Design, synthesis and biological evaluation of some novel benzothiazole/benzoxazole and/or benzimidazole derivatives incorporating a pyrazole scaffold as antiproliferative agents

[Display omitted] •A series of substituted pyrazoles10a-c, 11a-c and 12a- was designed and prepared.•All the candidates benzimidazolo/benzoxazolo/benzothiazolo-pyrazolone hybrids were evaluated in vitro for their antiproliferative activity.•Compound 12a was the most active compound against both MCF-...

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Veröffentlicht in:	Bioorganic chemistry 2017-10, Vol.74, p.82-90
Hauptverfasser:	Abdelgawad, Mohamed A., Bakr, Rania B., Omar, Hany A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antiproliferative Benzimidazoles - chemistry Benzimidazoles - pharmacology Benzothiazole Benzothiazoles - chemistry Benzothiazoles - pharmacology Benzoxazole Benzoxazoles - chemistry Benzoxazoles - pharmacology Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects COX-2 inhibition Cyclooxygenase 1 - metabolism Cyclooxygenase 2 - metabolism Cyclooxygenase Inhibitors - chemical synthesis Cyclooxygenase Inhibitors - chemistry Cyclooxygenase Inhibitors - pharmacology Dose-Response Relationship, Drug Drug Design Drug Screening Assays, Antitumor Humans Models, Molecular Molecular Structure Pyrazole Pyrazoles - chemistry Pyrazoles - pharmacology Structure-Activity Relationship
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