands, Human - cytology Mammary Glands, Human - drug effects Mammary Glands, Human - growth & development Methysergide - pharmacology Mice Mice, Inbred C57BL Mice, Knockout Milk - metabolism Milk Proteins - genetics Milk Proteins - metabolism Mucins - genetics Mucins - metabolism Organ Culture Techniques Paracrine Communication - drug effects Paracrine Communication - physiology Pregnancy Prolactin - deficiency Prolactin - genetics Prolactin - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - biosynthesis Serotonin - physiology Serotonin Antagonists - pharmacology Time Factors TPH1 gene tryptophan hydroxylase Tryptophan Hydroxylase - genetics Tryptophan Hydroxylase - metabolism
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