Two flavone C-glycosides as quality control markers for the manufacturing process of ephedrine alkaloids-free Ephedra Herb extract (EFE) as a crude drug preparation
As part of our continuing study of ephedrine alkaloids-free Ephedra Herb extract (EFE) in pursuit of its approval as a crude drug preparation, we identified two quantitative markers for the quality control of the manufacturing process of EFE and sought to establish cost-effective and simple methods...
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| Veröffentlicht in: | Journal of natural medicines 2018, Vol.72 (1), p.73-79 |
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| creator | Oshima, Naohiro Maruyama, Takuro Yamashita, Tadatoshi Uchiyama, Nahoko Amakura, Yoshiaki Hyuga, Sumiko Hyuga, Masashi Nakamori, Shunsuke Takemoto, Hiroaki Kobayashi, Yoshinori Hakamatsuka, Takashi Odaguchi, Hiroshi Hanawa, Toshihiko Goda, Yukihiro |
| description | As part of our continuing study of ephedrine alkaloids-free Ephedra Herb extract (EFE) in pursuit of its approval as a crude drug preparation, we identified two quantitative markers for the quality control of the manufacturing process of EFE and sought to establish cost-effective and simple methods for quantitative analyses. We analysed Ephedra Herb extracts grown in different habitats and collection years by liquid chromatography/high-resolution mass spectrometry (LC/HRMS) and detected two notable peaks common to each extract. These peaks were identified as vicenin-2 (
1
) and isovitexin 2″-
O
-rhamnoside (
2
). Quantitative analyses using the isocratic condition of LC/MS showed that the content percentages of
1
and
2
in EFE were 0.140–0.146% and 0.350–0.411%, respectively. We concluded that
1
and
2
were adequate quality control markers for quantitative analysis of EFE. Furthermore, we quantitatively analysed apigenin (
3
), an aglycon common to
1
and
2
, and found that the conversion factors of
1
to
3
and
2
to
3
were 1.3 and 1.5, respectively. Therefore, we concluded that
3
was a secondary standard for quantifying the contents of
1
and
2
in EFE. A series of results obtained from this study will be valuable for the quality control of EFE. |
| doi_str_mv | 10.1007/s11418-017-1111-8 |
| format | Article |
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1
) and isovitexin 2″-
O
-rhamnoside (
2
). Quantitative analyses using the isocratic condition of LC/MS showed that the content percentages of
1
and
2
in EFE were 0.140–0.146% and 0.350–0.411%, respectively. We concluded that
1
and
2
were adequate quality control markers for quantitative analysis of EFE. Furthermore, we quantitatively analysed apigenin (
3
), an aglycon common to
1
and
2
, and found that the conversion factors of
1
to
3
and
2
to
3
were 1.3 and 1.5, respectively. Therefore, we concluded that
3
was a secondary standard for quantifying the contents of
1
and
2
in EFE. A series of results obtained from this study will be valuable for the quality control of EFE.</description><identifier>ISSN: 1340-3443</identifier><identifier>EISSN: 1861-0293</identifier><identifier>DOI: 10.1007/s11418-017-1111-8</identifier><identifier>PMID: 28776291</identifier><language>eng</language><publisher>Singapore: Springer Singapore</publisher><subject>Bans ; Biomedical and Life Sciences ; Biomedicine ; Complementary & Alternative Medicine ; Drug Compounding - methods ; Ephedra - chemistry ; Ephedrine - analysis ; Ephedrine - chemistry ; Flavones - chemistry ; Glycosides - metabolism ; Herbal medicine ; Medicinal Chemistry ; Original Paper ; Pharmacology/Toxicology ; Pharmacy ; Phytochemicals ; Plant Sciences ; Quality Control</subject><ispartof>Journal of natural medicines, 2018, Vol.72 (1), p.73-79</ispartof><rights>The Japanese Society of Pharmacognosy and Springer Japan KK 2017</rights><rights>Copyright Springer Nature B.V. 