Determining the optimal vancomycin daily dose for pediatrics: a meta-analysis
Objective The objective of this study was to check which initial dose of vancomycin is needed to achieve the therapeutic target that is currently used in pediatrics. Methods The search was conducted in the following data sources: Pubmed (1980–2017), the Cochrane Library, and Embase (1986–2017) and t...
Gespeichert in:
| Veröffentlicht in: | European journal of clinical pharmacology 2017-11, Vol.73 (11), p.1341-1353 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1353 |
|---|---|
| container_issue | 11 |
| container_start_page | 1341 |
| container_title | European journal of clinical pharmacology |
| container_volume | 73 |
| creator | da Silva Alves, Geisa Cristina da Silva, Samuel Dutra Frade, Virginia Paula Rodrigues, Danielle Baldoni, André de Oliveira de Castro, Whocely Victor Sanches, Cristina |
| description | Objective
The objective of this study was to check which initial dose of vancomycin is needed to achieve the therapeutic target that is currently used in pediatrics.
Methods
The search was conducted in the following data sources: Pubmed (1980–2017), the Cochrane Library, and Embase (1986–2017) and the references of the published studies; searches were performed using the key terms: child, children, pediatrics, infants and adolescents, vancomycin, pharmacokinetics, and pharmacodynamics. The data extracted from the studies were analyzed and grouped using RevMan V 5.2 software. The confidence interval (CI) 95% and the odds ratio (OR) were calculated considering the Mantel-Haenszel random effect.
Results
From the 704 studies identified, 40 revealed eligibility for this review and only 20 presented enough data to be included in the statistical analysis. The articles found in this review were published between 1980 and 2017. The vancomycin doses varied between 40 mg/kg/day to 120 mg/kg/day. The statistical tests demonstrated significant clinical heterogeneity of I
2
(84%).
Conclusions
The meta-analysis study revealed in the majority of studies that doses lower than 60 mg/kg/day were not enough to achieve desirable vancomycin plasma concentrations “area under the curve in 24 h/minimum inhibitory concentration >400 (AUC
0-24
/MIC>400) or trough 10-20 mg/L” to control bacterial infections in pediatrics. |
| doi_str_mv | 10.1007/s00228-017-2306-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1926684902</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1957707357</sourcerecordid><originalsourceid>FETCH-LOGICAL-c438t-f9ef05aeba43218b964a07f97dce2d1aaf434cd8ae7b58c6a7e320da6e6de4753</originalsourceid><addsrcrecordid>eNp1kMtqHDEQRUWwicdOPiAbI_DGGyUlqVvq9s74GbDJJlmLGqnakenHROoxzN9Hw4yDMWRVizr3VnEY-yLhqwSw3zKAUo0AaYXSYIT-wBay0kpIqOQBWwBoKUxr4Ygd5_wMIOsW9Ed2pBprjWybBXu8ppnSEMc4PvH5N_FpNccBe_6Co5-GjY8jDxj7DQ9TJt5Nia8oRJxT9PmCIx9oRoEj9psc8yd22GGf6fN-nrBftzc_r-7Fw4-771eXD8JXuplF11IHNdISy7OyWbamQrBda4MnFSRiV-nKhwbJLuvGG7SkFQQ0ZAJVttYn7HzXu0rTnzXl2Q0xe-p7HGlaZydbZUxTtaAKevYOfZ7Wqfy7pWprweraFkruKJ-mnBN1bpWKhrRxEtzWtdu5dsW127p2umRO983r5UDhX-JVbgHUDshlNT5RenP6v61_AfPsibY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1957707357</pqid></control><display><type>article</type><title>Determining the optimal vancomycin daily dose for pediatrics: a meta-analysis</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>da Silva Alves, Geisa Cristina ; da Silva, Samuel Dutra ; Frade, Virginia Paula ; Rodrigues, Danielle ; Baldoni, André de Oliveira ; de Castro, Whocely Victor ; Sanches, Cristina</creator><creatorcontrib>da Silva Alves, Geisa Cristina ; da Silva, Samuel Dutra ; Frade, Virginia Paula ; Rodrigues, Danielle ; Baldoni, André de Oliveira ; de Castro, Whocely Victor ; Sanches, Cristina</creatorcontrib><description>Objective
The objective of this study was to check which initial dose of vancomycin is needed to achieve the therapeutic target that is currently used in pediatrics.
