Drosophila CHIP protects against mitochondrial dysfunction by acting downstream of Pink1 in parallel with Parkin

ABSTRACT Mitochondrial kinase PTEN‐induced putative kinase 1 (PINK1) and E3 ubiquitin ligase Parkin function in a common pathway to regulate mitochondrial homeostasis contributing to the pathogenesis of Parkinson disease. The carboxyl terminus of Hsc70‐interacting protein (CHIP) acts as a heat shock...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The FASEB journal 2017-12, Vol.31 (12), p.5234-5245
Hauptverfasser:	Chen, Jia, Xue, Jin, Ruan, Jingsong, Zhao, Juan, Tang, Beisha, Duan, Ranhui
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Genetically Modified CRISPR Deactivation Defects Degeneration Deoxyribonucleic acid DNA DNA, Mitochondrial - genetics Dopamine receptors Drosophila Drosophila Proteins - genetics Drosophila Proteins - metabolism E3 ubiquitin ligase Flies Heat shock proteins Homeostasis Hsc70 protein Hsp70 protein Hsp90 protein Inactivation Indentation Insects Kinases Life span Locomotion Locomotion - genetics Locomotion - physiology Male Membrane Potential, Mitochondrial - genetics Membrane Potential, Mitochondrial - physiology Microscopy, Electron, Transmission Mitochondrial DNA Movement disorders Muscles Mutants Neurodegeneration Neurodegenerative diseases Nuclear Proteins - genetics Nuclear Proteins - metabolism Parkin protein Parkinson disease Parkinson's disease Pathogenesis Posture Protein folding Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism PTEN protein PTEN-induced putative kinase Thorax Ubiquitin Ubiquitin-protein ligase Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!