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c465t-b021303f342596ce201b835c23c6113e29021f674e3293c559399ed0498f5ab3</citedby><cites>FETCH-LOGICAL-c465t-b021303f342596ce201b835c23c6113e29021f674e3293c559399ed0498f5ab3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11418-017-1111-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11418-017-1111-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28776291$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oshima, Naohiro</creatorcontrib><creatorcontrib>Maruyama, Takuro</creatorcontrib><creatorcontrib>Yamashita, Tadatoshi</creatorcontrib><creatorcontrib>Uchiyama, Nahoko</creatorcontrib><creatorcontrib>Amakura, Yoshiaki</creatorcontrib><creatorcontrib>Hyuga, Sumiko</creatorcontrib><creatorcontrib>Hyuga, Masashi</creatorcontrib><creatorcontrib>Nakamori, Shunsuke</creatorcontrib><creatorcontrib>Takemoto, Hiroaki</creatorcontrib><creatorcontrib>Kobayashi, Yoshinori</creatorcontrib><creatorcontrib>Hakamatsuka, Takashi</creatorcontrib><creatorcontrib>Odaguchi, Hiroshi</creatorcontrib><creatorcontrib>Hanawa, Toshihiko</creatorcontrib><creatorcontrib>Goda, Yukihiro</creatorcontrib><title>Two flavone C-glycosides as quality control markers for the manufacturing process of ephedrine alkaloids-free Ephedra Herb extract (EFE) as a crude drug preparation</title><title>Journal of natural medicines</title><addtitle>J Nat Med</addtitle><addtitle>J Nat Med</addtitle><description>As part of our continuing study of ephedrine alkaloids-free Ephedra Herb extract (EFE) in pursuit of its approval as a crude drug preparation, we identified two quantitative markers for the quality control of the manufacturing process of EFE and sought to establish cost-effective and simple methods for quantitative analyses. We analysed Ephedra Herb extracts grown in different habitats and collection years by liquid chromatography/high-resolution mass spectrometry (LC/HRMS) and detected two notable peaks common to each extract. These peaks were identified as vicenin-2 (
1
) and isovitexin 2″-
O
-rhamnoside (
2
). Quantitative analyses using the isocratic condition of LC/MS showed that the content percentages of
1
and
2
in EFE were 0.140–0.146% and 0.350–0.411%, respectively. We concluded that
1
and
2
were adequate quality control markers for quantitative analysis of EFE. Furthermore, we quantitatively analysed apigenin (
3
), an aglycon common to
1
and
2
, and found that the conversion factors of
1
to
3
and
2
to
3
were 1.3 and 1.5, respectively. Therefore, we concluded that
3
was a secondary standard for quantifying the contents of
1
and
2
in EFE. A series of results obtained from this study will be valuable for the quality control of EFE.</description><subject>Bans</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Complementary & Alternative Medicine</subject><subject>Drug Compounding - methods</subject><subject>Ephedra - chemistry</subject><subject>Ephedrine - analysis</subject><subject>Ephedrine - chemistry</subject><subject>Flavones - chemistry</subject><subject>Glycosides - metabolism</subject><subject>Herbal medicine</subject><subject>Medicinal Chemistry</subject><subject>Original Paper</subject><subject>Pharmacology/Toxicology</subject><subject>Pharmacy</subject><subject>Phytochemicals</subject><subject>Plant Sciences</subject><subject>Quality Control</subject><issn>1340-3443</issn><issn>1861-0293</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1v1DAQhi0Eoh_wA7ggS1zKweCvJPYRrbYUqRKXvVuOM27TeuPUjoH9P_xQHLZUCAlf7LGfeWc8L0JvGP3AKO0-ZsYkU4SyjrC6iHqGTplqGaFci-f1LCQlQkpxgs5yvqNUciHYS3TCVde1XLNT9HP3PWIf7Lc4Ad6Qm3BwMY8DZGwzfig2jMsBuzgtKQa8t-keUsY-JrzcQo2n4q1bShqnGzyn6CBnHD2G-RaGegnYhnsb4jhk4hMA3v5-sPgKUo_hx5JqNr7YXm7fr_UsdqkMgIdUVjmYbbLLGKdX6IW3IcPrx_0c7S63u80Vuf76-cvm0zVxsm0W0lPOBBVeSN7o1gGnrFeicVy4ljEBXFfAt50EUefjmkYLrWGgUivf2F6co4ujbP3JQ4G8mP2YHYRgJ4glG6Z52yqpKa3ou3_Qu1jSVJurlNJC6dpDpdiRcinmnMCbOY11iAfDqFkdNEcHTXXQrA4aVXPePiqXfg_DU8YfyyrAj0Ce17FD-qv0f1V_AcNVpoM</recordid><startdate>2018</startdate><enddate>2018</enddate><creator>Oshima, Naohiro</creator><creator>Maruyama, Takuro</creator><creator>Yamashita, Tadatoshi</creator><creator>Uchiyama, Nahoko</creator><creator>Amakura, Yoshiaki</creator><creator>Hyuga, Sumiko</creator><creator>Hyuga, Masashi</creator><creator>Nakamori, Shunsuke</creator><creator>Takemoto, Hiroaki</creator><creator>Kobayashi, Yoshinori</creator><creator>Hakamatsuka, Takashi</creator><creator>Odaguchi, Hiroshi</creator><creator>Hanawa, Toshihiko</creator><creator>Goda, Yukihiro</creator><general>Springer Singapore</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>2018</creationdate><title>Two flavone C-glycosides as quality control markers for the manufacturing process of ephedrine alkaloids-free Ephedra Herb extract (EFE) as a crude drug preparation</title><author>Oshima, Naohiro ; Maruyama, Takuro ; Yamashita, Tadatoshi ; Uchiyama, Nahoko ; Amakura, Yoshiaki ; Hyuga, Sumiko ; Hyuga, Masashi ; Nakamori, Shunsuke ; Takemoto, Hiroaki ; Kobayashi, Yoshinori ; Hakamatsuka, Takashi ; Odaguchi, Hiroshi ; Hanawa, Toshihiko ; Goda, Yukihiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-b021303f342596ce201b835c23c6113e29021f674e3293c559399ed0498f5ab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Bans</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Complementary & Alternative Medicine</topic><topic>Drug Compounding - methods</topic><topic>Ephedra - chemistry</topic><topic>Ephedrine - analysis</topic><topic>Ephedrine - chemistry</topic><topic>Flavones - chemistry</topic><topic>Glycosides - metabolism</topic><topic>Herbal medicine</topic><topic>Medicinal Chemistry</topic><topic>Original Paper</topic><topic>Pharmacology/Toxicology</topic><topic>Pharmacy</topic><topic>Phytochemicals</topic><topic>Plant Sciences</topic><topic>Quality Control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oshima, Naohiro</creatorcontrib><creatorcontrib>Maruyama, Takuro</creatorcontrib><creatorcontrib>Yamashita, Tadatoshi</creatorcontrib><creatorcontrib>Uchiyama, Nahoko</creatorcontrib><creatorcontrib>Amakura, Yoshiaki</creatorcontrib><creatorcontrib>Hyuga, Sumiko</creatorcontrib><creatorcontrib>Hyuga, Masashi</creatorcontrib><creatorcontrib>Nakamori, Shunsuke</creatorcontrib><creatorcontrib>Takemoto, Hiroaki</creatorcontrib><creatorcontrib>Kobayashi, Yoshinori</creatorcontrib><creatorcontrib>Hakamatsuka, Takashi</creatorcontrib><creatorcontrib>Odaguchi, Hiroshi</creatorcontrib><creatorcontrib>Hanawa, Toshihiko</creatorcontrib><creatorcontrib>Goda, Yukihiro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of natural medicines</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oshima, Naohiro</au><au>Maruyama, Takuro</au><au>Yamashita, Tadatoshi</au><au>Uchiyama, Nahoko</au><au>Amakura, Yoshiaki</au><au>Hyuga, Sumiko</au><au>Hyuga, Masashi</au><au>Nakamori, Shunsuke</au><au>Takemoto, Hiroaki</au><au>Kobayashi, Yoshinori</au><au>Hakamatsuka, Takashi</au><au>Odaguchi, Hiroshi</au><au>Hanawa, Toshihiko</au><au>Goda, Yukihiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Two flavone C-glycosides as quality control markers for the manufacturing process of ephedrine alkaloids-free Ephedra Herb extract (EFE) as a crude drug preparation</atitle><jtitle>Journal of natural medicines</jtitle><stitle>J Nat Med</stitle><addtitle>J Nat Med</addtitle><date>2018</date><risdate>2018</risdate><volume>72</volume><issue>1</issue><spage>73</spage><epage>79</epage><pages>73-79</pages><issn>1340-3443</issn><eissn>1861-0293</eissn><abstract>As part of our continuing study of ephedrine alkaloids-free Ephedra Herb extract (EFE) in pursuit of its approval as a crude drug preparation, we identified two quantitative markers for the quality control of the manufacturing process of EFE and sought to establish cost-effective and simple methods for quantitative analyses. We analysed Ephedra Herb extracts grown in different habitats and collection years by liquid chromatography/high-resolution mass spectrometry (LC/HRMS) and detected two notable peaks common to each extract. These peaks were identified as vicenin-2 (
1
) and isovitexin 2″-
O
-rhamnoside (
2
). Quantitative analyses using the isocratic condition of LC/MS showed that the content percentages of
1
and
2
in EFE were 0.140–0.146% and 0.350–0.411%, respectively. We concluded that
1
and
2
were adequate quality control markers for quantitative analysis of EFE. Furthermore, we quantitatively analysed apigenin (
3
), an aglycon common to
1
and
2
, and found that the conversion factors of
1
to
3
and
2
to
3
were 1.3 and 1.5, respectively. Therefore, we concluded that
3
was a secondary standard for quantifying the contents of
1
and
2
in EFE. A series of results obtained from this study will be valuable for the quality control of EFE.</abstract><cop>Singapore</cop><pub>Springer Singapore</pub><pmid>28776291</pmid><doi>10.1007/s11418-017-1111-8</doi><tpages>7</tpages></addata></record> |
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| ispartof | Journal of natural medicines, 2018, Vol.72 (1), p.73-79 |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Bans Biomedical and Life Sciences Biomedicine Complementary & Alternative Medicine Drug Compounding - methods Ephedra - chemistry Ephedrine - analysis Ephedrine - chemistry Flavones - chemistry Glycosides - metabolism Herbal medicine Medicinal Chemistry Original Paper Pharmacology/Toxicology Pharmacy Phytochemicals Plant Sciences Quality Control |
| title | Two flavone C-glycosides as quality control markers for the manufacturing process of ephedrine alkaloids-free Ephedra Herb extract (EFE) as a crude drug preparation |
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