Inhibition of FKBP10 Attenuates Hypertrophic Scarring through Suppressing Fibroblast Activity and Extracellular Matrix Deposition

Hypertrophic scar is a pathogenic form of scar formation with no recognized treatment to date. Its molecular mechanism is related to the abnormal proliferation and transition of fibroblasts and overproduction of extracellular matrix. FKBP10 is a molecular chaperone able to regulate α-smooth muscle a...

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Veröffentlicht in:	Journal of investigative dermatology 2017-11, Vol.137 (11), p.2326-2335
Hauptverfasser:	Liang, Xiao, Chai, Bangda, Duan, Ran, Zhou, Yiwen, Huang, Xiaolu, Li, Qingfeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biopsy, Needle Bleomycin - pharmacology Cells, Cultured Cicatrix, Hypertrophic - genetics Cicatrix, Hypertrophic - pathology Disease Models, Animal Extracellular Matrix - metabolism Fibroblasts - metabolism Fibroblasts - pathology Gene Expression Regulation Humans Immunohistochemistry Mice Random Allocation Real-Time Polymerase Chain Reaction RNA, Small Interfering - analysis Sensitivity and Specificity Signal Transduction Tacrolimus Binding Proteins - genetics Up-Regulation Wound Healing - drug effects Wound Healing - genetics
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