JCAD Promotes Progression of Nonalcoholic Steatohepatitis to Liver Cancer by Inhibiting LATS2 Kinase Activity

Nonalcoholic steatohepatitis-associated hepatocellular carcinoma (NASH-HCC) is a malignancy whose incidents are rapidly increasing. However, the mechanisms that drive development of HCC in a steatotic microenvironment remain unknown. Here we report that the obesity-associated protein JCAD is express...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2017-10, Vol.77 (19), p.5287-5300
Hauptverfasser:	Ye, Juan, Li, Tian-Sheng, Xu, Gang, Zhao, Yi-Ming, Zhang, Ning-Ping, Fan, Jia, Wu, Jian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Cell Adhesion Molecules - genetics Cell Adhesion Molecules - metabolism Cell Proliferation Disease Progression Fatty liver Gene Expression Regulation, Neoplastic Hepatocellular carcinoma Hepatoma Humans Kinases Lesions Liver Liver cancer Liver Neoplasms - genetics Liver Neoplasms - metabolism Liver Neoplasms - pathology Male Malignancy Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Nude Non-alcoholic Fatty Liver Disease - genetics Non-alcoholic Fatty Liver Disease - metabolism Non-alcoholic Fatty Liver Disease - pathology Obesity Phosphorylation Precancerous Conditions - genetics Precancerous Conditions - metabolism Precancerous Conditions - pathology Prognosis Protein-Serine-Threonine Kinases - antagonists & inhibitors Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism RNA, Small Interfering - genetics Signal Transduction Tumor Cells, Cultured Tumor suppressor genes Tumor Suppressor Proteins - antagonists & inhibitors Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism Xenograft Model Antitumor Assays Yes-associated protein
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