Methods
The search was conducted in the following data sources: Pubmed (1980–2017), the Cochrane Library, and Embase (1986–2017) and the references of the published studies; searches were performed using the key terms: child, children, pediatrics, infants and adolescents, vancomycin, pharmacokinetics, and pharmacodynamics. The data extracted from the studies were analyzed and grouped using RevMan V 5.2 software. The confidence interval (CI) 95% and the odds ratio (OR) were calculated considering the Mantel-Haenszel random effect.
Results
From the 704 studies identified, 40 revealed eligibility for this review and only 20 presented enough data to be included in the statistical analysis. The articles found in this review were published between 1980 and 2017. The vancomycin doses varied between 40 mg/kg/day to 120 mg/kg/day. The statistical tests demonstrated significant clinical heterogeneity of I
2
(84%).
Conclusions
The meta-analysis study revealed in the majority of studies that doses lower than 60 mg/kg/day were not enough to achieve desirable vancomycin plasma concentrations “area under the curve in 24 h/minimum inhibitory concentration >400 (AUC
0-24
/MIC>400) or trough 10-20 mg/L” to control bacterial infections in pediatrics.</description><identifier>ISSN: 0031-6970</identifier><identifier>EISSN: 1432-1041</identifier><identifier>DOI: 10.1007/s00228-017-2306-3</identifier><identifier>PMID: 28776198</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adolescents ; Anti-Bacterial Agents - administration & dosage ; Anti-Bacterial Agents - blood ; Anti-Bacterial Agents - pharmacokinetics ; Anti-Bacterial Agents - therapeutic use ; Antibiotics ; Bacteria ; Biomedical and Life Sciences ; Biomedicine ; Child ; Children ; Humans ; Infants ; Meta-analysis ; Minimum inhibitory concentration ; Pediatrics ; Pharmacodynamics ; Pharmacokinetics ; Pharmacology/Toxicology ; Review ; Statistical analysis ; Studies ; Vancomycin ; Vancomycin - administration & dosage ; Vancomycin - blood ; Vancomycin - pharmacokinetics ; Vancomycin - therapeutic use</subject><ispartof>European journal of clinical pharmacology, 2017-11, Vol.73 (11), p.1341-1353</ispartof><rights>Springer-Verlag GmbH Germany 2017</rights><rights>European Journal of Clinical Pharmacology is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-f9ef05aeba43218b964a07f97dce2d1aaf434cd8ae7b58c6a7e320da6e6de4753</citedby><cites>FETCH-LOGICAL-c438t-f9ef05aeba43218b964a07f97dce2d1aaf434cd8ae7b58c6a7e320da6e6de4753</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00228-017-2306-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00228-017-2306-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28776198$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>da Silva Alves, Geisa Cristina</creatorcontrib><creatorcontrib>da Silva, Samuel Dutra</creatorcontrib><creatorcontrib>Frade, Virginia Paula</creatorcontrib><creatorcontrib>Rodrigues, Danielle</creatorcontrib><creatorcontrib>Baldoni, André de Oliveira</creatorcontrib><creatorcontrib>de Castro, Whocely Victor</creatorcontrib><creatorcontrib>Sanches, Cristina</creatorcontrib><title>Determining the optimal vancomycin daily dose for pediatrics: a meta-analysis</title><title>European journal of clinical pharmacology</title><addtitle>Eur J Clin Pharmacol</addtitle><addtitle>Eur J Clin Pharmacol</addtitle><description>Objective
The objective of this study was to check which initial dose of vancomycin is needed to achieve the therapeutic target that is currently used in pediatrics.
Methods
The search was conducted in the following data sources: Pubmed (1980–2017), the Cochrane Library, and Embase (1986–2017) and the references of the published studies; searches were performed using the key terms: child, children, pediatrics, infants and adolescents, vancomycin, pharmacokinetics, and pharmacodynamics. The data extracted from the studies were analyzed and grouped using RevMan V 5.2 software. The confidence interval (CI) 95% and the odds ratio (OR) were calculated considering the Mantel-Haenszel random effect.
