Structure of the complete elongation complex of RNA polymerase II with basal factors

In the early stage of transcription, eukaryotic RNA polymerase II (Pol II) exchanges initiation factors with elongation factors to form an elongation complex for processive transcription. Here we report the structure of the Pol II elongation complex bound with the basal elongation factors Spt4/5, El...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2017-09, Vol.357 (6354), p.921-924
Hauptverfasser:	Ehara, Haruhiko, Yokoyama, Takeshi, Shigematsu, Hideki, Yokoyama, Shigeyuki, Shirouzu, Mikako, Sekine, Shun-ichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Proteins - chemistry Bacterial Proteins - ultrastructure Cryoelectron Microscopy Crystallography Crystallography, X-Ray Deoxyribonucleic acid DNA DNA-directed RNA polymerase Electron microscopy Elongated structure Gene regulation Initiation factors Klebsiella - enzymology Protein Domains Rewinding Ribonucleic acid RNA RNA polymerase RNA polymerase II RNA Polymerase II - chemistry RNA Polymerase II - ultrastructure RNA, Messenger - biosynthesis Transcription elongation Transcription Elongation, Genetic Transcription factors Transcription Factors - chemistry Transcription Factors - ultrastructure Tunnels Unwinding X-ray crystallography
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