Results
From the 704 studies identified, 40 revealed eligibility for this review and only 20 presented enough data to be included in the statistical analysis. The articles found in this review were published between 1980 and 2017. The vancomycin doses varied between 40 mg/kg/day to 120 mg/kg/day. The statistical tests demonstrated significant clinical heterogeneity of I
2
(84%).
Conclusions
The meta-analysis study revealed in the majority of studies that doses lower than 60 mg/kg/day were not enough to achieve desirable vancomycin plasma concentrations “area under the curve in 24 h/minimum inhibitory concentration >400 (AUC
0-24
/MIC>400) or trough 10-20 mg/L” to control bacterial infections in pediatrics.</description><subject>Adolescents</subject><subject>Anti-Bacterial Agents - administration & dosage</subject><subject>Anti-Bacterial Agents - blood</subject><subject>Anti-Bacterial Agents - pharmacokinetics</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Antibiotics</subject><subject>Bacteria</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Child</subject><subject>Children</subject><subject>Humans</subject><subject>Infants</subject><subject>Meta-analysis</subject><subject>Minimum inhibitory concentration</subject><subject>Pediatrics</subject><subject>Pharmacodynamics</subject><subject>Pharmacokinetics</subject><subject>Pharmacology/Toxicology</subject><subject>Review</subject><subject>Statistical analysis</subject><subject>Studies</subject><subject>Vancomycin</subject><subject>Vancomycin - administration & dosage</subject><subject>Vancomycin - blood</subject><subject>Vancomycin - pharmacokinetics</subject><subject>Vancomycin - therapeutic use</subject><issn>0031-6970</issn><issn>1432-1041</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kMtqHDEQRUWwicdOPiAbI_DGGyUlqVvq9s74GbDJJlmLGqnakenHROoxzN9Hw4yDMWRVizr3VnEY-yLhqwSw3zKAUo0AaYXSYIT-wBay0kpIqOQBWwBoKUxr4Ygd5_wMIOsW9Ed2pBprjWybBXu8ppnSEMc4PvH5N_FpNccBe_6Co5-GjY8jDxj7DQ9TJt5Nia8oRJxT9PmCIx9oRoEj9psc8yd22GGf6fN-nrBftzc_r-7Fw4-771eXD8JXuplF11IHNdISy7OyWbamQrBda4MnFSRiV-nKhwbJLuvGG7SkFQQ0ZAJVttYn7HzXu0rTnzXl2Q0xe-p7HGlaZydbZUxTtaAKevYOfZ7Wqfy7pWprweraFkruKJ-mnBN1bpWKhrRxEtzWtdu5dsW127p2umRO983r5UDhX-JVbgHUDshlNT5RenP6v61_AfPsibY</recordid><startdate>20171101</startdate><enddate>20171101</enddate><creator>da Silva Alves, Geisa Cristina</creator><creator>da Silva, Samuel Dutra</creator><creator>Frade, Virginia Paula</creator><creator>Rodrigues, Danielle</creator><creator>Baldoni, André de Oliveira</creator><creator>de Castro, Whocely Victor</creator><creator>Sanches, Cristina</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20171101</creationdate><title>Determining the optimal vancomycin daily dose for pediatrics: a meta-analysis</title><author>da Silva Alves, Geisa Cristina ; da Silva, Samuel Dutra ; Frade, Virginia Paula ; Rodrigues, Danielle ; Baldoni, André de Oliveira ; de Castro, Whocely Victor ; Sanches, Cristina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-f9ef05aeba43218b964a07f97dce2d1aaf434cd8ae7b58c6a7e320da6e6de4753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adolescents</topic><topic>Anti-Bacterial Agents - administration & dosage</topic><topic>Anti-Bacterial Agents - blood</topic><topic>Anti-Bacterial Agents - pharmacokinetics</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Antibiotics</topic><topic>Bacteria</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Child</topic><topic>Children</topic><topic>Humans</topic><topic>Infants</topic><topic>Meta-analysis</topic><topic>Minimum inhibitory concentration</topic><topic>Pediatrics</topic><topic>Pharmacodynamics</topic><topic>Pharmacokinetics</topic><topic>Pharmacology/Toxicology</topic><topic>Review</topic><topic>Statistical analysis</topic><topic>Studies</topic><topic>Vancomycin</topic><topic>Vancomycin - administration & dosage</topic><topic>Vancomycin - blood</topic><topic>Vancomycin - pharmacokinetics</topic><topic>Vancomycin - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>da Silva Alves, Geisa Cristina</creatorcontrib><creatorcontrib>da Silva, Samuel Dutra</creatorcontrib><creatorcontrib>Frade, Virginia Paula</creatorcontrib><creatorcontrib>Rodrigues, Danielle</creatorcontrib><creatorcontrib>Baldoni, André de Oliveira</creatorcontrib><creatorcontrib>de Castro, Whocely Victor</creatorcontrib><creatorcontrib>Sanches, Cristina</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of clinical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>da Silva Alves, Geisa Cristina</au><au>da Silva, Samuel Dutra</au><au>Frade, Virginia Paula</au><au>Rodrigues, Danielle</au><au>Baldoni, André de Oliveira</au><au>de Castro, Whocely Victor</au><au>Sanches, Cristina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Determining the optimal vancomycin daily dose for pediatrics: a meta-analysis</atitle><jtitle>European journal of clinical pharmacology</jtitle><stitle>Eur J Clin Pharmacol</stitle><addtitle>Eur J Clin Pharmacol</addtitle><date>2017-11-01</date><risdate>2017</risdate><volume>73</volume><issue>11</issue><spage>1341</spage><epage>1353</epage><pages>1341-1353</pages><issn>0031-6970</issn><eissn>1432-1041</eissn><abstract>Objective
The objective of this study was to check which initial dose of vancomycin is needed to achieve the therapeutic target that is currently used in pediatrics.
Methods
The search was conducted in the following data sources: Pubmed (1980–2017), the Cochrane Library, and Embase (1986–2017) and the references of the published studies; searches were performed using the key terms: child, children, pediatrics, infants and adolescents, vancomycin, pharmacokinetics, and pharmacodynamics. The data extracted from the studies were analyzed and grouped using RevMan V 5.2 software. The confidence interval (CI) 95% and the odds ratio (OR) were calculated considering the Mantel-Haenszel random effect.
Results
From the 704 studies identified, 40 revealed eligibility for this review and only 20 presented enough data to be included in the statistical analysis. The articles found in this review were published between 1980 and 2017. The vancomycin doses varied between 40 mg/kg/day to 120 mg/kg/day. The statistical tests demonstrated significant clinical heterogeneity of I
2
(84%).
Conclusions
The meta-analysis study revealed in the majority of studies that doses lower than 60 mg/kg/day were not enough to achieve desirable vancomycin plasma concentrations “area under the curve in 24 h/minimum inhibitory concentration >400 (AUC
0-24
/MIC>400) or trough 10-20 mg/L” to control bacterial infections in pediatrics.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>28776198</pmid><doi>10.1007/s00228-017-2306-3</doi><tpages>13</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0031-6970 |
| ispartof | European journal of clinical pharmacology, 2017-11, Vol.73 (11), p.1341-1353 |
| issn | 0031-6970 1432-1041 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1926684902 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adolescents Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - blood Anti-Bacterial Agents - pharmacokinetics Anti-Bacterial Agents - therapeutic use Antibiotics Bacteria Biomedical and Life Sciences Biomedicine Child Children Humans Infants Meta-analysis Minimum inhibitory concentration Pediatrics Pharmacodynamics Pharmacokinetics Pharmacology/Toxicology Review Statistical analysis Studies Vancomycin Vancomycin - administration & dosage Vancomycin - blood Vancomycin - pharmacokinetics Vancomycin - therapeutic use |
| title | Determining the optimal vancomycin daily dose for pediatrics: a meta-analysis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-09T07%3A33%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Determining%20the%20optimal%20vancomycin%20daily%20dose%20for%20pediatrics:%20a%20meta-analysis&rft.jtitle=European%20journal%20of%20clinical%20pharmacology&rft.au=da%20Silva%20Alves,%20Geisa%20Cristina&rft.date=2017-11-01&rft.volume=73&rft.issue=11&rft.spage=1341&rft.epage=1353&rft.pages=1341-1353&rft.issn=0031-6970&rft.eissn=1432-1041&rft_id=info:doi/10.1007/s00228-017-2306-3&rft_dat=%3Cproquest_cross%3E1957707357%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1957707357&rft_id=info:pmid/28776198&rfr_iscdi=true |